ChemicalBook > CAS DataBase List > 5-Bromo-3-cyano-2-methoxypyridine

5-Bromo-3-cyano-2-methoxypyridine

Uses

Product Name: 5-Bromo-3-cyano-2-methoxypyridine
CAS No.: 941294-54-8
Chemical Name: 5-Bromo-3-cyano-2-methoxypyridine
Synonyms: 5-Bromo-2-methoxynicotinonitrile;3-Bromo-5-cyano-6-methoxypyridine;5-Bromo-3-cyano-2-methoxypyridine;5-Bromo-2-methoxynicotinonitrile98%;5-bromo-2-methoxypyridine-3-carbonitrile;5-Bromo-2-methoxy-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 5-bromo-2-methoxy-;5-Bromo-2-methoxypyridine-3-carbonitrile, 5-Bromo-3-cyano-2-methoxypyridine
CBNumber: CB31457516
Molecular Formula: C7H5BrN2O
Formula Weight: 213.03
MOL File: 941294-54-8.mol

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5-Bromo-3-cyano-2-methoxypyridine Property

Melting point:: 110-115°C
Boiling point:: 267℃
Density: 1.65
Flash point:: 115℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: solid
pka: -2.40±0.20(Predicted)
color: white

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Safety

Hazard Codes: Xi,T
Risk Statements: 25-36/37/38
Safety Statements: 26-36-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 739146
Product name: 5-Bromo-2-methoxypyridine-3-carbonitrile
Purity: 97%
Packaging: 1g
Price: $81.4
Updated: 2023/06/20

TRC

Product number: B696758
Product name: 5-Bromo-2-methoxynicotinonitrile
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: B696758
Product name: 5-Bromo-2-methoxynicotinonitrile
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B696758
Product name: 5-Bromo-2-methoxynicotinonitrile
Packaging: 250mg
Price: $55
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H37-9-Z5
Product name: 5-Bromo-2-methoxynicotinonitrile
Purity: 98%
Packaging: 1g
Price: $59
Updated: 2021/12/16

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5-Bromo-3-cyano-2-methoxypyridine Chemical Properties,Usage,Production

Uses

5-Bromo-2-methoxynicotinonitrile can be used as a pharmaceutical synthesis intermediate.

Synthesis

7254-34-4

941294-54-8

General procedure for the synthesis of 5-bromo-3-cyano-2-methoxypyridine from 3-cyano-2-methoxypyridine: 12.23 g (149 mmol) of sodium acetate and 7.66 mL (149 mmol) of bromine were added drop-wise to 29 mL of acetic acid solution containing 10 g (74.6 mmol) of 3-cyano-2-methoxypyridine at 0 °C. The reaction mixture was then heated at 70 °C for overnight reaction. Upon completion of the reaction, the reaction system was cooled to room temperature and poured into an ice bath. The precipitated solid product was collected by filtration, washed thoroughly with water and dried at 50 °C to afford 11.6 g (73% yield) of the target compound 5-bromo-3-cyano-2-methoxypyridine as a white solid. The product was analyzed by LC-MS (EI, m/z) to confirm: (M+1) 214.95. 1H NMR (400 MHz, DMSO-d6) δ: 8.61 (1H, d, J = 2.4 Hz, Ar-H), 8.60 (1H, d, J = 2.4 Hz, Ar-H), 3.98 (3H, s, OCH3).

References

[1] Patent: WO2012/101239, 2012, A1. Location in patent: Page/Page column 55
[2] Patent: US2013/85144, 2013, A1. Location in patent: Paragraph 0281; 0282; 0283
[3] Patent: EP2689778, 2014, A1. Location in patent: Paragraph 0185
[4] Patent: WO2014/16433, 2014, A1. Location in patent: Page/Page column 54
[5] Patent: WO2014/16434, 2014, A1. Location in patent: Page/Page column 53-54

5-Bromo-3-cyano-2-methoxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-3-cyano-2-methoxypyridine Suppliers

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View Lastest Price from 5-Bromo-3-cyano-2-methoxypyridine manufacturers

Career Henan Chemical Co

Product: 5-Bromo-3-cyano-2-methoxypyridine 941294-54-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: KG/T
Release date: 2019-12-18

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5-Bromo-3-cyano-2-methoxypyridine

941294-54-8

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Bromides

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Pyridines