ML277
- Product Name
- ML277
- CAS No.
- 1401242-74-7
- Chemical Name
- ML277
- Synonyms
- ML277;CID-53347902;ML277;ML 277; ML-277;VU0458298-2, VU0458298-3;ML-277;ML 277;CID-53347902;CID53347902;CID 53347902;(R)-N-(4-(4-Methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide;(2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide;N-[4-(4-methoxy-phenyl)-thiazol-2-]-1-[1-(4-Methylbenzenesulfonyl) pip- eridine -2-] formamide;(2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylphenyl)sulfonylpiperidine-2-carboxamide;2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-, (2R)-
- CBNumber
- CB32715653
- Molecular Formula
- C23H25N3O4S2
- Formula Weight
- 471.59
- MOL File
- 1401242-74-7.mol
ML277 Property
- Density
- 1.341±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 5 mg/ml
- form
- powder
- pka
- 8.37±0.70(Predicted)
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML0524
- Product name
- ML277
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $129
- Updated
- 2023/06/20
- Product number
- SML0524
- Product name
- ML277
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $510
- Updated
- 2023/06/20
- Product number
- 15193
- Product name
- ML-277
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 15193
- Product name
- ML-277
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- 15193
- Product name
- ML-277
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $172
- Updated
- 2024/03/01
ML277 Chemical Properties,Usage,Production
Description
Potassium (K+) channels are categorized by their mode of activation and the number of transmembrane segments. The voltage-
Uses
ML277 has been used as the KCNQ1 activator to treat?cells in lung metastasis?assay.
Biochem/physiol Actions
ML277 is a potent activator of KCNQ1 (Kv7.1) channels with >100-fold selectivity versus KCNQ2 and KCNQ4 and no activity against the hERG potassium channel up to 30 μM. KCNQ1 is a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. Mutations in the KCNQ1 gene are associated with long QT syndrome (LQTS), a disorder in which the heart muscles take longer than normal to recover after each heart beat and can lead to dangerous arrhythmias such as atrial fibrillation. Activators of KCNQ1 channels could have potential use in treatments of LQTS. ML277 is the first selective and potent activator found, with an EC50 of 260 nM.
storage
Store at -20°C
ML277 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ML277 manufacturers
- Product
- (2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-[(4-methylphenyl) sulfonyl]-2-piperidinecarboxamide 1401242-74-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-01-01