ChemicalBook > CAS DataBase List > 3-Bromophthalide
3-Bromophthalide
Uses- Product Name
- 3-Bromophthalide
- CAS No.
- 6940-49-4
- Chemical Name
- 3-Bromophthalide
- Synonyms
- TALM-002;3-BromophthaL;BROMOPHTHALIDE;3-Bromophtalide;3-BROMOPHTHALIDE;3-bromophthalein;3-Bromophthalide97%;3-Bromophthalide 3-;3-Bromophthalide >3-BROMOPHTHALIDE 98+%
- CBNumber
- CB3157574
- Molecular Formula
- C8H5BrO2
- Formula Weight
- 213.03
- MOL File
- 6940-49-4.mol
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3-Bromophthalide Property
- Melting point:
- 86°C
- Boiling point:
- 138 °C / 3mmHg
- Density
- 1.768±0.06 g/cm3(Predicted)
- Flash point:
- >100°
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- soluble in Methanol
- form
- powder to crystal
- color
- White to Light yellow to Light orange
- InChI
- InChI=1S/C8H5BrO2/c9-7-5-3-1-2-4-6(5)8(10)11-7/h1-4,7H
- InChIKey
- CLMSHAWYULIVFQ-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=CC=C2)C(Br)O1
- CAS DataBase Reference
- 6940-49-4(CAS DataBase Reference)
- EPA Substance Registry System
- 1(3H)-Isobenzofuranone, 3-bromo- (6940-49-4)
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Safety
- Risk Statements
- 38-41
- Safety Statements
- 26-36/37/39
- HS Code
- 2932209090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- B1068
- Product name
- 3-Bromophthalide
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $55
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B1068
- Product name
- 3-Bromophthalide
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $144
- Updated
- 2025/07/31
Oakwood
- Product number
- 113900
- Product name
- 3-Bromophthalide
- Purity
- 97%
- Packaging
- 100g
- Price
- $390
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB33933
- Product name
- 3-Bromophthalide
- Packaging
- 250g
- Price
- $292.5
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB33933
- Product name
- 3-Bromophthalide
- Packaging
- 50g
- Price
- $67.5
- Updated
- 2021/12/16
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3-Bromophthalide Chemical Properties,Usage,Production
Uses
3-Bromophthalide is a major intermediate in the synthesis of drugs such as tannic acid ester and phthalimide. Further hydrolysis of 3-bromophthalide can yield o-sylbenzaldehyde, which is an important intermediate in the synthesis of antipyretic analgesics.
Synthesis
3-Bromophthalide is produced by reacting phthalide with N-bromosuccinimide in carbon tetrachloride solution.
Ten grams (0.075 mole) of phthalide (Note 1), 13.3 g. (0.075 mole) of N-bromosuccinimide, and 200 ml. of dry carbon tetrachloride are refluxed for 30 minutes in a 500-ml. flask carrying a reflux condenser equipped with a drying tube containing Drierite. The reaction mixture is exposed to the light of an ordinary 100-watt unfrosted light bulb placed 6–8 in. from the flask. The end of the reaction is indicated by the disappearance of N-bromosuccinimide from the bottom of the flask and accumulation of succinimide at the top of the reaction mixture. The succinimide is removed by filtration and the filtrate concentrated under atmospheric pressure to 15–20 ml. Cooling of this concentrate followed by filtration gives 12–13 g. (75–81%) of crude 3-bromophthalide, m.p. 74–80°. The crude material, when recrystallized from cyclohexane, gives colorless plates, m.p. 78–80°.
References
[1] Patent: US4960902, 1990, A
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999, vol. 38, # 7, p. 810 - 813
[3] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000, vol. 39, # 6, p. 455 - 457
[4] Synlett, 2003, # 5, p. 702 - 704
[5] Chemical and Pharmaceutical Bulletin, 1983, vol. 31, # 8, p. 2698 - 2707
3-Bromophthalide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Bromophthalide manufacturers
ShenZhen H&D Pharmaceutical Technology Co., LTD
- Product
- Butyphthalide impurity 88 6940-49-4
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 5g
- Release date
- 2024-05-24
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
- Product
- 3-Bromophthalide 6940-49-4
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-12-30
Hebei Zhanyao Biotechnology Co. Ltd
- Product
- 3-Bromophthalide 6940-49-4
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2021-10-08
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