ChemicalBook > CAS DataBase List > (±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride

(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride

Product Name
(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride
CAS No.
72795-01-8
Chemical Name
(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride
Synonyms
CS-769;ICI 118;551 hydrochloride;CI 118551 Hydrochloride;ICI 118,551 hydrochloride, >=98%;Zenidolol (ICI-118551) Hydrochloride;ICI 118,551 hydrochloride, 10 mM in DMSO;ICI 118551 hydrochloride, beta2 adrenoceptor antagonist;(2R,3R)-3-(isopropylamino)-1-((7-methyl-2,3-dihydro-1H-inden-4-yl)oxy)butan-2-ol hydrochloride;(2R,3R)-rel-1-[(2,3-Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride (1:1)
CBNumber
CB32518939
Molecular Formula
C17H28ClNO2
Formula Weight
313.87
MOL File
72795-01-8.mol
More
Less

(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride Property

storage temp. 
desiccated
solubility 
DMSO : 25 mg/mL (79.65 mM; Need ultrasonic)H2O : 12.5 mg/mL (39.83 mM; Need ultrasonic)
form 
powder
color 
white
Water Solubility 
H2O: >10mg/mL
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I127
Product name
ICI 118,551 hydrochloride
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$270
Updated
2025/07/31
Sigma-Aldrich
Product number
I127
Product name
ICI 118,551 hydrochloride
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$960
Updated
2025/07/31
Cayman Chemical
Product number
15591
Product name
ICI 118551 (hydrochloride)
Purity
≥99%
Packaging
10mg
Price
$145
Updated
2024/03/01
Cayman Chemical
Product number
15591
Product name
ICI 118551 (hydrochloride)
Purity
≥99%
Packaging
50mg
Price
$616
Updated
2024/03/01
TRC
Product number
I163850
Product name
ICI 118,551 hydrochloride
Packaging
5mg
Price
$140
Updated
2021/12/16
More
Less

(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride Chemical Properties,Usage,Production

Description

ICI 118551 is a potent, selective antagonist of the β2-adrenergic receptor (Ki = 0.7 nM for the β2receptor, compared with 49.5 and 611 nM for β1 and β3 receptors, respectively). It is active in vivo and is often used to evaluate the actions of adrenergic receptor agonists.

Uses

ICI 118,551 hydrochloride has been used:

  • to block β-adrenergic signaling in various experiments
  • to counteract degradation by endogenous T-lymphocyte monoamine oxidases
  • to determine the specific receptor subtype necessary for isoproterenol to induce up-regulation of gene transcripts

Uses

The (R,R)-enantiomer of ICI 118551 as highly selective β2-adrenoceptor antagonist. The S,S-enantiomer is the most potent.

Biochem/physiol Actions

ICI 118,551 has been used to treat vasomotor migraines and somatic troubles related to anxiety state.

in vivo

Zenidolol (ICI-118551; 0.2 mg/kg) hydrochloride injected into the jugular vein of the mice, reduces systolic pressure in the pulmonary circuit but not systemic arterial pressure[2].

IC 50

β adrenergic receptor

storage

Store at RT

References

[1] N M DEIGHTON. Characterization of the beta adrenoceptor subtype(s) mediating the positive inotropic effects of epinine, dopamine, dobutamine, denopamine and xamoterol in isolated human right atrium.[J]. Journal of Pharmacology and Experimental Therapeutics, 1992, 262 2: 532-538.
[2] NANCY J. ROTHWELL  Deepak K S  Michael J Stock. Changes in tissue blood flow and β-receptor density of skeletal muscle in rats treated with the β2-adrenoceptor agonist clenbuterol[J]. British Journal of Pharmacology, 1987, 90 3: 601-607. DOI: 10.1111/j.1476-5381.1987.tb11211.x
[3] IL-MAN KIM. Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2008: 14555-14560. DOI: 10.1073/pnas.0804745105

(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride Suppliers

Canada 1 China 66 India 2 United Kingdom 1 United States 16 Global 86
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
+86 (21) 5895-8628
Email
sales@uhnshanghai.com
Country
China
ProdList
998
Advantage
58
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58

72795-01-8, (±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochlorideRelated Search:

Hydrotalcite Tizanidine Tizanidine hydrochloride Carvedilol (-)-CYANOPINDOLOL HEMIFUMARATE Propranolol hydrochloride GUANFACINE HCL L-NORADRENALINE BITARTRATE Rauwolscine hydrochloride Wandonorm GUANFACINE HCL

  • (±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride
  • (2R,3R)-rel-1-[(2,3-Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride (1:1)
  • ICI 118,551 hydrochloride, >=98%
  • CS-769
  • CI 118551 Hydrochloride
  • 551 hydrochloride
  • ICI 118
  • ICI118551,ICI 118,551 hydrochloride,ICI 118551,Adrenergic Receptor,ICI-118551,Inhibitor,Beta Receptor,inhibit,ICI 118,551
  • (2R,3R)-3-(isopropylamino)-1-((7-methyl-2,3-dihydro-1H-inden-4-yl)oxy)butan-2-ol hydrochloride
  • ICI 118551 hydrochloride, beta2 adrenoceptor antagonist
  • ICI 118,551 hydrochloride, 10 mM in DMSO
  • Zenidolol (ICI-118551) Hydrochloride
  • (±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride
  • 72795-01-8
  • Aromatics
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals