ChemicalBook > CAS DataBase List > Betaxolol hydrochloride

Betaxolol hydrochloride

Product Name
Betaxolol hydrochloride
CAS No.
63659-19-8
Chemical Name
Betaxolol hydrochloride
Synonyms
Kerlon;kerlone;SL 75212;betoptic;sl-d.212;Betaxolo;Betoptima;sl75212-10;SL 75212 HCl;Betaxolol HC
CBNumber
CB3153329
Molecular Formula
C18H30ClNO3
Formula Weight
343.89
MOL File
63659-19-8.mol
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Betaxolol hydrochloride Property

Melting point:
116°
storage temp. 
2-8°C
solubility 
H2O: 36 mg/mL, soluble
form 
solid
color 
white
Water Solubility 
Soluble to 50 mM in water
Merck 
14,1182
Stability:
Hygroscopic
InChI
InChI=1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16;/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;1H
InChIKey
CHDPSNLJFOQTRK-UHFFFAOYSA-N
SMILES
C1(OCC(O)CNC(C)C)C=CC(CCOCC2CC2)=CC=1.Cl
CAS DataBase Reference
63659-19-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
RTECS 
UA9823000
HS Code 
2922504500
Toxicity
LD50 in mice (mg/kg): 944 orally; 37 i.v. (Manoury)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0001360
Product name
Betaxolol for peak identification
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
15 mg
Price
$118
Updated
2025/07/31
Sigma-Aldrich
Product number
B5683
Product name
Betaxolol hydrochloride
Purity
>98% (HPLC)
Packaging
10mg
Price
$137.2
Updated
2025/07/31
Sigma-Aldrich
Product number
BP686
Product name
Betaxolol hydrochloride
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100 mg
Price
$234
Updated
2025/07/31
Sigma-Aldrich
Product number
B1103000
Product name
Betaxolol hydrochloride
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
60 mg
Price
$153
Updated
2025/07/31
Sigma-Aldrich
Product number
1069903
Product name
Betaxolol hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$425
Updated
2025/07/31
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Betaxolol hydrochloride Chemical Properties,Usage,Production

Description

Betaxolol (hydrochloride) (Item No. 26285) is an analytical reference standard categorized as a β1-adrenergic receptor antagonist. Formulations containing β-adrenergic receptor antagonists have been used to enhance physical performance in athletes. This product is intended for use in analytical forensic applications. This product is also available as a general research tool .

Description

Betaxolol hydrochloride is a cardioselective β-adrenergic blocker, reportedly devoid of intrinsic sympathomimetic and membrane stabilizing properties. Its long duration of action permits once-daily dosing in mild to moderate hypertension. It is also being evaluated in glaucoma.

Chemical Properties

White or almost white, crystalline powder.

Originator

Synthelabo (France)

Uses

antifungal

Uses

Betaxolol Hydrochloride, a cardioselective β1-adrenergic blocker. An antihypertensive; antiglaucoma.

Definition

ChEBI: The hydrochloride salt of betaxolol.

brand name

Betoptic (Alcon); Kerlone (Sanofi Aventis).

Biological Activity

Selective β 1 -adrenoceptor antagonist.

storage

Store at RT

References

[1] SEUNG-WOON MYUNG  Cheon H J. Gas chromatograph–mass spectrometric method for the determination of carvedilol and its metabolites in human urine[J]. Journal of Chromatography B, 2005, 822 1: Pages 70-77. DOI: 10.1016/j.jchromb.2005.05.023
[2] PANKAJ GUPTA R G. Amino Functionalized Graphene Oxide and Polymer Nanocomposite Based Electrochemical Platform for Sensitive Assay of Anti-Doping Drug Atenolol in Biological Fluids[J]. Journal of The Electrochemical Society, 2016, 163 1. DOI: 10.1149/2.0281613jes
[3] A WELLSTEIN  G G B  D Palm. Affinity and selectivity of beta-adrenoceptor antagonists in vitro.[J]. Journal of Cardiovascular Pharmacology, 1986, 8 Suppl 11: S36-40. DOI: 10.1097/00005344-198511001-00006
[4] DOROTA POZAROWSKA  Zbigniew D  Piotr Pozarowski. Cytometric assessment of cytostatic and cytotoxic effects of topical glaucoma medications on human epithelial corneal line cells?[J]. Cytometry Part B: Clinical Cytometry, 2009, 78B 2: 130-137. DOI: 10.1002/cyto.b.20493
[5] N. SHARIF. Levobetaxolol (Betaxon) and other beta-adrenergic antagonists: preclinical pharmacology, IOP-lowering activity and sites of action in human eyes.[J]. Journal of Ocular Pharmacology and Therapeutics, 2001, 26 1: 305-317. DOI: 10.1089/108076801753162726
[6] GLYN CHIDLOW  Neville N O  José Melena. Betaxolol, a β1-adrenoceptor antagonist, reduces Na+ influx into cortical synaptosomes by direct interaction with Na+ channels: comparison with other β-adrenoceptor antagonists[J]. British Journal of Pharmacology, 2009, 130 4: 759-766. DOI: 10.1038/sj.bjp.0703369

Betaxolol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Betaxolol hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Betaxolol hydrochloride 63659-19-8
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
99%min
Supply Ability
500KGS
Release date
2021-09-13
Hebei Chuanghai Biotechnology Co,.LTD
Product
Betaxolo hydrochloride 63659-19-8
Price
US $1.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-20
Hebei Zhanyao Biotechnology Co. Ltd
Product
Betaxolol hydrochloride 63659-19-8
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-11-17

63659-19-8, Betaxolol hydrochlorideRelated Search:


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