2-Bromo-1-(3-fluorophenyl)ethan-1-one
- Product Name
- 2-Bromo-1-(3-fluorophenyl)ethan-1-one
- CAS No.
- 53631-18-8
- Chemical Name
- 2-Bromo-1-(3-fluorophenyl)ethan-1-one
- Synonyms
- ethan-1-one;BUTTPARK 35\01-52;3-FLUOROPHENACYL BROMIDE;3-Fluorophenacylbromide95%;2-Bromo-1-(3-fluorophenyl);3-Fluorophenacyl bromide 95%;3-Fluorophenacyl bromide ,97%;2-Bromo-3'-fluoroacetophenone;ALPHA-BROMO-3-FLUOROACETOPHENONE;2-Bromo-3'-fluoroacetophenone 97%
- CBNumber
- CB3147915
- Molecular Formula
- C8H6BrFO
- Formula Weight
- 217.04
- MOL File
- 53631-18-8.mol
2-Bromo-1-(3-fluorophenyl)ethan-1-one Property
- Melting point:
- 34-35
- Boiling point:
- 76°C 0,09mm
- Density
- 1.568±0.06 g/cm3(Predicted)
- Flash point:
- 110 °C
- storage temp.
- 2-8°C
- form
- solid
- color
- Faint to light yellow
- Sensitive
- Lachrymatory
- InChI
- InChI=1S/C8H6BrFO/c9-5-8(11)6-2-1-3-7(10)4-6/h1-4H,5H2
- InChIKey
- ITAQNNGDCNFGID-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=CC=CC(F)=C1)CBr
- CAS DataBase Reference
- 53631-18-8(CAS DataBase Reference)
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 36/37/38-34
- Safety Statements
- 26-36/37/39-45-27
- RIDADR
- UN 3335
- WGK Germany
- 3
- Hazard Note
- Corrosive/Lachrymatory/Keep Cold
- HazardClass
- LACHRYMATOR, CORROSIVE
- HS Code
- 29147000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 669482
- Product name
- 2-Bromo-3′-fluoroacetophenone
- Purity
- 97%
- Packaging
- 1g
- Price
- $47.2
- Updated
- 2025/07/31
- Product number
- 669482
- Product name
- 2-Bromo-3′-fluoroacetophenone
- Purity
- 97%
- Packaging
- 5g
- Price
- $140
- Updated
- 2023/06/20
- Product number
- B6512
- Product name
- 2-Bromo-1-(3-fluorophenyl)ethanone
- Purity
- min. 95.0 %
- Packaging
- 1G
- Price
- $55
- Updated
- 2025/07/31
- Product number
- B6512
- Product name
- 2-Bromo-1-(3-fluorophenyl)ethanone
- Purity
- min. 95.0 %
- Packaging
- 5G
- Price
- $165
- Updated
- 2025/07/31
- Product number
- B693013
- Product name
- 2-Bromo-1-(3-fluorophenyl)ethan-1-one
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
2-Bromo-1-(3-fluorophenyl)ethan-1-one Chemical Properties,Usage,Production
Chemical Properties
White solid
Synthesis
455-36-7
53631-18-8
GENERAL METHODS: Oxone (1.352 g, 2.2 mmol) was added to a well-stirred methanol (10 mL) solution of m-fluoroacetophenone (2 mmol) and NH4Br (0.215 g, 2.2 mmol) and the reaction mixture was stirred at room temperature (or reflux temperature). The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was quenched with aqueous sodium thiosulfate and extracted with ethyl acetate (3 × 25 mL). The organic layers were combined, washed with water, dried over anhydrous sodium sulfate, filtered, and concentrated in vacuum to remove the solvent to give the crude product. The crude product was further purified by silica gel column chromatography (200-300 mesh) to give pure 2-bromo-3'-fluoroacetophenone. All products were structurally confirmed by 1H NMR and mass spectrometry data.
References
[1] Tetrahedron Letters, 2012, vol. 53, # 2, p. 191 - 195
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 15, p. 6572 - 6582
[3] Patent: WO2008/46598, 2008, A1. Location in patent: Page/Page column 92
[4] RSC Advances, 2014, vol. 4, # 107, p. 62308 - 62320
[5] Journal of Organic Chemistry, 2013, vol. 78, # 14, p. 7312 - 7317
2-Bromo-1-(3-fluorophenyl)ethan-1-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-1-(3-fluorophenyl)ethan-1-one manufacturers
- Product
- 2-Bromo-1-(3-fluorophenyl)ethanone 53631-18-8
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 2-Bromo-1-(3-fluorophenyl)ethan-1-one 53631-18-8
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100g , 1kg, 5kg , 50kg
- Release date
- 2020-01-07