Benzomorpholine

Product Name: Benzomorpholine
CAS No.: 5735-53-5
Chemical Name: Benzomorpholine
Synonyms: AKOS BC-1149;BENZOMORPHOLINE;AKOS BBS-00002717;CHEMBRDG-BB 4005008;2,3-dihydro-1,4-benzoxazine;3,4-DIHYDRO-2H-1,4-BENZOXAZINE;3,4-Dihydro-2H-benzo[1,4]oxazine;2H-1,4-Benzoxazine, 3,4-dihydro-;3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE;3,4-Dihydro-2H-1,4-benzoxazine, 97+%
CBNumber: CB3231131
Molecular Formula: C8H9NO
Formula Weight: 135.16
MOL File: 5735-53-5.mol

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Benzomorpholine Property

Boiling point:: 85°C/0.75mm
Density: 1.095±0.06 g/cm3(Predicted)
refractive index: 1.60
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: clear liquid
pka: 4.37±0.20(Predicted)
color: Colorless to Yellow to Orange
Water Solubility: Sparingly soluble in water.(0.26 g/L) (25°C),
InChI: InChI=1S/C8H9NO/c1-2-4-8-7(3-1)9-5-6-10-8/h1-4,9H,5-6H2
InChIKey: YRLORWPBJZEGBX-UHFFFAOYSA-N
SMILES: O1C2=CC=CC=C2NCC1

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D5104
Product name: 3,4-Dihydro-2H-1,4-benzoxazine
Packaging: 1G
Price: $68
Updated: 2025/07/31

TRC

Product number: D451430
Product name: 3,4-Dihydro-2h-1,4-benzoxazine
Packaging: 1g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD76095
Product name: 3,4-Dihydro-2h-1,4-benzoxazine
Packaging: 1g
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD76095
Product name: 3,4-Dihydro-2h-1,4-benzoxazine
Packaging: 2g
Price: $100
Updated: 2021/12/16

Matrix Scientific

Product number: 031194
Product name: 3,4-Dihydro-2H-1,4-benzoxazine hydrochloride
Packaging: 1g
Price: $122
Updated: 2021/12/16

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Benzomorpholine Chemical Properties,Usage,Production

Uses

It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.

Definition

ChEBI: 3,4-Dihydro-2H-1,4-benzoxazine is a benzoxazine.

Synthesis

106-93-4

95-55-6

5735-53-5

To a suspension of 2-aminophenol (1.0 g, 9.2 mmol) and potassium carbonate (6.36 g, 46 mmol) in anhydrous DMF (10 mL) was added 1,2-dibromoethane (2.59 g, 13.8 mmol). The reaction mixture was heated at 125 °C with stirring for 15 hours. After completion of the reaction, it was cooled to room temperature, the mixture was poured into crushed ice and extracted with ethyl acetate (3 × 20 mL). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by silica gel column chromatography with ethyl acetate/petroleum ether (1:10, v/v) as eluent to afford 3,4-dihydro-2H-benzo[b][1,4]oxazine as a red oil (0.81 g, 65% yield). The product was analyzed by LC-MS (ES-API): retention time 7.51 min; calculated value C8H9NO [M+H]+ 136.1, measured value 136.1.

References

[1] Tetrahedron Letters, 2006, vol. 47, # 44, p. 7823 - 7826
[2] Patent: WO2011/47432, 2011, A1. Location in patent: Page/Page column 88
[3] Heterocyclic Communications, 2012, vol. 18, # 3, p. 143 - 146
[4] Patent: WO2010/51374, 2010, A1. Location in patent: Page/Page column 132
[5] Patent: EP2172453, 2010, A1. Location in patent: Page/Page column 13

Benzomorpholine Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzomorpholine Suppliers

Americas 1 CHINA 120 Europe 1 France 1 Germany 3 India 4 Japan 1 Ukraine 1 United Kingdom 5 United States 14 Global 151

Accela ChemBio Inc.

Tel: +1(858) 699-3322
Fax: +1(858) 876-1948
Email: marketing@accelachem.com
Country: United States
ProdList: 6024
Advantage: 65

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 21193
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Advanced Chemical Intermediates Ltd.

Tel: --
Fax: --
Email: enquiries@acints.com
Country: United States
ProdList: 4893
Advantage: 58

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Alfa Chemistry

Tel: --
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Email: info@Alfa-Chemistry.com
Country: United States
ProdList: 6814
Advantage: 0

SynQuest Laboratories, Inc.

Tel: --
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Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Combi-Blocks Inc.

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Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Ryan Scientific, Inc.

Tel: --
Fax: --
Email: ryan.reichlyn@ryansci.com
Country: United States
ProdList: 6439
Advantage: 60

Aagile Labs Division of Tyger Scientific

Tel: --
Fax: --
Email: tygersci@yahoo.com
Country: United States
ProdList: 6568
Advantage: 68

ChemBridge Corporation

Tel: --
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Email: resupply@chembridge.com
Country: United States
ProdList: 6648
Advantage: 70

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View Lastest Price from Benzomorpholine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 3,4-Dihydro-2H-1,4-benzoxazine 5735-53-5
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Henan Aochuang Chemical Co.,Ltd.

Product: Benzomorpholine 5735-53-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Shanghai Rlavie Technology Co ltd

Product: Benzomorpholine 5735-53-5
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: 100kgs/month
Release date: 2022-01-03

5735-53-5, BenzomorpholineRelated Search:

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7-Oxa-10-azabicyclo[4.4.0]deca-1,3,5-triene

AKOS BC-1149

AKOS BBS-00002717

2,3-dihydro-1,4-benzoxazine

Benzomorpholine(3,4-Dihydro-2H-1,4-benzoxazine)

3,4-DIHYDRO-2H-1,4-BENZOXAZINE

BENZOMORPHOLINE

CHEMBRDG-BB 4005008

3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE

3,4-Dihydro-2H-1,4-benzoxazine hydrochloride

3,4-Dihydro-2H-1,4-benzoxazine, 97+%

3,4-dihydro-2H-1,4-benzoxazine(SALTDATA: FREE)

3,4-Dihydro-2H-benzo[1,4]oxazine

2H-1,4-Benzoxazine, 3,4-dihydro-

5735-53-5

pharmacetical

Heterocycles series