ChemicalBook > CAS DataBase List > MAY-262611

MAY-262611

Product Name
MAY-262611
CAS No.
1123231-07-1
Chemical Name
MAY-262611
Synonyms
DKK1;CS-1296;MAY-262611;WAY-262611;Wnt/β-catenin;Wnt/β-catenin;Dickkopf-1，DKK-1;WAY262611; WAY 262611;WAY-262611, 10 mM in DMSO;Human DKK1 Protein, His Tag
CBNumber
CB32628072
Molecular Formula
C20H22N4
Formula Weight
318.42
MOL File
1123231-07-1.mol
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MAY-262611 Property

Boiling point:
544.8±42.0 °C(Predicted)
Density 
1.169±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
form 
Powder
pka
10.13±0.29(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17704
Product name
WAY-262611
Purity
≥98%
Packaging
1mg
Price
$26
Updated
2024/03/01
Cayman Chemical
Product number
17704
Product name
WAY-262611
Purity
≥98%
Packaging
5mg
Price
$83
Updated
2024/03/01
Cayman Chemical
Product number
17704
Product name
WAY-262611
Purity
≥98%
Packaging
10mg
Price
$141
Updated
2024/03/01
Cayman Chemical
Product number
17704
Product name
WAY-262611
Purity
≥98%
Packaging
25mg
Price
$287
Updated
2024/03/01
Usbiological
Product number
355278
Product name
DKK1
Packaging
48Tests
Price
$588
Updated
2021/12/16
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MAY-262611 Chemical Properties,Usage,Production

Uses

WAY-262611 is a Wnt/β-Catenin agonist that increases bone formation rate with an EC50 of 0.63 μM in TCF-Luciferase assay. WAY-262611 is also a Dkk1 inhibitor[1].

Definition

ChEBI: [1-[4-(2-naphthalenyl)-2-pyrimidinyl]-4-piperidinyl]methanamine is a member of naphthalenes.

in vivo

WAY-262611 has excellent pharmacokinetic properties and shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration. Calvariae from wt mice treated with WAY-262611 shows statistically increased BFR, while similarly treated KO animals are no different from control. This indicates that WAY-262611 is acting via the Wntβ-catenin pathway and most likely through inhibition of Dkk-1[1].

References

[1] Pelletier JC, et al. (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate. J Med Chem. 2009 Nov 26;52(22):6962-5. DOI:10.1021/jm9014197
[2] L Enochson, et al. GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition. Osteoarthritis Cartilage. 2014 Apr;22(4):566-77. DOI:10.1016/j.joca.2014.02.004

MAY-262611 Preparation Products And Raw materials

Raw materials

Preparation Products

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MAY-262611 Suppliers

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View Lastest Price from MAY-262611 manufacturers

Dingwang Technology (Wuhan) Co., Ltd.
Product
WAY-262611 1123231-07-1
Price
US $0.00-0.00/gram
Min. Order
10gram
Purity
99%
Supply Ability
20 tons
Release date
2023-05-24

1123231-07-1, MAY-262611Related Search:

WAY 181187 3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester SAM-315 N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE WAY 100635 1,3-Benzenediol, 4-[1-(2-propenyl)-7-(trifluoromethyl)-1H-indazol-3-yl]- BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) WAY 208466 dihydrochloride WAY-204688 WAY-600 WAY-151932 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol

  • 1-[4-(2-Naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine MAY-262611
  • MAY-262611
  • DKK1
  • 4-PiperidineMethanaMine, 1-[4-(2-naphthalenyl)-2-pyriMidinyl]-
  • WAY-262611
  • 1-[4-(2-Naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine
  • 1-{1-[4-(2-Naphthyl)-2-pyrimidinyl]-4-piperidinyl}methanamine
  • Wnt/β-catenin
  • CS-1296
  • WAY262611; WAY 262611
  • Recombinant Human DKK-1/DKK1 Protein, 8* His Tag
  • Recombinant Mouse Dkk-1 Protein, 8*His Tag
  • Human DKK1 Protein, His Tag
  • Dickkopf-1，DKK-1
  • WAY 262611, Wnt pathway activator
  • WAY-262611, 10 mM in DMSO
  • Wnt/β-catenin
  • 1123231-07-1
  • 2530-83-0
  • 123231-07-1
  • Inhibitors