VU 0360172

Product Name: VU 0360172
CAS No.: 1309976-62-2
Chemical Name: VU 0360172
Synonyms: VU 0360172;VU0360172.HCl;VU 0360172 hydrochloride;N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide hydrochloride;VU0360172 Hydrochloride N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]pyridine-3-carboxamide
CBNumber: CB32701733
Molecular Formula: C18H16ClFN2O
Formula Weight: 330.79
MOL File: 1309976-62-2.mol

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VU 0360172 Property

storage temp.: Store at -20°C
solubility: Soluble to 50 mM in DMSO and to 25 mM in ethanol
form: Powder
color: white to beige

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22074
Product name: VU0360172 (hydrochloride)
Packaging: 5mg
Price: $77
Updated: 2024/03/01

Cayman Chemical

Product number: 22074
Product name: VU0360172 (hydrochloride)
Packaging: 10mg
Price: $144
Updated: 2024/03/01

Cayman Chemical

Product number: 22074
Product name: VU0360172 (hydrochloride)
Packaging: 25mg
Price: $340
Updated: 2024/03/01

Cayman Chemical

Product number: 22074
Product name: VU0360172 (hydrochloride)
Packaging: 50mg
Price: $640
Updated: 2024/03/01

Tocris

Product number: 4323
Product name: VU0360172hydrochloride
Purity: ≥98%(HPLC)
Packaging: 50
Price: $724
Updated: 2021/12/16

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VU 0360172 Chemical Properties,Usage,Production

Uses

VU 0360172 is a an allosteric modulator for mGluR5. Displays efficacy in regulating CNS function in human embryonic kidney cell, rat cortical astrocyte and similar antipsychotic activity in rats.

Biological Activity

VU0360172 is a potent (EC50 = 16.6 nM), systemically active positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 5 (mGlu5). It is the first orally active mGlu5 PAM to be efficacious in an in vivo preclinical antipsychotic model, producing a dose-dependent reversal of amphetamine-induced hyperlocomotion. It was also found to reduce absence seizures in WAG/Rij rats and to inhibit pain.

storage

Store at +4°C

VU 0360172 Preparation Products And Raw materials

Raw materials

Preparation Products

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VU 0360172 Suppliers

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1309976-62-2, VU 0360172Related Search:

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VU 0360172

VU 0360172 hydrochloride

N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide hydrochloride

VU0360172 Hydrochloride N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]pyridine-3-carboxamide

VU0360172.HCl

1309976-62-2

C18H15FN2OHCl