ChemicalBook > CAS DataBase List > 1-Methyl-1H-pyrazol-5-ylamine

1-Methyl-1H-pyrazol-5-ylamine

Product Name
1-Methyl-1H-pyrazol-5-ylamine
CAS No.
1192-21-8
Chemical Name
1-Methyl-1H-pyrazol-5-ylamine
Synonyms
1-METHYL-1H-PYRAZOL-5-AMINE;2-METHYLPYRAZOL-3-AMINE;-5-amine;NSC 76510;AKOS B024266;AKOS PAO-0256;BUTTPARK 18\09-58;ART-CHEM-BB B024266;1-METHYL-5-AMINOPYRAZOLE;5-AMINO-1-METHYLPYRAZOLE
CBNumber
CB3212622
Molecular Formula
C4H7N3
Formula Weight
97.12
MOL File
1192-21-8.mol
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1-Methyl-1H-pyrazol-5-ylamine Property

Melting point:
73 °C
Boiling point:
95-96°C (0.5 mmHg)
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Solid
pka
4.16±0.10(Predicted)
color 
Dark Red to Orange to Brown
InChI
InChI=1S/C4H7N3/c1-7-4(5)2-3-6-7/h2-3H,5H2,1H3
InChIKey
JESRNIJXVIFVOV-UHFFFAOYSA-N
SMILES
N1(C)C(N)=CC=N1
CAS DataBase Reference
1192-21-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38-22
Safety Statements 
26-36/37/39
RIDADR 
2811
HazardClass 
IRRITANT
HS Code 
29331990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A3303
Product name
5-Amino-1-methylpyrazole
Packaging
5G
Price
$59
Updated
2025/07/31
TCI Chemical
Product number
A3303
Product name
5-Amino-1-methylpyrazole
Packaging
25G
Price
$234
Updated
2025/07/31
TRC
Product number
A617475
Product name
5-Amino-1-methylpyrazole
Packaging
25g
Price
$180
Updated
2021/12/16
Usbiological
Product number
A1379-02
Product name
5-Amino-1-methylpyrazole
Packaging
2.5g
Price
$340
Updated
2021/12/16
TRC
Product number
A617475
Product name
5-Amino-1-methylpyrazole
Packaging
250g
Price
$835
Updated
2021/12/16
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1-Methyl-1H-pyrazol-5-ylamine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

An interesting synthetic intermediate

Synthesis

60838-50-8

60-34-4

1192-21-8

General procedure for the synthesis of 1-methyl-5-aminopyrazole (9) from 3-methoxyacrylonitrile (1a) and methylhydrazine (2b): methylhydrazine (2b) (0.25 mL, 4.7 mmol) and 3-methoxyacrylonitrile (1a) (0.20 mL, 2.4 mmol) were dissolved in toluene/acetic acid (4:1 v/v; 5 mL) solvent mixture. The reaction mixture was placed in a sealed pressure rated Pyrex tube (10 mL) and microwave irradiated for 1 h at 120 °C using a CEM Discover microwave synthesizer set at an initial power of 100 W. The reaction was carried out using a CEM Discover microwave synthesizer. After completion of the reaction, the reaction mixture was cooled in a stream of compressed air. Subsequently, the reaction mixture was neutralized with saturated aqueous NaHCO3 solution and extracted with EtOAc (3 × 20 mL). The organic layers were combined, washed sequentially with water and brine, dried over MgSO4, and the solvent was evaporated in vacuum to afford 1-methyl-5-aminopyrazole (0.22 g, 97%) as a light brown solid with a melting point of 71-73 °C (literature value: 71-72 °C). The product was confirmed by high-resolution mass spectrometry (measured value: 97.0640, C4H7N3 [M] theoretical value: 97.0637).1H NMR (400 MHz; DMSO-d6) δ 7.60 (1H, d, J = 2.0 Hz, H-3), 5.15 (1H, d, J = 2.0 Hz, H-4), 3.85 (2H, br s, with D2O exchange, NH2), 3.50 (3H, s, Me); 13C NMR (126 MHz; DMSO-d6) δ 145.6 (C), 138.5 (CH), 90.8 (CH), 34.0 (Me); LRMS (APcI) m/z (relative intensity) 97 (M+, 100).

References

[1] Tetrahedron, 2013, vol. 69, # 39, p. 8429 - 8438

1-Methyl-1H-pyrazol-5-ylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Methyl-1H-pyrazol-5-ylamine Suppliers

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View Lastest Price from 1-Methyl-1H-pyrazol-5-ylamine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
1-Methyl-1H-pyrazol-5-ylamine 1192-21-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-Methyl-1H-pyrazol-5-ylamine 1192-21-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
1-Methyl-1H-pyrazol-5-ylamine 1192-21-8
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-12-31

1192-21-8, 1-Methyl-1H-pyrazol-5-ylamineRelated Search:

5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE 5-AMINO-4-CYANO-3-CYANOMETHYL-1-PHENYLPYRAZOLE 5-AMINO-1-PHENYLPYRAZOLE-4-CARBONITRILE 5-AMINO-4-CYANO-1-(2-HYDROXYETHYL)PYRAZOLE 1,3-Dimethyl-1H-pyrazol-5-amine 1,4,6-Trimethyl-1H-pyrazolo[3,4-b]pyridin-3-ylamine ,97% 5-Amino-3-methyl-1-phenylpyrazole 5-AMINO-1-PHENYLPYRAZOLE 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE ETHYL 5-AMINO-1-METHYLPYRAZOLE-4-CARBOXYLATE 5-AMINO-1-PHENYLPYRAZOLE-4-CARBOXAMIDE 5-AMINO-3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 1-METHYL-1H-PYRAZOL-4-YLAMINE 1-METHYL-1H-PYRAZOL-3-YLAMINE 3-Amino-5-methylpyrazole 6-Methyl-1H-pyrazolo[3,4-b]pyridin-3-amine 1-(3'-Sulfo)phenyl-3-methyl-5-aminopyrazole 4,6-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDIN-3-AMINE

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  • 1-Methyl-5-amino-1H-pyrazole
  • 5-Amino-1-methyl-1H-pyrazole 97%
  • 1-Methyl-1H-pyrazol-5-amine, 2-Methyl-2H-pyrazol-3-amine
  • NSC 76510
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  • 1H-Pyrazol-5-amine, 1-methyl-
  • 1-METHYL-1H-PYRAZOL-5-AMINE
  • 1-METHYL-1H-PYRAZOL-5-YLAMINE
  • 1-METHYL-5-AMINOPYRAZOLE
  • BUTTPARK 18\09-58
  • ART-CHEM-BB B024266
  • AKOS B024266
  • AKOS PAO-0256
  • 5-AMINO-1-METHYLPYRAZOLE
  • 5-AMINO-1-METHYL-1H-PYRAZOLE
  • 2-METHYL-2 H-PYRAZOL-3-YLAMINE
  • 2-METHYLPYRAZOL-3-AMINE
  • 5-amino-6-hydroxy-1H-pyrimidine-2,4-dione
  • 5-Amino-1-methylpyrazole 97%
  • 1-METHYL-1H-PYRAZOLE-5-YL AMINE
  • -5-amine
  • 1192-21-8
  • C4H7N3
  • Nucleotides and Nucleosides
  • Heterocyclic
  • Nucleotide
  • Amines
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  • Pyrazole series
  • Pyrazole