IODIPAMIDE Property

Melting point:

306-308°C (dec.)

Boiling point:

908.6±65.0 °C(Predicted)

Density 

2.5848 (estimate)

refractive index 

nD21.5 1.3294 (c = 0.445 in methanol)

storage temp. 

Room Temperature

solubility 

DMSO (Slightly), Methanol (Very Slightly)

pka

pKa 3.5(H2O) (Uncertain)

color 

White

Water Solubility 

0.46g/L(20 ºC)

Merck 

5022

EPA Substance Registry System

Benzoic acid, 3,3'-[(1,6-dioxo-1,6-hexanediyl)diimino]bis[2,4,6-triiodo- (606-17-7)

Safety

WGK Germany 

3

RTECS 

DG0949500

HS Code 

2924296000

Hazardous Substances Data

606-17-7(Hazardous Substances Data)

Toxicity

LD50 in mice, rats (mg/kg): 2380 ±290, 4430 ±310 i.v. (Rosenberg)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

IODIPAMIDE Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Cholografin,Squibb,US,1954

Uses

Diagnostic aid (radiopaque medium-cholecystographic).

Uses

antihypertensive, diuretic, activates K channels and AMPA receptors

Definition

ChEBI: Adipiodone is an organoiodine compound that is 3-amino-2,4,6-triiodobenzoic acid in which one of the amino hydrogens is substituted by a 6-(3-carboxy-2,4,6-triiodoanilino)-6-oxohexanoyl group. It is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography. It has a role as a radioopaque medium. It is an organoiodine compound, a member of benzoic acids and a secondary carboxamide. It is a conjugate acid of an adipiodone(2-).

Manufacturing Process

125 g of 2,4,6-triiodo-3-amino benzoic acid are dissolved in 250 cc of chlorobenzene and 15 g of adipic acid dichloride are added at a temperature between 110° and 130°C drop by drop to the solution. After evolution of hydrochloric acid (about 2 to 3 hours) has ceased, the precipitated crude adipic acid di-(3-carboxy-2,4,6-triiodo anilide) of the above formula is filtered hot with suction, washed with chlorobenzene, extracted by boiling with methanol and, for purification, dissolved in an amount of methanolic caustic soda solution required for neutralization, filtered with charcoal, and precipitated with dilute hydrochloric acid. Yield: 82.3 g, MP 306° to 308°C (with decomposition).

brand name

Pharmaceutic necessity for Iodipamide Meglumine [Injection]. Cholografin (Bristol-Myers Squibb).

Therapeutic Function

Diagnostic aid (radiopaque medium)

Hazard

Toxic by ingestion.