ChemicalBook > CAS DataBase List > Pheniramine

Pheniramine

Product Name
Pheniramine
CAS No.
86-21-5
Chemical Name
Pheniramine
Synonyms
AVIL;Metron;Pyriton;Trimeton;Tripoton;Feniramine;NCI-C60695;PHENIRAMINE;Propheniramine;PHENIRAMINE BASE
CBNumber
CB3192278
Molecular Formula
C16H20N2
Formula Weight
240.34
MOL File
86-21-5.mol
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Pheniramine Property

Melting point:
<25 °C
Boiling point:
bp13 181°; bp2 142°; bp0.5 135°
Density 
1.0081
refractive index 
nD25 1.5519 to 1.5521
Flash point:
9℃
storage temp. 
-20°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Oil
pka
pKa 4.03± 0.08;9.32± 0.06(H2O,t undefined,I=0.30(NaCl)) (Uncertain)
color 
Colourless
InChIKey
IJHNSHDBIRRJRN-UHFFFAOYSA-N
CAS DataBase Reference
86-21-5(CAS DataBase Reference)
NIST Chemistry Reference
Pyridine, 2[alpha-(2-dimethyl aminoethyl)benzyl](86-21-5)
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Safety

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
16-36/37-45
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P-045
Product name
Pheniramine solution
Purity
1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$41.5
Updated
2024/03/01
TRC
Product number
P297195
Product name
Pheniramine
Packaging
250mg
Price
$835
Updated
2021/12/16
Biorbyt Ltd
Product number
orb531229
Product name
AVIL
Packaging
10μg
Price
$1326
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
16868
Product name
Pheniramine
Packaging
1mg
Price
$525
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009137
Product name
PHENIRAMINE
Purity
95.00%
Packaging
250MG
Price
$727.65
Updated
2021/12/16
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Pheniramine Chemical Properties,Usage,Production

Originator

Trimeton Maleate, Schering ,US,1948

Uses

Pheniramine is an antigripal drug. Also, it is derived from 2-Benzylpyridine (B288740), which is a benzylpyridine with antifungal properties. 2-Benzylpyridine is also used as a chromogenic reagent for micro determination of Molybednum.

Definition

ChEBI: N,N-dimethyl-3-phenyl-3-(2-pyridinyl)-1-propanamine is a tertiary amino compound and a member of pyridines.

Manufacturing Process

According to US Patent 2,676,964: to 1.0 mol of potassium amide in 3 liters of liquid ammonia, is added 1.0 mol of 2-benzylpyridine. After 15 minutes, 1.1 mols of β-dimethylaminoethyl chloride are added. The ammonia is allowed to evaporate and the reaction product decomposed with water and ether extracted. The ether layer is dried over sodium sulfate and after evaporation the residue is distilled, giving the 3-phenyl-3-(2-pyridyl)-N,Ndimethylpropylamine, BP 139°-142°C/1-2 mm. The maleate is produced by reaction with maleic acid.

Therapeutic Function

Antihistaminic

Synthesis Reference(s)

The Journal of Organic Chemistry, 59, p. 7125, 1994 DOI: 10.1021/jo00102a044

Safety Profile

Poison by intravenous route. Human systemic effects by ingestion: central nervous system effects. When heated to decomposition it emits toxic fumes of NOx.

Enzyme inhibitor

This antihistamine (FWfree-base = 240.35 g/mol; CAS 86-21-5; insoluble in water; maleate and p-aminosalicylate salts are water-soluble), also known as N,N-dimethyl-g-phenyl-2-pyridinepropanamide, is more frequently abused than other antihistamines relative to its market share. One of the histamine H1 antagonists with little sedative action, pheniramine is often used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus. Target(s): H1 histamine receptor; and histamine Nmethyltransferase, mildly inhibited.

Pheniramine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Pheniramine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Pheniramine 86-21-5
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-08
Career Henan Chemical Co
Product
Pheniramine 86-21-5
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 486
Release date
2019-09-01

86-21-5, PheniramineRelated Search:

Dimethyl carbonate Pyridine ETHANE 3-Dimethylaminopropylamine 2,6-Lutidine Dimethyl fumarate Chlorodimethylphenylsilane PHENYL VALERATE Dimethyl ether Dimethyl sulfoxide N,N-Dimethylformamide N,N-Dimethyldodecylamine (R)-(-)-1-Methyl-3-phenylpropylamine CHLORODIMETHYLVINYLSILANE Dimethyl sulfate Propylamine DIMETHYLAMINOPYRIDINE, POLYMER-BOUND PHENIRAMINE MALEATE,PHENIRAMINE MALEATE SALT

  • n,n-dimethyl-3-phenyl-3-(2-pyridyl)propylamine
  • PHENIRAMINE
  • 2-(alpha-(2-(dimethylamino)ethyl)benzyl)-pyridin
  • 2-[(S)-α-[2-(Dimethylamino)ethyl]benzyl]pyridine
  • 2-[α-(2-Dimethylaminoethyl)benzyl]pyridine
  • Pheniramine solution
  • N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine
  • Dexchlorpheniramine EP Impurity A
  • Dexchlorpheniramine Maleate EP Impurity A
  • dimethyl(3-phenyl-3-(2-pyridyl)propyl)amine
  • PHENIRAMINE BASE
  • Pheniramine (base and/or unspecified salts)
  • (-)-2-[(R)-α-[2-(Dimethylamino)ethyl]benzyl]pyridine
  • (R)-1-(Dimethylamino)-3-phenyl-3-(2-pyridinyl)propane
  • 2-[(R)-α-[2-(Dimethylamino)ethyl]benzyl]pyridine
  • (+)-2-[(S)-α-[2-(Dimethylamino)ethyl]benzyl]pyridine
  • (S)-1-(Dimethylamino)-3-phenyl-3-(2-pyridinyl)propane
  • 2-(alpha-(2-dimethylaminoethyl)benzyl)pyridine
  • 2-[alpha-[2-(Dimethylamino)ethyl]benzyl]pyridine
  • 2-Pyridinepropanamine, N,N-dimethyl-gamma-phenyl-
  • 3-Phenyl-3-(2-pyridyl)-N,N-dimethylpropylamine
  • 3-phenyl-3-(2-pyridyl)-n,n-dimethylpropylanine
  • AVIL
  • Feniramine
  • Metron
  • N,N-Dimethyl-3-phenyl-3-(2-pyridinyl)-1-propanamine
  • n,n-dimethyl-gamma-phenyl-2-pyridinepropanamin
  • NCI-C60695
  • Propheniramine
  • Prophenpyridamine
  • Pyridine, 2-[alpha-[2-(dimethylamino)ethyl]benzyl]-
  • Pyriton
  • Trimeton
  • Tripoton
  • 1-phenyl-1-(2-pyridyl)-3-dimethylaminopropane
  • 2-(3-dimethylamino-1-phenylpropyl)pyridine
  • 2-Pyridinepropanamine, N,N-dimethyl-γ-phenyl-
  • Pheniramine USP/EP/BP
  • Brompheniramine maleate EP Impurity C
  • (3RS)-N,N-dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine
  • Chlorpheniramine Impurity 13（Dexchlorpheniramine EP Impurity A）
  • Brompheniramine Maleate Impurity C
  • Brompheniramine EP Impurity C
  • (±)-Pheniramine in methanol
  • Dexchlorpheniramine EP Impurity
  • Dexlobenamine EP Impurity A
  • Rapamycin Impurity 34
  • 86-21-5