PD 98059

Product Name: PD 98059
CAS No.: 167869-21-8
Chemical Name: PD 98059
Synonyms: 2-(2-AMINO-3-METHOXYPHENYL)-4H-CHROMEN-4-ONE;CS-398;PD 98059;PD090859;PD 098,059;PD 98059 NEW;PD 98059, 99+%;Amino chromone;PD 98059, >=98%;PD-98059/PD98059
CBNumber: CB3256152
Molecular Formula: C16H13NO3
Formula Weight: 267.28
MOL File: 167869-21-8.mol

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PD 98059 Property

Melting point:: 164～165℃
Boiling point:: 453.1±45.0 °C(Predicted)
Density: 1.300±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: ethanol: 0.6 mg/mL
pka: 1.21±0.10(Predicted)
form: solid
color: yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey: QFWCYNPOPKQOKV-UHFFFAOYSA-N
CAS DataBase Reference: 167869-21-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 22-60-36
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
HS Code: 29322090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P215
Product name: PD 98,059
Purity: solid
Packaging: 1mg
Price: $78.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 513000
Product name: PD 98059 - CAS 167869-21-8 - Calbiochem
Packaging: 5mg
Price: $159
Updated: 2024/03/01

Sigma-Aldrich

Product number: 513001
Product name: InSolution? PD 98059
Packaging: 1ml
Price: $172
Updated: 2024/03/01

Sigma-Aldrich

Product number: 19-143
Product name: PD 98059
Packaging: 5MG
Price: $188
Updated: 2024/03/01

Alfa Aesar

Product number: J64485
Product name: 2'-Amino-3'-methoxyflavone, 99%
Packaging: 10mg
Price: $105.65
Updated: 2024/03/01

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PD 98059 Chemical Properties,Usage,Production

Description

PD 98059 is a noncompetitive inhibitor of the MAPK pathway. It prevents the activation of MEK by Raf or MEK kinase (a MAP3K) with an IC₅₀ value of 2-7 μM but does not inhibit Raf-activated MAP2K1. It inhibits Raf activation of MAP2K2 with an IC₅₀ value of 50 μM. PD 98059 also phosphorylates and activates AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC₅₀ = 35 μM in HEK293 cells). It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC).

Uses

PD 98059 is a selective inhibitor of MEK and blocker of MAPK.

Definition

ChEBI: A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'

General Description

Selective, reversible, and cell-permeable inhibitor of MAP kinase kinase (MEK) that acts by inhibiting the activation of MAP kinase and subsequent phosphorylation of MAP kinase substrates. Pretreatment of PC-12 cells with PD 98059 completely blocks the 4-fold increase in MAP kinase activity produced by nerve growth factor (NGF; IC₅₀ = 2 μM); however, it has no effect on NGF-dependent tyrosine phosphorylation of the p140^trk receptor or its substrate Shc and does not block NGF-dependent activation of PI 3-kinase. Blocks LPS-induced activation of TNF-α gene expression. Inhibits cell growth and reverses the phenotype of ras-transformed BALB3T3 mouse fibroblasts and rat kidney cells. A 5 mg/ml solution of PD 98059 (Cat. No. 513001) in anhydrous DMSO is also available.

Biological Activity

Specific inhibitor of mitogen-activated protein kinase kinase (MAPKK / MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC 50 = 2-7 μ M). Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G 1 arrest by blocking p53-dependent p21 induction. Also available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™ .

Biochem/physiol Actions

PD 98,059 is a flavonoid and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock. It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.

storage

Room temperature

References

1) Alessi et al. (1995), PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo; J. Biol. Chem., 270 27489 2) Dudley et al. (1995), A synthetic inhibitor of the mitogen-activated protein kinase cascade; Proc. Natl. Acad. Sci., 92 7686 3) Hotokezaka et al. (2002) U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells; J. Biol. Chem., 277 47366 4) Xiaoxia et al. (2004) BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways; Proc. Natl. Acad. Sci. USA 101 6027

PD 98059 Preparation Products And Raw materials

Raw materials

Preparation Products

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PD 98059 Suppliers

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View Lastest Price from PD 98059 manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-(2-aMino-3-Methoxyphenyl)-4H-chroMen-4-one 167869-21-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: InSolution PD 98059 167869-21-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
Release date: 2019-08-31

Career Henan Chemical Co

Product: InSolution PD 98059 167869-21-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
Release date: 2019-08-31

167869-21-8, PD 98059Related Search:

PD153035 HCl PD 166285 PD173955 PD 0325901 PD 166793 PD184352 PD318088 1-(2-BROMOPHENYL)-2-THIOUREA 3'-Amino-4'-methoxyacetanilide p-Anisidine-3-sulfonic acid U0126-EtOH WORTMANNIN 1,9-Pyrazoloanthrone SB 203580 LY 294002 HYDROCHLORIDE Rapamycin PD158780 3-METHOXYFLAVONE

2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE

2-(2-AMINO-3-METHOXY-PHENYL)CHROMEN-4-ONE

2'-AMINO-3'-METHOXYFLAVONE

PD 98059 in Solution

PD 98059

PD 098,059

2-(2-AMINO-3-METHOXYPHENYL)-4H-CHROMEN-4-ONE

PD 098,059 (2-(2-AMINO-3-METHOXYPHENYL)- 4H-1-BENZOPYRAN-4-ONE

PD 98059, 99+%

4H-1-Benzopyran-4-one, 2-(2-amino-3-methoxyphenyl)-

4H-1-Benzopyran-4-one,2-(2-amino-3-methoxyphenyl)-(9CI)

PD090859

PD-98059/PD98059

2-(2-AMino-3-Methoxyphenyl)chroMone

2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one PD 98059

PD 98059 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

PD 98059, >=98%

InSolution? PD 98059

2-(2-Amino-3-methoxy-phenyl)chromen-4-one, 98%, a non-ATP competitive MEK inhibitor

PD 98059 NEW

CS-398

PD 98059 - NSC 679828

InSolution PD 98059 - CAS 167869-21-8 - Calbiochem

PD 98059 - CAS 167869-21-8 - Calbiochem

Amino chromone

2-(2-Amino-3-methoxyphenyl)chromone &gt

PD 98059 USP/EP/BP

PD 98059 (DMSO solution)

PD 98059, MEK1 inhibitor

PD 98059 (DMSO solution), MEK1 inhibitor

167869-21-8

C16H13O3N

Specific inhibitor of the activation of mitogen-activated protein kinase kinase

Mitogen-Activated Protein Kinase Kinase (MAPKK)

Kinase/Phosphatase Biology

Serine/Threonine Kinase Inhibitors

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Inhibitors

inhibitor

MAPK

Signalling

pharmacetical

Protein Kinase

FLAVONE