API-2

Product Name: API-2
CAS No.: 35943-35-2
Chemical Name: API-2
Synonyms: TCN;IAP1;MIHC;MYHL;BBMI;API-2;BIRC3;RNF49;MYO1A;DFNA48
CBNumber: CB3270000
Molecular Formula: C13H16N6O4
Formula Weight: 320.3
MOL File: 35943-35-2.mol

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API-2 Property

Melting point:: 207 °C (decomp)
Boiling point:: 459.21°C (rough estimate)
Density: 1.2633 (rough estimate)
refractive index: 1.7000 (estimate)
storage temp.: Store at RT
solubility: DMSO: >10mg/mL
form: powder
pka: 12.35±0.70(Predicted)
color: tan
InChIKey: HOGVTUZUJGHKPL-HTVVRFAVSA-N

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Safety

WGK Germany: 3
RTECS: RY8455000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T3830
Product name: Triciribine hydrate
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $274
Updated: 2024/03/01

Sigma-Aldrich

Product number: 124038
Product name: InSolution? Akt Inhibitor V, Triciribine
Packaging: 2mg
Price: $345
Updated: 2024/03/01

Sigma-Aldrich

Product number: SAB1303874
Product name: ANTI-MYO1A (CENTER S291) antibody produced in rabbit
Purity: IgG fraction of antiserum, buffered aqueous solution
Packaging: 400μL
Price: $461
Updated: 2023/01/07

Cayman Chemical

Product number: 10010237
Product name: Triciribine
Purity: ≥98%
Packaging: 1mg
Price: $47
Updated: 2024/03/01

Cayman Chemical

Product number: 10010237
Product name: Triciribine
Purity: ≥98%
Packaging: 5mg
Price: $107
Updated: 2024/03/01

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API-2 Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is also a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.

Uses

Triciribine hydrate has been used to study the effect of diethyldithiocarbamate (DDC) on matrix metalloproteinase-1 (MMP-1) in hepatic stellate cells¹. It has also been used to analyze ADAM 10 activation by (-)-epigallocatechin-3-gallate (EGCG) in N2a cells overexpressing Swedish mutant APP (SweAPP N2a cells)².

Definition

ChEBI: Triciribine is a nucleoside analogue in which the nucleobase portion is a 1,4,5,6,8-pentaazaacenaphthylene ring system substituted with an amino group at position 3, and a methyl group at position 5 and is bound to the beta-D-ribofuranosyl moiety by an N(1)-glycosidic linkage. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor.

Biological Activity

Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3 β and AFX. In vitro, induces apoptosis and growth arrest preferentially in human cancer cells with elevated levels of Akt. In mice, potently and selectively inhibits growth of Akt-overexpressing tumors. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.

Biochem/physiol Actions

Triciribine is a highly selective Akt/PKB inhibitor, that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3.

storage

Store at RT

API-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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API-2 Suppliers

Canada 1 China 121 Germany 2 India 1 Switzerland 1 United Kingdom 4 United States 24 Global 154

Target molecule Corp.

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View Lastest Price from API-2 manufacturers

Wuhan Haorong Biotechnology Co.,Ltd

Product: API-2 / TRICIRIBINE 35943-35-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000
Release date: 2023-08-07

Wuhan Nutra Biotechnology Co.,Ltd

Product: Triciribine hydrate;TCN 35943-35-2
Price: US $0.00-0.00/g
Min. Order: 10g
Purity: 98%+
Supply Ability: 100kgs
Release date: 2021-05-27

Wuhan Cell Pharmaceutical Co., Ltd

Product: API-2 35943-35-2
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2023-04-14

35943-35-2, API-2Related Search:

triciribine phosphate,Triciribine 5'-phosphate API API-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine API94-02UNLEADEDGASOLINEVAPOUR API`sIntermediate LUPRAGEN(R) API,N-(3-AMINOPROPYL)IMDAZOLE (JD API) Acenaphthene 7-DEAZA-2'-DEOXYADENOSINE TUBERCIDIN N-METHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE Sulphate API broth,Sulphate API agar TRICIRIBINE,[3H] G1969-85001 API-TOF-REFERENCE MASS apoptosis inhibitor API5L1 ACTIVE PHARMACEUTICAL INGREDIENTS (API) MULTIPLIER PE-SCIEX API2000 SULPHATE REDUCING AGAR ACC. TO API

API-2

6-AMINO-4-METHYL-8-(BETA-D-RIBOFURANOSYL)-4H,8H-PYRROLO[4,3,2-DE]PYRIMIDO[4,5-C]PYRIDAZINE

AKT/PKB SIGNALING INHIBITOR-2

AKT INHIBITOR V

1,5-DIHYDRO-5-METHYL-1-BETA-D-RIBOFURANOSYL-1,4,5,6,8-PENTAAZAACENAPHTHYLEN-3-AMINE

1,4,5,6,8-pentaazaacenaphthylen-3-amine,1,5-dihydro-5-methyl-1-beta-d-ribofura

API-2 (Tricirbine)

TRICIRIBINE

NSC 154020

TCN

1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine

(1,4,5,6,8-Pentaazaacenaphthylen-3-aMine,1,5-dihydro-5-Methyl-1-b-D-ribofuranosyl-)

6-AMino-4-Methyl-8-(β-D-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyriMido[4,5-c]pyridazine

(2R,3R,4S,5R)-2-(3-aMino-5-Methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol

VD-0002

1,5-Dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine Triciribine

Triciribine 1,5-Dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine

Inhibitor V

(1R,2S,3R,5R)-3-(3-Amino-5-methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-5-(hydroxymethyl)c

InSolution? Akt Inhibitor V, Triciribine

Triciribine hydrate

ANTI-CIAP2 (BIRC3)(N-TERMINAL) antibody produced in rabbit

BIRC3

IAP1

MIHC

RNF49

ANTI-MYO1A (CENTER S291) antibody produced in rabbit

Brush border myosin I

MYHL

Myosin-Ia

Anti-MYO1A antibody produced in rabbit

BBMI

DFNA48

MYO1A

Anti-Dfna48

Anti-Myhl

Anti-Myosin ia

Triciribine, >=98%

CS-542

API-2; NSC 154020; TCN

CS-690

Triciribine, NSC 154020, TCN

InSolution Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem

1,4,5,6,8-pentaazaacenaphthylene,3-amino-1,5-dihydro-5-methyl-1-beta-d-ribof

3-amine

3-amino-1,5-dihydro-5-methyl-1-beta-d-ribofuranosyl-1,4,5,6,8-pentaazaacenap

4,5,6,8-pentaazaacenaphthylen-5-dihydro-5-methyl-1-beta-d-ribofuranosyl-1

hthylene

nosyl-

pentaazacentopthylene

uranosyl-

TRICYCLIC NUCLEOSIDE

Triciribine (NSC-154020)

Triciribine, 98%, a DNA synthesis inhibitor

Tricirbine

1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-β-D-ribofuranosyl-

API-2 USP/EP/BP

Triciribine 13CD3