ChemicalBook > CAS DataBase List > 4-Hydroxymethyl-4-methylpiperidine

4-Hydroxymethyl-4-methylpiperidine

Product Name
4-Hydroxymethyl-4-methylpiperidine
CAS No.
297172-16-8
Chemical Name
4-Hydroxymethyl-4-methylpiperidine
Synonyms
4-HydroxyMethyl-4-Methylp...;4-methyl-4-Piperidinemethanol;(4-methyl-4-piperidyl)methanol;4-Piperidinemethanol, 4-methyl-;(4-Methylpiperidin-4-yl)methanol;4-Hydroxymethyl-4-methylpiperidine;(4-Methylpiperidin-4-yl)methanol hcl;(4-Methylpiperidin-4-yl)Methanol hydrochloride;(4-methyl-4-piperidinyl)methanol(SALTDATA: HCl)
CBNumber
CB32105823
Molecular Formula
C7H15NO
Formula Weight
129.2
MOL File
297172-16-8.mol
More
Less

4-Hydroxymethyl-4-methylpiperidine Property

Boiling point:
200.8±13.0℃ (760 Torr)
Density 
0.926±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:
76.7±10.5℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
14.94±0.10(Predicted)
More
Less

Safety

HS Code 
2933399990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
M725943
Product name
(4-Methylpiperidin-4-yl)methanol
Packaging
10mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
Z4573
Product name
(4-Methylpiperidin-4-yl)methanol
Packaging
250mg
Price
$105
Updated
2021/12/16
Apolloscientific
Product number
OR907789
Product name
(4-Methylpiperidin-4-yl)methanol
Purity
95%
Packaging
250mg
Price
$120
Updated
2021/12/16
AK Scientific
Product number
Z4573
Product name
(4-Methylpiperidin-4-yl)methanol
Packaging
1g
Price
$189
Updated
2021/12/16
Apolloscientific
Product number
OR907789
Product name
(4-Methylpiperidin-4-yl)methanol
Purity
95%
Packaging
1g
Price
$200
Updated
2021/12/16
More
Less

4-Hydroxymethyl-4-methylpiperidine Chemical Properties,Usage,Production

Synthesis

878167-03-4

297172-16-8

Step 3: Synthesis of 4-(hydroxymethyl)-4-methylpiperidine To a solution of (1-benzyl-4-methylpiperidin-4-yl) methanol (2.7 g, 12 mmol) in methanol (34 mL) was sequentially added ammonium formate (8.6 g) and 10% palladium carbon catalyst (3.6 g, 1.7 mmol). The reaction mixture was stirred for 18 hours under a hydrogen balloon atmosphere. Upon completion of the reaction, the mixture was degassed, flushed with nitrogen and filtered through a diatomaceous earth pad to remove the catalyst. Subsequently, the solvent was evaporated under reduced pressure and the resulting crude product was purified by fast chromatography (silica gel, 40 g, ISCO system, eluent: 0-20% methanol gradient in dichloromethane) to afford 4-(hydroxymethyl)-4-methylpiperidine as a colorless oil, which was used directly in the next step of the reaction. After further purification, 1.2 g of the target product was obtained in 76% yield.

References

[1] Patent: WO2011/73263, 2011, A1. Location in patent: Page/Page column 147
[2] Patent: WO2006/23852, 2006, A2. Location in patent: Page/Page column 82-84
[3] Patent: WO2006/58303, 2006, A2. Location in patent: Page/Page column 69
[4] Patent: US2008/15179, 2008, A1. Location in patent: Page/Page column 120
[5] Patent: WO2007/100670, 2007, A1. Location in patent: Page/Page column 45-46

4-Hydroxymethyl-4-methylpiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-Hydroxymethyl-4-methylpiperidine Suppliers

China 65 Germany 1 India 1 United Kingdom 1 United States 9 Global 77
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembon Pharmaceutical Co., Ltd.
Tel
028-84252981
Fax
+86-28-84252965
Email
sales@chembon.com.cn
Country
China
ProdList
850
Advantage
64
skychemical Co.Ltd
Tel
021-20958197 20965099
Fax
021-20960837
Email
sales@skychemical.com
Country
China
ProdList
1183
Advantage
57
Atop-Pharma (Shanghai) Technology Co., Ltd.
Tel
+86 (21) 5196-9732
Fax
+86 (21) 5196-9733
Country
China
ProdList
996
Advantage
57
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
Chengdu Forest Science and Technology Development Co., Ltd.
Tel
18030648795
Fax
028-61777050
Email
sales@cdforestchem.com
Country
China
ProdList
2000
Advantage
58
Kohn & Shawn Pharmatech Co.,Ltd
Tel
0931-4190454 13893344397
Fax
+86-931-8506154
Email
sales@kyxpharma.com
Country
China
ProdList
310
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
SynAsst Chemical.
Tel
021-60343070
Fax
021-35122006
Country
China
ProdList
12740
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
PingHeAnKang Pharmaceutical Co., Ltd.
Tel
18086832706
Fax
028-89642128
Email
phakzjtxs@phak.cn
Country
China
ProdList
138
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15873
Advantage
55
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
skychemical Co.Ltd
Tel
021-20960837,QQ1332204249
Fax
021-20960837
Email
sales@skychemical.com
Country
China
ProdList
3341
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Cck Pharmchem Co.,Ltd
Tel
0512-68131995 13862051930
Fax
0512-68131995
Country
China
ProdList
360
Advantage
55
Shanghai Huaxing Biological Technology Co., Ltd.
Tel
18621295758
Fax
-QQ:1449085402
Email
1449085402@qq.com
Country
China
ProdList
1978
Advantage
55
Nanjing KaiMubo Pharmaceutical Co., Ltd.
Tel
025-66162170
Fax
025-66162170
Country
China
ProdList
7181
Advantage
55
Adobe Chem Co., Ltd.
Tel
2332782371
Fax
QQ: 2332782371
Email
adobechem@qq.com
Country
China
ProdList
7980
Advantage
58
Chengdu Saiousi Pharmaceutical Co., Ltd
Tel
028-64971018 18108168130
Fax
86 028-64971018
Country
China
ProdList
1781
Advantage
55
Hangzhou Molcore Biopharmatech Co.,Ltd
Tel
400-711-5280 86-571-81025280
Fax
86-571-85806285
Email
sales@molcore.com
Country
China
ProdList
9967
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
16027
Advantage
58
Nanjing SynTitan Pharmaceutical Co., Ltd.
Tel
025-57027686 17372956142
Fax
025-57027686
Email
li_lan@syntitan.com
Country
China
ProdList
9998
Advantage
58
Zhengzhou Ruke Biological Co., Ltd.
Tel
15981811963
Fax
QQ：1410472904
Email
1410472904@qq.com
Country
China
ProdList
5825
Advantage
58
Chengdu AiQun Pharmaceutical Technology Co., Ltd.
Tel
028-82393420 18108156287
Fax
028-82393420
Email
2982653826@qq.com
Country
China
ProdList
560
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Chengdu Forest Science and Technology Development Co,. Ltd
Tel
028-87925786 18010564218
Fax
028-61777050
Email
vendi@cdforestchem.com
Country
China
ProdList
1992
Advantage
58
Lanzhou Kangyuxin Biotechnology Co., Ltd.
Tel
0931-4190454 13893344397
Email
sales@kyxpharma.com
Country
China
ProdList
3151
Advantage
58
Shanghai zhigan biotechnology co., LTD
Tel
Email
zhiqianbio@126.com
Country
China
ProdList
19778
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-55055611 18137792234
Fax
QQ：3002694073
Email
3002694073@qq.com
Country
China
ProdList
9987
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
Nanjing Hengbei Chemicals Co., Ltd.
Tel
+86-25-58393656
Fax
+86-25-58393656
Email
sales@hengbeichem.cn
Country
China
ProdList
6854
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25356
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-0571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52846
Advantage
58
Hefei Hirisun Pharmatech Co., Ltd
Tel
+8615056975894
Fax
86-0551-62678551
Email
shawn@hirisunpharm.com
Country
CHINA
ProdList
9911
Advantage
58
Amel Pharmatech Corporation
Tel
027-888-4366503
Fax
888-502-1736
Email
sales@amelpharmatech.com
Country
China
ProdList
5000
Advantage
58
Zhejiang Lianshuo Biotechnology Co., Ltd.
Tel
18616526224
Email
lianshuo@vip.126.com
Country
China
ProdList
9607
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29798
Advantage
58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
Tel
+8613580539051
Email
joe@yuhengpharm.com
Country
CHINA
ProdList
21142
Advantage
58
Advanced chemblocks inc
Tel
650-6922368
Email
sales@achemblock.com
Country
China
ProdList
2992
Advantage
58
JW & Y Pharmlab Co., Ltd.
Tel
021-64340559 13651849907
Fax
021-64345308
Email
xinyu_shi@jwypharmlab.com.cn
Country
China
ProdList
9381
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44119
Advantage
58
TCI (Shanghai) Chemical Trading Co., Ltd.
Tel
021-61109150
Fax
021-61105897
Email
sales@tcisct.com
Country
China
ProdList
29668
Advantage
58
Zhengzhou Akem Chemical Co., Ltd
Tel
13303867194
Email
3001317055@qq.com
Country
China
ProdList
9680
Advantage
58
Bide Pharmatech Ltd.
Tel
400-6005915
Email
sales@picasso-e.com
Country
China
ProdList
39653
Advantage
58
Jiaxing Zhejia Biotechnology Co., LTD
Tel
0573-85609002 18367600069;
Email
zhejia01@163.com
Country
China
ProdList
8887
Advantage
58
Changzhou Wanyao Biotechnology Co., Ltd.
Tel
051989185693 15312551983
Email
2410037592@qq.com
Country
China
ProdList
1201
Advantage
58
Shanghai Haohong Scientific Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
https://hanhongsci.com/
Tel
021-54306202 18917919676
Email
info@hanhongsci.com
Country
China
ProdList
29995
Advantage
58
More
Less

View Lastest Price from 4-Hydroxymethyl-4-methylpiperidine manufacturers

Career Henan Chemical Co
Product
4-Hydroxymethyl-4-methylpiperidine 297172-16-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KGS
Release date
2020-01-08

297172-16-8, 4-Hydroxymethyl-4-methylpiperidineRelated Search:

Naloxone hydrochloride MEPERIDINE THEBAINE NORMORPHINE MEPERIDINE HYDROCHLORIDE MORPHINIUM CHLORIDE Naltrexone hydrochloride 4-PHENYL-4-PIPERIDINECARBOXYLIC ACID 4-METHYL-BENZENESULFONATE NALORPHINE HYDROCHLORIDE NORCODEINE DIPHENOXYLATE HYDROCHLORIDE NALOXONAZINE DIHYDROCHLORIDE M-6-G TRIFLUOROACETATE-HYDRATE NALTRINDOLE HYDROCHLORIDE M-3-G HYDRATE 4-phenyl-1-(p-tolylsulphonyl)piperidine-4-carboxylic acid BETA-FUNALTREXAMINE HYDROCHLORIDE NOROXYMORPHONE

  • 4-Hydroxymethyl-4-methylpiperidine
  • (4-Methylpiperidin-4-yl)methanol
  • (4-methyl-4-piperidinyl)methanol(SALTDATA: HCl)
  • 4-HydroxyMethyl-4-Methylp...
  • (4-Methylpiperidin-4-yl)Methanol hydrochloride
  • (4-Methylpiperidin-4-yl)methanol hcl
  • 4-Piperidinemethanol, 4-methyl-
  • 4-methyl-4-Piperidinemethanol
  • (4-methyl-4-piperidyl)methanol
  • 297172-16-8