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brusatol

Product Name
brusatol
CAS No.
14907-98-3
Chemical Name
brusatol
Synonyms
100935;Brusato1;Brustaol;Yatansin;NSC 172924;(+)-Brusatol;Brusatol - Bio-X ?;Brusatol >=95% (HPLC);Brusatol (NSC 172924);Brusatol, 10 mM in DMSO
CBNumber
CB31342731
Molecular Formula
C26H32O11
Formula Weight
520.53
MOL File
14907-98-3.mol
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brusatol Property

Boiling point:
724.3±60.0 °C(Predicted)
Density 
1.46±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. 
-20°C
solubility 
DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
pka
8.81±0.70(Predicted)
form 
powder
color 
white to beige
biological source
(Brucia javanica)
optical activity
[α]/D +35 to +44°, c = 0.5 in acetone
InChIKey
ZZZYHIMVKOHVIH-YHSWLYNENA-N
LogP
0.393 (est)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1868
Product name
Brusatol
Purity
≥95% (HPLC)
Packaging
5MG
Price
$113
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1868
Product name
Brusatol
Purity
≥95% (HPLC)
Packaging
25MG
Price
$435.1
Updated
2025/07/31
TRC
Product number
B701056
Product name
(+)-Brusatol
Packaging
5mg
Price
$315
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB30016
Product name
Brusatol
Packaging
5mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-W019658
Product name
Brusatol
Purity
99.89%
Packaging
10mg
Price
$280
Updated
2021/12/16
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brusatol Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Brucea javanica.

Uses

Brusatol has been used to study the protective role of Nrf2 (nuclear factor, erythroid 2 like 2 ) in intestinal ischemia/reperfusion induced injury.

Definition

ChEBI: Brusatol is a triterpenoid.

Biochem/physiol Actions

Brusatol promotes Nrf2 (nuclear factor, erythroid 2 like 2 ) ubiquitination and degradation. Brusatol upregulates the expression of multiple ribosomal components and controls macromolecular complex function.

in vivo

Brusatol is able to reach the tumor tissue and inhibit the Nrf2 pathway. Nude mice are injected with A549 cells to induce tumor growth, followed by a single i.p. injection of 2 mg/kg Brusatol. Nrf2 protein levels are significantly decreased at 24 h or 48 h postinjection[1].
Cisplatin (2 mg/kg) or Brusatol (2 mg/kg) alone does not inhibit tumor growth significantly, whereas in the combination group, tumor size is significantly reduced[1]. "

Animal Model:Athymic nude mice 4-6 wk old bearing A549 xenografts[1]
Dosage:2 mg/kg
Administration:Treated i.p.; Cisplatin (2 mg/kg), Brusatol (2 mg/kg), or in combination every other day for a total of five times
Result:Nrf2 protein levels were significantly decreased at 24 h or 48 h postinjection.
Cisplatin or Brusatol alone did not inhibit tumor growth significantly, whereas in the combination group, tumor size was significantly reduced.?"

brusatol Preparation Products And Raw materials

Raw materials

Preparation Products

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brusatol Suppliers

China 159 India 2 United Kingdom 1 United States 9 USA 1 Global 172
CHEMSWORTH
Tel
--
Fax
--
Email
info@chemsworth.com
Country
India
ProdList
6700
Advantage
30
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from brusatol manufacturers

Henan Fengda Chemical Co., Ltd
Product
brusatol 14907-98-3
Price
US $8.00-0.80/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08
Career Henan Chemical Co
Product
brusatol 14907-98-3
Price
US $1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-24

14907-98-3, brusatolRelated Search:

bruceine D bruceine A (-)-13,20-Epoxy-1β,11β,12α,14,15β,21-hexahydroxypicrasa-3-ene-2,16-dione yadanziolide A bruceine B YADANZIOLIDE-C (+)-13,20-Epoxy-1β,6α,11β,12α,14,15β,21-heptahydroxypicrasa-3-ene-2,16-dione YADANZIOSIDE-L Methyl 2-tetrahydrofuroate Tetrahydropyranyl-4-acetic acid DL-2-METHYLGLUTAMIC ACID AZELAIC ACID MONOMETHYL ESTER 3,5,5-TRIMETHYLCYCLOHEXANE-1,2-DIONE OCTAHYDROCOUMARIN (-)-DIHYDROCARVYL ACETATE 1,11-Undecanedicarboxylic acid ISO-AMYL-SENECIOATE METHYL 3-ACETOXYHEXANOATE

  • 13,20-Epoxy-3,11β,12α-trihydroxy-15β-[(3-methyl-1-oxo-2-butenyl)oxy]-2,16-dioxopicras-3-en-21-oic acid methyl ester
  • 13,20-Epoxy-3,11β,12α-trihydroxy-15β-[(3-methyl-1-oxo-2-butenyl)oxy]-2,16-dioxopicrasa-3-ene-21-oic acid methyl ester
  • methyl (1R,2S,3S,3aS,3a1R,4R,6aR,7aR,11aS,11bR)-1,2,9-trihydroxy-8,11a-dimethyl-4-((3-methylbut-2-enoyl)oxy)-5,10-dioxo-1,4,5,6a,7,7a,10,11,11a,11b-decahydro-2H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-3(3aH)-carboxylate
  • Picras-3-en-21-oicacid,13,20-epoxy-3,11,12-trihydroxy-15-[(3-Methyl-1-oxo-2-buten-1-yl)oxy]-2,16-dioxo-,Methyl ester, (11b,12a,15b)-
  • NSC 172924
  • Yatansin
  • Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-buten-1-yl)oxy]-
  • Brustaol
  • 100935
  • Brusato1
  • Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-buten-1-yl)oxy]-2,16-dioxo-, methyl ester, (11β,12α,15β)-
  • Brusatol >=95% (HPLC)
  • (+)-Brusatol
  • (1R,2S,3S,3aS,3a1R,4R,6aR,7aR,11aS,11bR)-Methyl 1,2,9-trihydroxy-8,11a-dimethyl-4-((3-methylbut-2-enoyl)oxy)-5,10-dioxo-2,3,3a,4,5,6a,7,7a,10,11,11a,11b-dodecahydro-1H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-3-carboxylate
  • Brusatol (NSC 172924)
  • Brusatol, 10 mM in DMSO
  • Brusatol - Bio-X ?
  • 14907-98-3