ChemicalBook > CAS DataBase List > ML277

ML277

Product Name: ML277
CAS No.: 1401242-74-7
Chemical Name: ML277
Synonyms: ML277;CID-53347902;ML277 ，S0050;ML277;ML 277; ML-277;ML277, 10 mM in DMSO;ML-277|||CID-53347902;VU0458298-2, VU0458298-3;ML-277;ML 277;CID-53347902;CID53347902;CID 53347902;(R)-N-(4-(4-Methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide;(2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide
CBNumber: CB32715653
Molecular Formula: C23H25N3O4S2
Formula Weight: 471.59
MOL File: 1401242-74-7.mol

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ML277 Property

Density: 1.341±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 5 mg/ml
form: powder
pka: 8.37±0.70(Predicted)
color: white to beige

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Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0524
Product name: ML277
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $129.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0524
Product name: ML277
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $538
Updated: 2025/07/31

Cayman Chemical

Product number: 15193
Product name: ML-277
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 15193
Product name: ML-277
Purity: ≥95%
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Cayman Chemical

Product number: 15193
Product name: ML-277
Purity: ≥95%
Packaging: 10mg
Price: $172
Updated: 2024/03/01

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ML277 Chemical Properties,Usage,Production

Description

Potassium (K⁺) channels are categorized by their mode of activation and the number of transmembrane segments. The voltage-gated six-transmembrane K⁺ channels include KCNQ1, first recognized for its role in cardiac function and subsequently in hearing, gastrointestinal chloride secretion, and other processes. ML-277 is a potent activator of KCNQ1 channels (EC₅₀ = 260 nM). The EC₅₀ value of this compound at the related channels KCNQ2, KCNQ4, and hERG exceeds 30 μM. ML-277 potentiates both homomultimeric KCNQ1 channels and unsaturated heteromultimeric (KCNQ1/KCNE1) channels in model cardiomyocytes and augments delayed rectifier K⁺ current in cultured human cardiomyocytes.

Uses

ML277 has been used as the KCNQ1 activator to treat?cells in lung metastasis?assay.

Biochem/physiol Actions

ML277 is a potent activator of KCNQ1 (Kv7.1) channels with >100-fold selectivity versus KCNQ2 and KCNQ4 and no activity against the hERG potassium channel up to 30 μM. KCNQ1 is a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. Mutations in the KCNQ1 gene are associated with long QT syndrome (LQTS), a disorder in which the heart muscles take longer than normal to recover after each heart beat and can lead to dangerous arrhythmias such as atrial fibrillation. Activators of KCNQ1 channels could have potential use in treatments of LQTS. ML277 is the first selective and potent activator found, with an EC50 of 260 nM.

storage

Store at -20°C

References

[1] MARGRITH E. MATTMANN . Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective Kv7.1 (KCNQ1) potassium channel activator[J]. Bioorganic & Medicinal Chemistry Letters, 2012, 22 18: Pages 5936-5941. DOI: 10.1016/j.bmcl.2012.07.060
[2] HAIBO YU. Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2013: 8732-8737. DOI: 10.1073/pnas.1300684110

ML277 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ML277 manufacturers

Career Henan Chemical Co

Product: (2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-[(4-methylphenyl) sulfonyl]-2-piperidinecarboxamide 1401242-74-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

1401242-74-7, ML277Related Search:

VU0456810 ML 141 ML355 M348 ml390 (2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one ML364 ML365 ML385 ML216 ML264 PTP1B-IN-2 N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine ML213 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML418 ML188

VU0458298-2, VU0458298-3

ML277

(2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylphenyl)sulfonylpiperidine-2-carboxamide

(R)-N-(4-(4-Methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide

CID-53347902

ML277;ML 277; ML-277

(2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-[(4-methylphenyl) sulfonyl]-2-piperidinecarboxamide

(2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide

ML-277;ML 277;CID-53347902;CID53347902;CID 53347902

2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-, (2R)-

N-[4-(4-methoxy-phenyl)-thiazol-2-]-1-[1-(4-Methylbenzenesulfonyl) pip- eridine -2-] formamide

ML-277|||CID-53347902

ML277, 10 mM in DMSO

ML277 ，S0050

1401242-74-7

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