ChemicalBook > CAS DataBase List > 2,4,5-Trimethoxybenzaldehyde

2,4,5-Trimethoxybenzaldehyde

Product Name
2,4,5-Trimethoxybenzaldehyde
CAS No.
4460-86-0
Chemical Name
2,4,5-Trimethoxybenzaldehyde
Synonyms
Asarylaldehyde;ASARALDEHYDE;Gazarin;Benzaldehyde, 2,4,5-trimethoxy-;ASARONALDEHYDE;NCI-C61632;Azarylaldehyde;2,4,5-Trimethoxy;AKOS BBS-00003175;Asarylaldehyde-RM
CBNumber
CB3251399
Molecular Formula
C10H12O4
Formula Weight
196.2
MOL File
4460-86-0.mol
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2,4,5-Trimethoxybenzaldehyde Property

Melting point:
112-114 °C (lit.)
Boiling point:
140°C 4mm
Density 
1.2166 (rough estimate)
refractive index 
1.5550 (estimate)
Flash point:
140°C/4mm subl.
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Fine Crystalline Powder
color 
White to light beige
Water Solubility 
<0.1 g/100 mL at 22 ºC
Sensitive 
Air Sensitive
BRN 
1951403
InChIKey
IAJBQAYHSQIQRE-UHFFFAOYSA-N
LogP
1.634 (est)
CAS DataBase Reference
4460-86-0(CAS DataBase Reference)
NIST Chemistry Reference
Benzaldehyde, 2,4,5-trimethoxy-(4460-86-0)
EPA Substance Registry System
2,4,5-Trimethoxybenzaldehyde (4460-86-0)
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Safety

Hazard Codes 
C
Risk Statements 
36/37/38-34
Safety Statements 
22-24/25-45-36/37/39-27-26
WGK Germany 
3
RTECS 
CU8460000
TSCA 
Yes
HS Code 
29124990
Hazardous Substances Data
4460-86-0(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL82478
Product name
Asarylaldehyde
Purity
phyproof? Reference Substance
Packaging
100mg
Price
$231
Updated
2025/07/31
Sigma-Aldrich
Product number
132152
Product name
2,4,5-Trimethoxybenzaldehyde
Purity
98%
Packaging
25g
Price
$68.7
Updated
2023/06/20
Sigma-Aldrich
Product number
132152
Product name
2,4,5-Trimethoxybenzaldehyde
Purity
98%
Packaging
100g
Price
$130
Updated
2023/06/20
TCI Chemical
Product number
T1172
Product name
2,4,5-Trimethoxybenzaldehyde
Purity
>98.0%(GC)
Packaging
5g
Price
$16
Updated
2025/07/31
TCI Chemical
Product number
T1172
Product name
2,4,5-Trimethoxybenzaldehyde
Purity
>98.0%(GC)
Packaging
25g
Price
$46
Updated
2025/07/31
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2,4,5-Trimethoxybenzaldehyde Chemical Properties,Usage,Production

Description

2,4,5-Trimethoxybenzaldehyde (2,4,5-TMBA) is a natural cyclooxygenase-2 (COX-2) activity inhibitor that is present in carrot seeds (Daucus carota L.) and can be synthesised using Indonesia Sweet Flag (Acorus calamus) as a raw material. 2,4,5-TMBA may serve as a synthetic intermediate component for various pharmaceuticals. In addition, 2,4,5-TMBA is also considered a candidate drug for oral non-steroidal anti-inflammatory drugs (NSAIDs)[1].
[1] LERRICK R I. Synthesis of Nonsteroidal Anti-Inflammatory Drug (NSAID) 2,4,5-Trimethoxybenzaldehyde from Indonesian Calamus oil and Its In Silico Pharmacokinetic Study[J]. Canadian Journal of Chemistry, 2022, 20 1. DOI:10.1139/cjc-2022-0121.

Chemical Properties

white to light beige fine crystalline powder

Uses

fly attractant

Uses

A selective Cox-2 inhibitor.

Uses

2,4,5-Trimethoxybenzaldehyde is used in the synthesis of stilbene and hydrostibene derivatives as potential anticancer agents, inhibiting tubulin. Also used in the synthesis of HIV-RT inhibitors.

Definition

ChEBI: 2,4,5-trimethoxybenzaldehyde is a carbonyl compound.

General Description

Beige powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2,4,5-Trimethoxybenzaldehyde is light sensitive. .

Health Hazard

SYMPTOMS: Symptoms of exposure to related compounds are skin and gastrointestinal tract irritation, sensitization, blistering, nausea, vomiting, diarrhea, urinary tract irritation, initial excitement, convulsions and central nervous system depression.

Fire Hazard

Flash point data for 2,4,5-Trimethoxybenzaldehyde are not available, but 2,4,5-Trimethoxybenzaldehyde is probably combustible.

Biological Activity

2,4,5-Trimethoxybenzaldehyde (2,4,5-TMBA) is a bitter principle present in plant seeds, leaves, and roots. 2,4,5-TMBA exhibits anti-inflammatory, anti-adipogenic, and immunomodulatory activities. 2,4,5-TMBA has significant inhibitory effects on COX-2 activity. COX-2 not only plays a crucial role in inflammatory reactions, but also participates in the adipogenesis of 3T3-L1 cells via its derivative 15-deoxy-D12,14 prostaglandin (PG)J2 (15d-PGJ2). Studies indicate that 2,4,5-TMBA further inhibits lipogenesis and promotes lipolysis in 3T3-L1 adipocytes. This is closely associated with 2,4,5-TMBA's downregulation of proteins critical for adipogenesis, including CCAAT/enhancer-binding proteins (C/EBP) α, β, δ, peroxisome proliferator-activated receptor (PPAR)γ2, acyl-CoA carboxylase (ACC), fatty acid synthase (FAS), and perilipin A in preadipocytes. In addition, carrot seed extracts rich in 2,4,5-TMBA exhibit immunomodulatory activity.

2,4,5-Trimethoxybenzaldehyde Preparation Products And Raw materials

Raw materials

1,4-Benzoquinone

Preparation Products

trans-2,4,5-Trimethoxycinnamic acid Scopoletin
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2,4,5-Trimethoxybenzaldehyde Suppliers

Australia 1 Belgium 3 Canada 3 China 435 Czech Republic 1 Europe 2 France 1 Germany 5 India 13 Japan 3 Slovakia 1 Switzerland 3 The Netherlands 2 Ukraine 3 United Kingdom 22 United States 61 USA 1 Global 560
Acros Organics (Part of Thermo Fisher Scientific )
Tel
--
Fax
--
Email
fo@acros.com
Country
Belgium
ProdList
3824
Advantage
58
TCI EUROPE N.V.
Tel
--
Fax
--
Email
sales@tcieurope.be
Country
Belgium
ProdList
2200
Advantage
66
Acros Organics
Tel
--
Fax
--
Email
info@acros.com
Country
Belgium
ProdList
6772
Advantage
81
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View Lastest Price from 2,4,5-Trimethoxybenzaldehyde manufacturers

Shandong Vital Biotechnology Co., Ltd.
Product
2,4,5-Trimethoxybenzaldehyde 4460-86-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100tons
Release date
2025-11-20
Hebei Chuanghai Biotechnology Co., Ltd
Product
2,4,5-Trimethoxybenzaldehyde 4460-86-0
Price
US $9.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-29
Hebei Zhuanglai Chemical Trading Co Ltd
Product
2,4,5-Trimethoxybenzaldehyde 4460-86-0
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-17

4460-86-0, 2,4,5-TrimethoxybenzaldehydeRelated Search:

Trimethyl phosphite Mesitaldehyde 3-(Trifluoromethyl)benzaldehyde Benzaldehyde p-Anisaldehyde 3-Methoxybenzaldehyde o-Anisaldehyde 2-(Trifluoromethyl)benzaldehyde (Trifluoromethoxy)benzene 3,4,5-Trimethoxyphenol 4-(Trifluoromethoxy)aniline 4',6,7-Trimethoxyisoflavone 2,4,5-Trimethoxybenzoic acid 3,4,5-TRIMETHOXYBENZALDEHYDE (TMBA),3,4,5-TRIMETHOXYBENZALDEHYDE pure,3,4,5-Trimethoxybenzaldehyde,~98%,3,4,5-TRIMETHOXYBENZALDEHYDE 2,4,6-Trimethoxybenzaldehyde98%,2,4,6-TRIMETHOXYBENZALDEHYDE 3',5-DIHYDROXY-4',6,7-TRIMETHOXYFLAVONE SCUTELLAREIN TETRAMETHYL ETHER 2,3,4-Trimethoxybenzaldehyde

  • ASARONALDEHYDE
  • ASARALDEHYDE
  • Asarylaldehyde
  • Azarylaldehyde
  • Gazarin
  • NCI-C61632
  • 2,4,5-trimethyl ether
  • 2,4,5-TRIMETHOXYBENZALDEHYDE
  • 3,4,6-trimethoxybenzaldehyde
  • AKOS BBS-00003175
  • 2,4,5-trimethoxybenzaldehdye
  • 2,4,5-Trimethoxy-benzaldehyd
  • 2,4,5-Trimethoxybenzaldheyde
  • 2,4,5-Trimethoxy
  • 2.4.5-TRIMOTHOXYBENZALDEHYDE
  • 2,4,5-TRIMETHOXYBENZALDEHYDE 98+% (GC)
  • Benzaldehyde, 2,4,5-trimethoxy-
  • 2,4,5-Trimethoxybenzaldehyde,98%
  • 2,4,5-Trimethoxybenz
  • 2,4,5-Trihydroxybenzaldehyde triMethyl ether
  • 5-TriMethoxybenzaldehyde
  • 2,4,5-TriMethoxybenzaldehyde, 98% 25GR
  • Asaraldehyde (Asaronaldehyde)
  • 2,4,5-TriMehoxybenzaldehdye
  • 2,4,5-Trimethoxybenzaldehyde Vetec(TM) reagent grade, 98%
  • 2,4,5-Trimethoxybenzaldehyde ASARONALDEHYDE
  • 5-trimethoxy-Benzaldehyd
  • Trimetazidine Impurity 10
  • 2,4,5-Trimethoxybenzaldehyde, Asaronaldehyde, Asaraldehyde, Asarylaldehyde
  • 2,4,5-TrimethoxybenzaL
  • 2,4,5-Trimethoxybenzaldehyde 99% (Asaraldehyde)
  • 2, 4, 5-Trimethoxybenzaldehyde CAS 4460-86-0 high quality
  • Asaraldehyde:2.4.5-trimethoxy-Benzaldehyde
  • 2,4,5-Trimethoxybenzaldehyde/Asaraldehyde
  • 2,4,5-Trimethoxybenzaldehyde CAS
  • Asarylaldehyde-RM
  • 4460-86-0
  • 460-86-0
  • CH3O3C6H2CHO
  • ALDEHYDE
  • Organic Building Blocks
  • Aldehydes
  • Building Blocks
  • Carbonyl Compounds
  • C10 to C21
  • Inhibitors
  • Aromatic Aldehydes & Derivatives (substituted)
  • FINE Chemical & INTERMEDIATES
  • bc0001