Description
ChemicalBook > CAS DataBase List > 2-Chloro-2',4'-difluoroacetophenone

2-Chloro-2',4'-difluoroacetophenone

Description
Product Name
2-Chloro-2',4'-difluoroacetophenone
CAS No.
51336-94-8
Chemical Name
2-Chloro-2',4'-difluoroacetophenone
Synonyms
2-CHLORO-1-(2,4-DIFLUOROPHENYL)ETHANONE;2,4-difluorophenacyl chloride ,2-chloro-1-(2,4-difluorophenyl)ethanone;2-Chloro-2;Voriconazole RC1;TIMTEC-BB SBB006665;Voriconazole Impurity 6;2,4-DIFLUOROPHENACYL CHLORIDE;2,4-Difluorophenacylchloride98%;2,4-Difluorophenacyl chloride 98%;2'-Chloro 2,4-fluoro acetophenone
CBNumber
CB3205231
Molecular Formula
C8H5ClF2O
Formula Weight
190.57
MOL File
51336-94-8.mol
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2-Chloro-2',4'-difluoroacetophenone Property

Melting point:
44-48 °C(lit.)
Boiling point:
240.9±25.0 °C(Predicted)
Density 
1.3544 (estimate)
Flash point:
>230 °F
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly)
form 
Solid
color 
Light Brown
Sensitive 
Lachrymatory
BRN 
1943217
InChI
InChI=1S/C8H5ClF2O/c9-4-8(12)6-2-1-5(10)3-7(6)11/h1-3H,4H2
InChIKey
UENGBOCGGKLVJJ-UHFFFAOYSA-N
SMILES
C(=O)(C1=CC=C(F)C=C1F)CCl
CAS DataBase Reference
51336-94-8(CAS DataBase Reference)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
34-37
Safety Statements 
26-36/37/39-45-25-27
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
F 
10-21
Hazard Note 
Corrosive/Irritant/Lachrymatory
HazardClass 
8
PackingGroup 
II
HS Code 
29147000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H330Fatal if inhaled

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
272507
Product name
2-Chloro-2′,4′-difluoroacetophenone
Purity
98%
Packaging
5g
Price
$130
Updated
2023/06/20
Sigma-Aldrich
Product number
272507
Product name
2-Chloro-2′,4′-difluoroacetophenone
Purity
98%
Packaging
25g
Price
$135
Updated
2023/01/07
TCI Chemical
Product number
C2030
Product name
2-Chloro-2',4'-difluoroacetophenone
Purity
>98.0%(GC)
Packaging
5g
Price
$37
Updated
2025/07/31
TCI Chemical
Product number
C2030
Product name
2-Chloro-2',4'-difluoroacetophenone
Purity
>98.0%(GC)
Packaging
25g
Price
$109
Updated
2025/07/31
TRC
Product number
C365670
Product name
2-Chloro-2'',4''-difluoroacetophenone
Packaging
25g
Price
$200
Updated
2021/12/16
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2-Chloro-2',4'-difluoroacetophenone Chemical Properties,Usage,Production

Description

2-Chloro-2′,4′-difluoroacetophenone was used in the synthesis of allyl alcohol1. It can also be tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B2.

Chemical Properties

white crystalline powder

Uses

2-Chloro-2′,4′-difluoroacetophenone was used in the synthesis of allyl alcohol.

Uses

A α-haloacetophenone derivatives tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B.

Synthesis

372-18-9

79-04-9

51336-94-8

In a 250 mL four-necked flask equipped with a thermometer, a constant pressure dropping funnel, and a reflux condenser (with a drying tube), 1,3-difluorobenzene (0.1 mol, 14.7 g) and anhydrous aluminum trichloride (0.17 mol, 22.7 g) were added. The mixture was stirred at 30-35°C for 0.5 hours. Subsequently, chloroacetyl chloride (0.12 mol, 13.56 g) was slowly added dropwise to maintain the reaction temperature. After the dropwise addition was completed, the temperature was raised to 50-55 °C and the reaction was continued with stirring until no hydrogen chloride gas escaped, a reaction time of about 5 hours. The reaction mixture was cooled to below 5°C in an ice-water bath, and acid hydrolysis was carried out by slowly dropping 3 mol/L hydrochloric acid (20 mL), controlling the rate of dropwise acceleration to keep the temperature of the mixture low. The acid-hydrolyzed mixture was poured into a beaker and distilled water was added to precipitate the solid. After filtration and drying under reduced pressure, 16.9 g of light yellow powdery solid was obtained in 89.3% yield. Finally, the light yellow powdery solid was recrystallized with hexane to give bright yellow crystalline 2'-chloro-2,4-difluoroacetophenone.

References

[1] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003, vol. 42, # 2, p. 372 - 381
[2] Tetrahedron Asymmetry, 2010, vol. 21, # 13-14, p. 1649 - 1665
[3] Patent: CN106187924, 2016, A. Location in patent: Paragraph 0026; 0027
[4] Patent: CN102796080, 2016, B. Location in patent: Paragraph 0040-0042
[5] Journal of Organic Chemistry, 1995, vol. 60, # 10, p. 3000 - 3012

2-Chloro-2',4'-difluoroacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-2',4'-difluoroacetophenone Suppliers

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View Lastest Price from 2-Chloro-2',4'-difluoroacetophenone manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
2-Chloro-1-(2,4-difluorophenyl)ethanone 51336-94-8
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-11-25
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Chloro-2',4'-difluoroacetophenone 51336-94-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-19
Career Henan Chemical Co
Product
BOC-D-2-TRIFLUOROMETHYLPHENYLALANINE 51336-94-8
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-08-26

51336-94-8, 2-Chloro-2',4'-difluoroacetophenone Related Search:

4'-Bromoacetophenone 3'-Chloroacetophenone 3'-Fluoroacetophenone 1-(2,6-Difluorophenyl)ethan-1-one 2',4'-Difluoroacetophenone 4-Nitroacetophenone 3-Nitroacetophenone 4-Fluoroacetophenone 2-Chloroacetophenone 4'-Hydroxyacetophenone Trifluoroacetophenone 2',4'-Dichloroacetophenone 4'-(Trifluoromethyl)acetophenone Acetophenone 2'-Chloroacetophenone 6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine Voriconazole Impurity 53 Voriconazole

  • 2,4-difluorophenacyl chloride ,2-chloro-1-(2,4-difluorophenyl)ethanone
  • Chloromethyl(2,4-difluorophenyl) ketone
  • 2-CHLORO-2',4'-DIFLUOROACETOPHEONE
  • 2-Bhloro-2',4'-difluoroacetophenone
  • Ethanone,2-chloro-1-(2,4-difluorophenyl)-
  • 2-Chloro-2',4'-difluoroacetophenone,98%
  • 2-Chloro-2
  • [2-(2,4-difluorophenyl)-2-oxoethyl]chloranuide
  • 2-Chloro-2',4'-difluoroacetophenone, 2-Chloro-1-(2,4-difluorophenyl)ethan-1-one
  • Voriconazole Impurity 6(RR,SS mixture)
  • Fluconazole Impurity 6 (2-Chloro-2’,4’-Difluoroacetophenone)
  • 2-Chloro-2',4'-difluoroacetophenone benzenamine
  • 2-Chloro-2',4'-difluoroacetophenone, 97+%
  • 2-Chloro-2',4'-difluoroacetophenone 98%
  • Voriconazole Impurity 6
  • 2-CHLORO-1-(2,4-DIFLUOROPHENYL)ETHANONE
  • 2'-CHLORO-2,4-DIFLUOROACETOPHENONE
  • 2',4'-DIFLUORO-2-CHLOROACETOPHENONE
  • 2',4'-DIFLUORO-ALPHA-CHLOROACETOPHENONE
  • 2',4'-DIFLUORO-ALFA-CHLOROACETOPHENONE
  • 2,4-DIFLUOROPHENACYL CHLORIDE
  • ALPHA-CHLORO-2,4-DIFLUOROACETOPHENONE
  • TIMTEC-BB SBB006665
  • 2,4-Difluorophenacyl chloride 98%
  • 2,4-Difluorophenacylchloride98%
  • 2'-Chloro 2,4-fluoro acetophenone
  • 2-Chloro-2,4-Difluoroacetophenone/2,4-Difluoro-2-Chloro-Acetophenone
  • 2',4'-Diflouro-2-Chloroacetophenone
  • a-Chloroacetyl-2,4-Difluorobenzene
  • α -Chloro-2,4-Difluoroacetophenone
  • 2,4-difluoro-α-chloroacetophenone
  • 2-Chloro-2',4'-difluoroacetophenone &gt
  • Voriconazole RC1
  • 2-chloro-1-(2,4-difluorophenyl)ethanone(51336-94-8)
  • 2,4Difluoro 1H,1yl,1,2,4Triazole Acetophenone (DFTA)
  • 2-Chloro-2',4'-difluoroacetophenone
  • 2',4'-DIFLUORO-2-CHLORO ACETOPHENONE (CL- COMPOUND OF DFTA IMPURITY)
  • 51336-94-8
  • 632-42-2
  • C8H5OClF2
  • F2C6H3COCH2Cl
  • Organic Building Blocks
  • Ketones
  • C7 to C8
  • Carbonyl Compounds
  • Building Blocks
  • Acetophenone series
  • Aromatics
  • Inhibitors
  • C7 to C8
  • Carbonyl Compounds
  • Ketones
  • blocks
  • FluoroCompounds
  • Benzene series