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ChemicalBook > CAS DataBase List > 5-Bromo-3-cyano-2-methoxypyridine

5-Bromo-3-cyano-2-methoxypyridine

Uses
Product Name
5-Bromo-3-cyano-2-methoxypyridine
CAS No.
941294-54-8
Chemical Name
5-Bromo-3-cyano-2-methoxypyridine
Synonyms
5-Bromo-2-methoxynicotinonitrile;3-Bromo-5-cyano-6-methoxypyridine;5-Bromo-3-cyano-2-methoxypyridine;5-Bromo-2-methoxynicotinonitrile98%;5-bromo-2-methoxypyridine-3-carbonitrile;5-Bromo-2-methoxy-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 5-bromo-2-methoxy-;5-Bromo-2-methoxypyridine-3-carbonitrile, 5-Bromo-3-cyano-2-methoxypyridine
CBNumber
CB31457516
Molecular Formula
C7H5BrN2O
Formula Weight
213.03
MOL File
941294-54-8.mol
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5-Bromo-3-cyano-2-methoxypyridine Property

Melting point:
110-115°C
Boiling point:
267℃
Density 
1.65
Flash point:
115℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
solid
pka
-2.40±0.20(Predicted)
color 
white
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Safety

Hazard Codes 
Xi,T
Risk Statements 
25-36/37/38
Safety Statements 
26-36-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
739146
Product name
5-Bromo-2-methoxypyridine-3-carbonitrile
Purity
97%
Packaging
1g
Price
$81.4
Updated
2023/06/20
TRC
Product number
B696758
Product name
5-Bromo-2-methoxynicotinonitrile
Packaging
500mg
Price
$65
Updated
2021/12/16
TRC
Product number
B696758
Product name
5-Bromo-2-methoxynicotinonitrile
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
B696758
Product name
5-Bromo-2-methoxynicotinonitrile
Packaging
250mg
Price
$55
Updated
2021/12/16
SynQuest Laboratories
Product number
4H37-9-Z5
Product name
5-Bromo-2-methoxynicotinonitrile
Purity
98%
Packaging
1g
Price
$59
Updated
2021/12/16
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5-Bromo-3-cyano-2-methoxypyridine Chemical Properties,Usage,Production

Uses

5-Bromo-2-methoxynicotinonitrile can be used as a pharmaceutical synthesis intermediate.

Synthesis

7254-34-4

941294-54-8

General procedure for the synthesis of 5-bromo-3-cyano-2-methoxypyridine from 3-cyano-2-methoxypyridine: 12.23 g (149 mmol) of sodium acetate and 7.66 mL (149 mmol) of bromine were added drop-wise to 29 mL of acetic acid solution containing 10 g (74.6 mmol) of 3-cyano-2-methoxypyridine at 0 °C. The reaction mixture was then heated at 70 °C for overnight reaction. Upon completion of the reaction, the reaction system was cooled to room temperature and poured into an ice bath. The precipitated solid product was collected by filtration, washed thoroughly with water and dried at 50 °C to afford 11.6 g (73% yield) of the target compound 5-bromo-3-cyano-2-methoxypyridine as a white solid. The product was analyzed by LC-MS (EI, m/z) to confirm: (M+1) 214.95. 1H NMR (400 MHz, DMSO-d6) δ: 8.61 (1H, d, J = 2.4 Hz, Ar-H), 8.60 (1H, d, J = 2.4 Hz, Ar-H), 3.98 (3H, s, OCH3).

References

[1] Patent: WO2012/101239, 2012, A1. Location in patent: Page/Page column 55
[2] Patent: US2013/85144, 2013, A1. Location in patent: Paragraph 0281; 0282; 0283
[3] Patent: EP2689778, 2014, A1. Location in patent: Paragraph 0185
[4] Patent: WO2014/16433, 2014, A1. Location in patent: Page/Page column 54
[5] Patent: WO2014/16434, 2014, A1. Location in patent: Page/Page column 53-54

5-Bromo-3-cyano-2-methoxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-3-cyano-2-methoxypyridine Suppliers

China 75 India 1 Switzerland 1 United Kingdom 1 United States 10 Global 88
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from 5-Bromo-3-cyano-2-methoxypyridine manufacturers

Career Henan Chemical Co
Product
5-Bromo-3-cyano-2-methoxypyridine 941294-54-8
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
KG/T
Release date
2019-12-18

941294-54-8, 5-Bromo-3-cyano-2-methoxypyridineRelated Search:

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  • 5-Bromo-2-methoxynicotinonitrile
  • 5-bromo-2-methoxypyridine-3-carbonitrile
  • 5-Bromo-2-methoxypyridine-3-carbonitrile, 5-Bromo-3-cyano-2-methoxypyridine
  • 5-Bromo-2-methoxy-3-pyridinecarbonitrile
  • 3-Bromo-5-cyano-6-methoxypyridine
  • 5-Bromo-2-methoxynicotinonitrile98%
  • 3-Pyridinecarbonitrile, 5-bromo-2-methoxy-
  • 5-Bromo-3-cyano-2-methoxypyridine
  • 941294-54-8
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  • Bromides
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