ChemicalBook > CAS DataBase List > 3,5-Bis(trifluoromethyl)aniline

3,5-Bis(trifluoromethyl)aniline

Product Name
3,5-Bis(trifluoromethyl)aniline
CAS No.
328-74-5
Chemical Name
3,5-Bis(trifluoromethyl)aniline
Synonyms
3,5-DI(TRIFLUOROMETHYL)ANILINE;MBT-NH2;3,5-Bis(Trifluoro;AKOS BBS-00003710;TIMTEC-BB SBB000690;3,5-Di(trifluorometh;3,5-Bis(trifluormethyl)aniline;3,5-BIS(TRIFLUOROMETHYL)AMILINE;3,5-bis(trifluoromethyl)-anilin;3,5-BIS(TRIFLUOROMETHYL)ANILINE
CBNumber
CB3134320
Molecular Formula
C8H5F6N
Formula Weight
229.12
MOL File
328-74-5.mol
More
Less

3,5-Bis(trifluoromethyl)aniline Property

Melting point:
168.2-169.2 °C
Boiling point:
85 °C15 mm Hg(lit.)
Density 
1.467 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.434(lit.)
Flash point:
182 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
Liquid
pka
2.15±0.10(Predicted)
Specific Gravity
1.473
color 
Clear light yellow to yellow-brown
Water Solubility 
Not miscible in water.
BRN 
654318
InChIKey
CDIDGWDGQGVCIB-UHFFFAOYSA-N
CAS DataBase Reference
328-74-5(CAS DataBase Reference)
NIST Chemistry Reference
Benzenamine, 3,5-bis(trifluoromethyl)-(328-74-5)
EPA Substance Registry System
Benzenamine, 3,5-bis(trifluoromethyl)- (328-74-5)
More
Less

Safety

Hazard Codes 
Xi,Xn
Risk Statements 
33-36/37/38-20/21/22
Safety Statements 
26-36/37/39-36
RIDADR 
2810
WGK Germany 
3
RTECS 
ZE9800000
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214910
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
193135
Product name
3,5-Bis(trifluoromethyl)aniline
Purity
97%
Packaging
10g
Price
$52.5
Updated
2024/03/01
Sigma-Aldrich
Product number
193135
Product name
3,5-Bis(trifluoromethyl)aniline
Purity
97%
Packaging
50g
Price
$110
Updated
2024/03/01
TCI Chemical
Product number
B1324
Product name
3,5-Bis(trifluoromethyl)aniline
Purity
>97.0%(GC)
Packaging
10g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
B1324
Product name
3,5-Bis(trifluoromethyl)aniline
Purity
>97.0%(GC)
Packaging
25g
Price
$44
Updated
2024/03/01
Alfa Aesar
Product number
A15289
Product name
3,5-Bis(trifluoromethyl)aniline, 98%
Packaging
10g
Price
$23.65
Updated
2024/03/01
More
Less

3,5-Bis(trifluoromethyl)aniline Chemical Properties,Usage,Production

Chemical Properties

clear light yellow to yellow-brown liquid

Uses

3,5-Bis(trifluoromethyl)aniline was found to be a highly efficient monodentate transient directing group (MonoTDG) for the palladium-catalyzed direct dehydrogenative cross-coupling of benzaldehydes with arenes.

Synthesis

The synthesis of 3,5-Bis(trifluoromethyl)aniline is as follows is as follows：Put 259g (1mol) 3,5-Bis(trifluoromethyl)nitrobenzeneand 500g ethyl acetate into a 1L autoclave, add 5g palladium-carbon as a catalyst, raise the temperature to 60℃, then pass the hydrogen pressure to 2MPa, keep the temperature and react for 20 hours, then cooling, filtration, concentration, and distillation to obtain 3,5-Bis(trifluoromethyl)aniline with a purity of 98.5% and a yield of 87%.

3,5-Bis(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

Toluene Nitric acid

Preparation Products

5,7-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINE 5,7-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE 4-HYDROXY-5,7-BIS-TRIFLUOROMETHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 5,7-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID
More
Less

3,5-Bis(trifluoromethyl)aniline Suppliers

Americas 1 Belgium 2 Canada 2 China 311 Europe 5 France 1 Germany 8 India 13 Italy 1 Japan 6 Jordan 1 Slovakia 1 South Korea 1 Spain 1 Switzerland 2 The Netherlands 1 Ukraine 2 United Kingdom 26 United States 50 Global 435
AbaChemScene
Tel
732-484-9848
Fax
888-484-5008
Email
sales@chemscene.com
Country
United States
ProdList
3982
Advantage
60
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Aceschem Inc.
Tel
+1-817863-6948 +1-（817）863-6948
Email
sales@aceschem.com
Country
United States
ProdList
19632
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United States
ProdList
4583
Advantage
58
Ambeed, Inc.
Tel
--
Fax
--
Email
info@ambeed.com
Country
United States
ProdList
502
Advantage
58
SynQuest Laboratories, Inc.,
Tel
--
Fax
--
Country
United States
ProdList
2301
Advantage
58
Combi-Blocks, Inc.
Tel
--
Fax
--
Email
les@combi-blocks.com
Country
United States
ProdList
2555
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
SynQuest Laboratories, Inc. (Part of Central Glass Co., Ltd.)
Tel
--
Fax
--
Email
nfo@synquestlabs.com
Country
United States
ProdList
1897
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
Spectrum Chemical Mfg. Corp.
Tel
--
Fax
--
Email
marketing@spectrumchemical.com
Country
United States
ProdList
3113
Advantage
60
AA Blocks LLC
Tel
--
Fax
--
Email
s@aablocks.com
Country
United States
ProdList
536
Advantage
58
Accela ChemBio Inc.
Tel
--
Fax
--
Email
info@accelachem.com
Country
United States
ProdList
1054
Advantage
50
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
CarboMer, Inc.
Tel
--
Fax
--
Email
sales@carbomer.com
Country
United States
ProdList
4026
Advantage
67
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Ryan Scientific, Inc.
Tel
--
Fax
--
Email
ryan.reichlyn@ryansci.com
Country
United States
ProdList
6439
Advantage
60
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Narchem Corporation
Tel
--
Fax
--
Email
sales@narchem.com
Country
United States
ProdList
2813
Advantage
60
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
TimTec Corporation
Tel
--
Fax
--
Country
United States
ProdList
1945
Advantage
58
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
Accord Corporation
Tel
--
Fax
--
Email
info@accordchem.com
Country
United States
ProdList
225
Advantage
42
Wintersun Chemical
Tel
--
Fax
--
Email
purchasing@wintersunchem.com
Country
United States
ProdList
776
Advantage
68
R. K. Associate
Tel
--
Fax
--
Country
United States
ProdList
194
Advantage
30
Dishman Europe Ltd
Tel
--
Fax
--
Email
info@dishman-europe.com
Country
United States
ProdList
622
Advantage
58
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
ASDI Incorporated
Tel
--
Fax
--
Email
customerservice@asdi.net
Country
United States
ProdList
6922
Advantage
67
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
TimTec Corporation
Tel
--
Fax
--
Email
info@timtec.net
Country
United States
ProdList
6891
Advantage
68
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
AB Chem Technologies, LLC
Tel
--
Fax
--
Email
sales@abchemtech.com
Country
United States
ProdList
1101
Advantage
46
City Chemicals Corporation
Tel
--
Fax
--
Country
United States
ProdList
6460
Advantage
72
Marshallton Research Laboratories Inc.
Tel
--
Fax
--
Email
marshallton@windstream.net
Country
United States
ProdList
513
Advantage
59
More
Less

View Lastest Price from 3,5-Bis(trifluoromethyl)aniline manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
3,5-Bis(trifluoromethyl)aniline 328-74-5
Price
US $50.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20tons
Release date
2023-08-24
WUHAN FORTUNA CHEMICAL CO., LTD
Product
3,5-Bis(trifluoromethyl)aniline 328-74-5
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-24
Hebei Weibang Biotechnology Co., Ltd
Product
3,5-Bis(trifluoromethyl)aniline 328-74-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-19

328-74-5, 3,5-Bis(trifluoromethyl)anilineRelated Search:

3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-2,5-DIMETHYL-1H-PYRROLE 3,5-Bis(trifluoromethyl)aniline 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-2-THIOUREA 3,5-BIS(TRIFLUOROMETHYL)ACETANILIDE 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]PYRROLE 3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOCYANATE 3,5-BIS(TRIFLUOROMETHYL)PHENYLHYDRAZINE 2,5-Bis(trifluoromethyl)nitrobenzene 4-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-3-THIOSEMICARBAZIDE 2,5-DI(TRIFLUOROMETHYL)ANILINE Aniline 2-CHLORO(BIS-3',5'-TRIFLUOROMETHYLACETANILIDE) N1-[2-(2-PIPERIDYL)ETHYL]-3,5-DI(TRIFLUOROMETHYL)ANILINE 2-AMINO-4-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]AMINO-1,3,5-TRIAZINE 2-BROMO-4,5-DI(TRIFLUOROMETHYL)ANILINE 2-METHYL-3,5-DI(TRIFLUOROMETHYL)ANILINE N1-methyl-3,5-di(trifluoromethyl)aniline

  • ,,,’,’,’-Hexafluoro-3,5-xylidine
  • ,5-Bis-trifluoromethyl-phenylamine
  • ,5-Xylidine, a,a,a,a',a',a'-hexafluoro-
  • ,a,a,a',a',a'-Hexafluoro-3,5-xylidine
  • 3,5-bis(trifluoromethyl)-anilin
  • 3,5-bis(trifluoromethyl)-benzenamin
  • 3,5-Bis(trifluoromethyl)benzenamine
  • 3,5-Di(trifluorometh
  • 3,5-DI(TRIFLUOROMETHYL)ANILINE
  • 5-AMINO-ALPHA,ALPHA,ALPHA,ALPHA',ALPHA',ALPHA'-HEXAFLUORO-M-XYLENE
  • 3,5-BIS(TRIFLUOROMETHYL)AMILINE
  • 3,5-Bis(trifluoromethyl)aniline, 98+%
  • 3,5-Bis(Trifluoro
  • 5-amino-α,α,α,α',α',α'-hexafluoro-m-xylene
  • 5-Amino-α,α,α,αμ,αμ,αμ-hexafluoro-m-xylene, α,α,α,αμ,αμ,αμ-Hexafluoro-3,5-xylidine
  • 3,5-Bis(trifluoromethyl)benzeneamine
  • 3,5-Bis(trifluoroMethyl)aniline, 98+% 10ML
  • 3,5- two(three fluoroMethyl)aniline
  • 3, 5 - double three fluorine Methylaniline
  • 3,5-Xylidine, alpha,alpha,alpha,alpha',alpha',alpha'-hexafluoro-
  • 3,5-Xylidine, alpha,alpha,alpha,alpha,alpha,alpha-hexafluro-
  • alpha,alpha,alpha,alpha’,alpha’,alpha’-hexafluoro-5-xylidine
  • Aniline, 3,5-bis(trifluoromethyl)-
  • TIMTEC-BB SBB000690
  • MBT-NH2
  • ALPHA,ALPHA,ALPHA,ALPHA',ALPHA',ALPHA'-HEXAFLUORO-3,5-XYLIDINE
  • AKOS BBS-00003710
  • A,A,A,A',A',A'-HEXAFLUORO-3,5-XYLIDINE
  • 3,5-BIS(TRIFLUOROMETHYL)ANILINE
  • 3,5-Bis(trifluoromethyl)aniline &gt
  • Benzenamine, 3,5-bis(trifluoromethyl)-
  • α,α,α,α',α',α'-Hexafluor-3,5-xylidin
  • 3,5-Di(trifluoromethyl)aniline CAS NO.328-74-5
  • 3,5-Bis(trifluormethyl)aniline
  • 328-74-5
  • C8H5NF6
  • Organic Building Blocks
  • Nitrogen Compounds
  • Amines
  • Building Blocks
  • C8
  • Aniline series
  • Fluorobenzene
  • Anilines, Aromatic Amines and Nitro Compounds
  • Miscellaneous
  • Trifluoromethylbenzene serise