Diethyl ethoxymethylenemalonate
- Product Name
- Diethyl ethoxymethylenemalonate
- CAS No.
- 87-13-8
- Chemical Name
- Diethyl ethoxymethylenemalonate
- Synonyms
- EMME;Diethyl 2-(ethoxymethylene)malonate;Diethyl 2-(ethoxymethylene)propanedioate;DEEMM;ETHOXYMETHYLENEMALONIC ACID DIETHYL ESTER;onate;2-Ethoxymethylene-malonic acid diethyl ester;tl1483;enemaL;NSC 9068
- CBNumber
- CB3163908
- Molecular Formula
- C10H16O5
- Formula Weight
- 216.23
- MOL File
- 87-13-8.mol
Diethyl ethoxymethylenemalonate Property
- Melting point:
- -33°C
- Boiling point:
- 279-283 °C(lit.)
- Density
- 1.080 g/mL at 20 °C(lit.)
- vapor pressure
- <0.1 hPa
- refractive index
- n20/D 1.463
- Flash point:
- 311 °F
- storage temp.
- Store below +30°C.
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Liquid
- color
- Clear colorless to light yellow
- Water Solubility
- insoluble
- BRN
- 880058
- InChIKey
- LTMHNWPUDSTBKD-UHFFFAOYSA-N
- LogP
- 1.5-2.1 at pH7
- CAS DataBase Reference
- 87-13-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Propanedioic acid, (ethoxymethylene)-, diethyl ester(87-13-8)
- EPA Substance Registry System
- Propanedioic acid, (ethoxymethylene)-, diethyl ester (87-13-8)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38-42/43
- Safety Statements
- 26-36/37/39-27-24/25
- WGK Germany
- 1
- RTECS
- OO1100000
- Autoignition Temperature
- 215 °C
- TSCA
- Yes
- HS Code
- 29189090
- Toxicity
- LD50 orally in Rabbit: 925 mg/kg LD50 dermal Rat > 2000 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Y0001792
- Product name
- Nalidixic acid impurity C
- Purity
- EuropePharmacopoeia (EP) Reference Standard
- Packaging
- Y0001792
- Price
- $204
- Updated
- 2022/05/15
- Product number
- 05689
- Product name
- Diethyl ethoxymethylenemalonate
- Purity
- for LC-MS derivatization, ≥98.0% (GC)
- Packaging
- 1ml
- Price
- $31
- Updated
- 2022/05/15
- Product number
- E0255
- Product name
- Diethyl Ethoxymethylenemalonate
- Purity
- >98.0%(GC)
- Packaging
- 25mL
- Price
- $21
- Updated
- 2024/03/01
- Product number
- E0255
- Product name
- Diethyl Ethoxymethylenemalonate
- Purity
- >98.0%(GC)
- Packaging
- 100mL
- Price
- $40
- Updated
- 2024/03/01
- Product number
- A13776
- Product name
- Diethyl ethoxymethylenemalonate, 98+%
- Packaging
- 50g
- Price
- $22.65
- Updated
- 2024/03/01
Diethyl ethoxymethylenemalonate Chemical Properties,Usage,Production
Chemical Properties
CLEAR COLOURLESS TO LIGHT YELLOW LIQUID
Uses
Diethyl ethoxymethylenemalonate is used for synthesis of pyrido[3,2-e]pyrimido[1,2-c]pyrimidines. Initially, it was used to monitor lysine decarboxylase activity. It is useful in the determination of amino acids by precolumn derivatization by using reversed-phase high-performance liquid chromatography (HPLC). It plays an important role in the Gould-Jacobs reaction to prepare quinolines. For example, anile reacts with this reagent to give 4-hydroxyquinoline. It acts as an intermediate in the production of flumequine, which is a fluoroquinolone antibiotic.
Safety Profile
Moderately toxic by ingestion. A skin irritant. A combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes.
Purification Methods
Likely impurity is diethyl diethoxymethylene malonate which is difficult to separate from diethyl ethoxymethylene malonate by distillation, and it is necessary to follow the course of the distillation by the change in refractive index instead of boiling point. After a low boiling fraction is collected, there is obtained an intermediate fraction (n 20 1.414—1.458), the size of which depends on the amount of the diethoxymethylene compound. This fraction is fractionated through a 5inch Vigreux column (p 11) at low pressure avoiding interruption in heating. Fraction b 108-110o/0.25mm is ca 10o lower than the submitters' fraction (b 97.2o/0.25mm, n D 1.4612—1.4623) [Org Synth Coll Vol III 395 1955, Fuson et al. J Org Chem 11 197 1946, Duff & Kendal J Chem Soc 893 1948]. [Beilstein 3 IV 1192.]
Diethyl ethoxymethylenemalonate Preparation Products And Raw materials
Raw materials
Preparation Products
Diethyl ethoxymethylenemalonate Suppliers
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View Lastest Price from Diethyl ethoxymethylenemalonate manufacturers
- Product
- Diethyl ethoxymethylenemalonate 87-13-8
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-05-11
- Product
- Diethyl ethoxymethylenemalonate 87-13-8
- Price
- US $50.00-8.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-09-06
- Product
- Diethyl ethoxymethylenemalonate 87-13-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2022-10-20