Pheniramine
- Product Name
- Pheniramine
- CAS No.
- 86-21-5
- Chemical Name
- Pheniramine
- Synonyms
- AVIL;Metron;Pyriton;Trimeton;Tripoton;Feniramine;NCI-C60695;PHENIRAMINE;Propheniramine;PHENIRAMINE BASE
- CBNumber
- CB3192278
- Molecular Formula
- C16H20N2
- Formula Weight
- 240.34
- MOL File
- 86-21-5.mol
Pheniramine Property
- Melting point:
- <25 °C
- Boiling point:
- bp13 181°; bp2 142°; bp0.5 135°
- Density
- 1.0081
- refractive index
- nD25 1.5519 to 1.5521
- Flash point:
- 9℃
- storage temp.
- -20°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Oil
- pka
- pKa 4.03± 0.08;9.32± 0.06(H2O,t undefined,I=0.30(NaCl)) (Uncertain)
- color
- Colourless
- InChIKey
- IJHNSHDBIRRJRN-UHFFFAOYSA-N
- CAS DataBase Reference
- 86-21-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Pyridine, 2[alpha-(2-dimethyl aminoethyl)benzyl](86-21-5)
Safety
- Hazard Codes
- F,T
- Risk Statements
- 11-23/24/25-39/23/24/25
- Safety Statements
- 16-36/37-45
- RIDADR
- UN1230 - class 3 - PG 2 - Methanol, solution
- WGK Germany
- 1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H370Causes damage to organs
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P311Call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- P-045
- Product name
- Pheniramine solution
- Purity
- 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
- Packaging
- 1mL
- Price
- $41.5
- Updated
- 2024/03/01
- Product number
- P297195
- Product name
- Pheniramine
- Packaging
- 250mg
- Price
- $835
- Updated
- 2021/12/16
- Product number
- orb531229
- Product name
- AVIL
- Packaging
- 10μg
- Price
- $1326
- Updated
- 2021/12/16
- Product number
- 16868
- Product name
- Pheniramine
- Packaging
- 1mg
- Price
- $525
- Updated
- 2021/12/16
- Product number
- API0009137
- Product name
- PHENIRAMINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $727.65
- Updated
- 2021/12/16
Pheniramine Chemical Properties,Usage,Production
Originator
Trimeton Maleate, Schering ,US,1948
Uses
Pheniramine is an antigripal drug. Also, it is derived from 2-Benzylpyridine (B288740), which is a benzylpyridine with antifungal properties. 2-Benzylpyridine is also used as a chromogenic reagent for micro determination of Molybednum.
Definition
ChEBI: N,N-dimethyl-3-phenyl-3-(2-pyridinyl)-1-propanamine is a tertiary amino compound and a member of pyridines.
Manufacturing Process
According to US Patent 2,676,964: to 1.0 mol of potassium amide in 3 liters of liquid ammonia, is added 1.0 mol of 2-benzylpyridine. After 15 minutes, 1.1 mols of β-dimethylaminoethyl chloride are added. The ammonia is allowed to evaporate and the reaction product decomposed with water and ether extracted. The ether layer is dried over sodium sulfate and after evaporation the residue is distilled, giving the 3-phenyl-3-(2-pyridyl)-N,Ndimethylpropylamine, BP 139°-142°C/1-2 mm. The maleate is produced by reaction with maleic acid.
Therapeutic Function
Antihistaminic
Synthesis Reference(s)
The Journal of Organic Chemistry, 59, p. 7125, 1994 DOI: 10.1021/jo00102a044
Safety Profile
Poison by intravenous route. Human systemic effects by ingestion: central nervous system effects. When heated to decomposition it emits toxic fumes of NOx.
Enzyme inhibitor
This antihistamine (FWfree-base = 240.35 g/mol; CAS 86-21-5; insoluble in water; maleate and p-aminosalicylate salts are water-soluble), also known as N,N-dimethyl-g-phenyl-2-pyridinepropanamide, is more frequently abused than other antihistamines relative to its market share. One of the histamine H1 antagonists with little sedative action, pheniramine is often used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus. Target(s): H1 histamine receptor; and histamine Nmethyltransferase, mildly inhibited.
Pheniramine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Pheniramine manufacturers
- Product
- Pheniramine 86-21-5
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-08
- Product
- Pheniramine 86-21-5
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- JD 486
- Release date
- 2019-09-01