ChemicalBook > CAS DataBase List > brusatol

brusatol

Product Name: brusatol
CAS No.: 14907-98-3
Chemical Name: brusatol
Synonyms: 100935;Brusato1;Brustaol;Yatansin;NSC 172924;(+)-Brusatol;Brusatol - Bio-X ?;Brusatol >=95% (HPLC);Brusatol (NSC 172924);Brusatol, 10 mM in DMSO
CBNumber: CB31342731
Molecular Formula: C26H32O11
Formula Weight: 520.53
MOL File: 14907-98-3.mol

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brusatol Property

Boiling point:: 724.3±60.0 °C(Predicted)
Density: 1.46±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: -20°C
solubility: DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
pka: 8.81±0.70(Predicted)
form: powder
color: white to beige
biological source: (Brucia javanica)
optical activity: [α]/D +35 to +44°, c = 0.5 in acetone
InChIKey: ZZZYHIMVKOHVIH-YHSWLYNENA-N
LogP: 0.393 (est)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1868
Product name: Brusatol
Purity: ≥95% (HPLC)
Packaging: 5MG
Price: $113
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1868
Product name: Brusatol
Purity: ≥95% (HPLC)
Packaging: 25MG
Price: $435.1
Updated: 2025/07/31

TRC

Product number: B701056
Product name: (+)-Brusatol
Packaging: 5mg
Price: $315
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB30016
Product name: Brusatol
Packaging: 5mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-W019658
Product name: Brusatol
Purity: 99.89%
Packaging: 10mg
Price: $280
Updated: 2021/12/16

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brusatol Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Brucea javanica.

Uses

Brusatol has been used to study the protective role of Nrf2 (nuclear factor, erythroid 2 like 2 ) in intestinal ischemia/reperfusion induced injury.

Definition

ChEBI: Brusatol is a triterpenoid.

Biochem/physiol Actions

Brusatol promotes Nrf2 (nuclear factor, erythroid 2 like 2 ) ubiquitination and degradation. Brusatol upregulates the expression of multiple ribosomal components and controls macromolecular complex function.

in vivo

Brusatol is able to reach the tumor tissue and inhibit the Nrf2 pathway. Nude mice are injected with A549 cells to induce tumor growth, followed by a single i.p. injection of 2 mg/kg Brusatol. Nrf2 protein levels are significantly decreased at 24 h or 48 h postinjection^[1].
Cisplatin (2 mg/kg) or Brusatol (2 mg/kg) alone does not inhibit tumor growth significantly, whereas in the combination group, tumor size is significantly reduced^[1]. "

Animal Model:	Athymic nude mice 4-6 wk old bearing A549 xenografts^[1]
Dosage:	2 mg/kg
Administration:	Treated i.p.; Cisplatin (2 mg/kg), Brusatol (2 mg/kg), or in combination every other day for a total of five times
Result:	Nrf2 protein levels were significantly decreased at 24 h or 48 h postinjection. Cisplatin or Brusatol alone did not inhibit tumor growth significantly, whereas in the combination group, tumor size was significantly reduced.?"

brusatol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from brusatol manufacturers

Henan Fengda Chemical Co., Ltd

Product: brusatol 14907-98-3
Price: US $8.00-0.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Career Henan Chemical Co

Product: brusatol 14907-98-3
Price: US $1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-24

14907-98-3, brusatolRelated Search:

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13,20-Epoxy-3,11β,12α-trihydroxy-15β-[(3-methyl-1-oxo-2-butenyl)oxy]-2,16-dioxopicrasa-3-ene-21-oic acid methyl ester

methyl (1R,2S,3S,3aS,3a1R,4R,6aR,7aR,11aS,11bR)-1,2,9-trihydroxy-8,11a-dimethyl-4-((3-methylbut-2-enoyl)oxy)-5,10-dioxo-1,4,5,6a,7,7a,10,11,11a,11b-decahydro-2H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-3(3aH)-carboxylate

Picras-3-en-21-oicacid,13,20-epoxy-3,11,12-trihydroxy-15-[(3-Methyl-1-oxo-2-buten-1-yl)oxy]-2,16-dioxo-,Methyl ester, (11b,12a,15b)-

NSC 172924

Yatansin

Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-buten-1-yl)oxy]-

Brustaol

100935

Brusato1

Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-buten-1-yl)oxy]-2,16-dioxo-, methyl ester, (11β,12α,15β)-

Brusatol >=95% (HPLC)

(+)-Brusatol

(1R,2S,3S,3aS,3a1R,4R,6aR,7aR,11aS,11bR)-Methyl 1,2,9-trihydroxy-8,11a-dimethyl-4-((3-methylbut-2-enoyl)oxy)-5,10-dioxo-2,3,3a,4,5,6a,7,7a,10,11,11a,11b-dodecahydro-1H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-3-carboxylate

Brusatol (NSC 172924)

Brusatol, 10 mM in DMSO

Brusatol - Bio-X ?

14907-98-3