HIRUDIN (54-65) (DESULFATED)

Description Source Background

Product Name: HIRUDIN (54-65) (DESULFATED)
CAS No.: 113274-56-9
Chemical Name: HIRUDIN (54-65) (DESULFATED)
Synonyms: Hirudin;GDFEEIPEEYLQ;Exhirud，Exhirudine，Hirudex;HIRUDIN (54-65) (DESULFATED);Hirudin(54-65),700-900 ATU/g;HIRUDIN FRAGMENT 54-65 NON-SULFATED;HIRUDIN (54-65) (DESULFATED) USP/EP/BP;113274-56-9---HIRUDIN (54-65) (DESULFATED);GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR-LEU-GLN;H-GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR-LEU-GLN-OH
CBNumber: CB3140840
Molecular Formula: C66H93N13O25
Formula Weight: 1468.52
MOL File: 113274-56-9.mol

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HIRUDIN (54-65) (DESULFATED) Property

Boiling point:: 1913.6±65.0 °C(Predicted)
Density: 1.384±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka: 3.25±0.10(Predicted)
Sequence: H-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-Gln-OH
InChIKey: ZNEKMMIWGPUTGR-YDNADGHJNA-N
LogP: -0.190 (est)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: H4080B
Product name: Hirudin
Packaging: 200ug
Price: $462
Updated: 2021/12/16

Usbiological

Product number: H4080-01
Product name: Hirudin
Packaging: 1mg
Price: $531
Updated: 2021/12/16

Usbiological

Product number: H4080-01A
Product name: Hirudin
Packaging: 1mg
Price: $531
Updated: 2021/12/16

Usbiological

Product number: H4080-01B
Product name: Hirudin
Packaging: 1mg
Price: $531
Updated: 2021/12/16

Usbiological

Product number: H4080-01C
Product name: Hirudin
Packaging: 1mg
Price: $531
Updated: 2021/12/16

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HIRUDIN (54-65) (DESULFATED) Chemical Properties,Usage,Production

Chemical Properties

Hirudin is the strongest thrombin retarder so far. It fuses with thrombin to produce a non-covalent nitric oxide synthase with a dissociation constant of the order of 10-12 and a very fast reaction rate. quick. Hirudin and thrombin have strong infectivity, 1μg can neutralize 5μg thrombin, and the molar ratio is 1:1.

Uses

Hirudin is a small protein (polypeptide) composed of 65-66 amino acids. Hirudin has a strong inhibitory effect on thrombin and is the strongest natural specific inhibitor of thrombin found so far.

Description

Recombinant Hirudin is derived from yeast and the polypeptide chain contains 65 amino acids and its Mw is 6979.5 Dalton which is identical to natural Hirudin except for the substitution of leucine for isoleucine at the N-terminal end of the molecule and the absence of a sulfate group on the tyrosine at position 63.
The Recombinant Hirudin is purified by proprietary chromatographic techniques.

Source

Pichia Pastoris

Background

Recombinant Hirudin is a potent thrombin inhibitor originally derived from the medicinal leech. Hirudin acts directly on thrombin rather than through other clotting factors. The mechanism of Hirudin-thrombin appears to be unique. The conversion of fibrinogen into fibrin by the serine protease enzyme thrombin is a major event in the final stages of blood coagulation. In the final stages of coagulation prothrombinase converts prothrombin into thrombin. Fibrin is subsequently cross linked by factor XIII to form a blood clot. The primary inhibitor of thrombin in normal blood circulation is antithrombin III. The anticoagulatant activity of hirudin is derived from its ability to inhibit the pro-coagulant activity of thrombin (similar to antithrombin III activity). Hirudin is the strongest natural inhibitor of thrombin. Hirudin binds to and inhibits only the activity of thrombin forms with a specific activity on fibrinogen contrasting to antithrombin III activity. Therefore, hirudin has a thrombolytic activity since it prevents or dissolves the formation of clots and thrombi. Hirudin also has therapeutic significance in blood coagulation disorders, in the treatment of skin hematomas and of superficial varicose veins. Hirudin does not hinder with the biological activity of other serum proteins and can also act on complexed thrombin, thus having an advantage over more common anticoagulants and thrombolytics. It is complicated to extract large quantities of hirudin from natural sources; therefore a method for producing and purifying hirudin using recombinant biotechnology has been developed.

HIRUDIN (54-65) (DESULFATED) Preparation Products And Raw materials

Raw materials

Preparation Products

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HIRUDIN (54-65) (DESULFATED) Suppliers

China 203 Switzerland 1 United Kingdom 1 United States 10 Global 215

BOC Sciences

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View Lastest Price from HIRUDIN (54-65) (DESULFATED) manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.

Product: HIRUDIN (54-65) (DESULFATED) 113274-56-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98% HPLC
Supply Ability: 1000kg
Release date: 2022-10-11

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: HIRUDIN (54-65) (DESULFATED) 113274-56-9
Price: US $60.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-06-11

Sigma Audley

Product: HIRUDIN (54-65) (DESULFATED) 113274-56-9
Price: US $35.00-25.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 200tons/year
Release date: 2024-03-15

113274-56-9, HIRUDIN (54-65) (DESULFATED)Related Search:

TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Cupric acetylacetonate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Benzyl isocyanide 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Aluminum acetylacetonate SALCOMINE Tosylmethyl isocyanide METHYL ISOCYANOACETATE N-BUTYLISOCYANIDE HIRUDIN (54-65) (DESULFATED) Lepirudin TERT-BUTYL ISOCYANIDE Ethyl isocyanoacetate Ferric acetylacetonate PHENYLSELENOL

HIRUDIN (54-65) (DESULFATED)

HIRUDIN FRAGMENT 54-65 NON-SULFATED

H-GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR-LEU-GLN-OH

GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR-LEU-GLN

Hirudin

GDFEEIPEEYLQ

L-Glutamine, glycyl-L-α-aspartyl-L-phenylalanyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-α-glutamyl-L-α-glutamyl-L-tyrosyl-L-leucyl-

HIRUDIN (54-65) (DESULFATED) USP/EP/BP

113274-56-9---HIRUDIN (54-65) (DESULFATED)

Exhirud，Exhirudine，Hirudex

L-Glutamine, glycyl-L-a-aspartyl-L-phenylalanyl-L-a-glutamyl-L-a-glutamyl-L-isoleucyl-L-prolyl-L-a-glutamyl-L-a-glutamyl-L-tyrosyl-L-leucyl-(9CI)

Hirudin(54-65),700-900 ATU/g

113274-56-9

C66H93N13O25

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