3-Bromo-5-fluorobenzonitrile
- Product Name
- 3-Bromo-5-fluorobenzonitrile
- CAS No.
- 179898-34-1
- Chemical Name
- 3-Bromo-5-fluorobenzonitrile
- Synonyms
- 3-BROMO-5-FLUOROBENZONITRILE;3-Cyano-5-fluorobromobenzene;3-BroMo-5-fluoronitrobenzene;3-Bromo-5-fluorobenzonitrole;Benzonitrile, 3-bromo-5-fluoro-;3-Bromo-5-fluorobenzonitrile98%;3-Bromo-5-fluorobenzonitrile 98%;-Bromo-5-fluorobenzonitrile 98%
- CBNumber
- CB3184567
- Molecular Formula
- C7H3BrFN
- Formula Weight
- 200.01
- MOL File
- 179898-34-1.mol
3-Bromo-5-fluorobenzonitrile Property
- Melting point:
- 43 °C
- Boiling point:
- 218.7±20.0 °C(Predicted)
- Density
- 1.69±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to lump
- color
- White to Almost white
- CAS DataBase Reference
- 179898-34-1(CAS DataBase Reference)
Safety
- Hazard Codes
- T,Xi,Xn
- Risk Statements
- 20/21/22-36/37/38-36-22
- Safety Statements
- 26-36/37/39
- RIDADR
- 3439
- Hazard Note
- Toxic
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- CDS003867
- Product name
- 3-Bromo-5-fluorobenzonitrile
- Purity
- AldrichCPR
- Packaging
- 250mg
- Price
- $61.6
- Updated
- 2023/06/20
- Product number
- B4600
- Product name
- 3-Bromo-5-fluorobenzonitrile
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $16
- Updated
- 2024/03/01
- Product number
- B4600
- Product name
- 3-Bromo-5-fluorobenzonitrile
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $63
- Updated
- 2024/03/01
- Product number
- H26066
- Product name
- 3-Bromo-5-fluorobenzonitrile, 98%
- Packaging
- 1g
- Price
- $20.65
- Updated
- 2024/03/01
- Product number
- H26066
- Product name
- 3-Bromo-5-fluorobenzonitrile, 98%
- Packaging
- 10g
- Price
- $130.65
- Updated
- 2024/03/01
3-Bromo-5-fluorobenzonitrile Chemical Properties,Usage,Production
Chemical Properties
off-white crystalline
Uses
3-Bromo-5-fluorobenzonitrile is a compound of benzonitrile containing bromine and fluorine atoms, which is mainly used as an intermediate component in organic synthesis.
Synthesis
3-Bromo-5-fluorobenzonitrile is synthesised using 1,3-dibromo-5-fluorobenzene as a raw material by chemical reaction. The specific synthesis steps are as follows:
A 250-mL round-bottom flask equipped with a magnetic stir bar was charged with 1,3-dibromo-5-fluorobenzene (7.70 g, 30.3 mmol), DMF (45 mL), pyridine (4.9 mL), and copper (I) cyanide (2.72 g, 30.3 mmol) under nitrogen.
A reflux condenser was attached to the flask.
The green, cloudy mixture was stirred at reflux for 3 h.
Once lower Rf impurities were observed, the reaction was allowed to cool to room temperature.
The reaction was quenched with 30 mL of ether, and a precipitate formed in the dark solution.
The precipitate was gravity-filtered though Celite.
The filtrate was rinsed three times with ether (100 mL/50 g bromide).
The isolated solution was added to a separatory funnel.
The organic layer was washed with a 2:1 mixture of water and concentrated ammonium hydroxide (30 mL), followed by saturated ammonium chloride solution (2*30 mL) and saturated sodium bicarbonate (30 mL).
The aqueous layers were extracted with ether (3*40 mL).
The organic layers were combined and dried over anhydrous sodium sulfate.
The product was purified by flash column chomatography to yield 3-bromo-5-fluorobenzonitrile (2.10 g, 35percent).
1H NMR (400 MHz, CDCl3) δ 7.62 (s, 1H), 7.54-7.50 (m, 1H), 7.35-7.32 (m, 1H).
3-Bromo-5-fluorobenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Bromo-5-fluorobenzonitrile manufacturers
- Product
- 3-Bromo-5-fluorobenzonitrile 179898-34-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-19
- Product
- 3-Bromo-5-fluorobenzonitrile 179898-34-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-07-27
- Product
- 3-Bromo-5-fluorobenzonitrile 179898-34-1
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-15