K-Ras(G12C) inhibitor 9

Product Name: K-Ras(G12C) inhibitor 9
CAS No.: 1469337-91-4
Chemical Name: K-Ras(G12C) inhibitor 9
Synonyms: K-RAS inhibitor 9;K-Ras(G12C) inhibitor 9;K-Ras(GI2C) Inhibitor 9;K-Ras(G12C) inhibitor 9 USP/EP/BP;K RAS INHIBITOR-9; KRAS INHIBITOR 9;N-[1-[2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]-ethenesulfonamide;Ethenesulfonamide, N-[1-[2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]-;K-Ras(G-12C) inhibitor 9,KRas(G12C) inhibitor 9,Ras,Inhibitor,K-Ras(G12C) inhibitor 9,inhibit,K Ras(G12C) inhibitor 9
CBNumber: CB32722367
Molecular Formula: C16H21ClIN3O4S
Formula Weight: 513.78
MOL File: 1469337-91-4.mol

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K-Ras(G12C) inhibitor 9 Property

Boiling point:: 656.3±65.0 °C(Predicted)
Density: 1.68±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: crystalline solid
pka: 9.68±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18005
Product name: K-Ras(G12C) Inhibitor 9
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18005
Product name: K-Ras(G12C) Inhibitor 9
Purity: ≥98%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 18005
Product name: K-Ras(G12C) Inhibitor 9
Purity: ≥98%
Packaging: 10mg
Price: $341
Updated: 2024/03/01

Cayman Chemical

Product number: 18005
Product name: K-Ras(G12C) Inhibitor 9
Purity: ≥98%
Packaging: 25mg
Price: $533
Updated: 2024/03/01

TRC

Product number: C367445
Product name: N-[1-[2-[(4-Chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]ethenesulfonamide
Packaging: 5mg
Price: $185
Updated: 2021/12/16

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K-Ras(G12C) inhibitor 9 Chemical Properties,Usage,Production

Description

K-Ras(G12C) inhibitor 9 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 μM for 24 hours in vitro. K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis. Similar K-Ras(G12C) inhibitors significantly reduce GTP affinity relative to GDP, decrease Raf binding, and lower cell viability while increasing apoptosis.

Uses

N-[1-[2-[(4-Chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]ethenesulfonamide is an allosteric inhibitor of tumor-promoting K-Ras(G12c).

in vitro

k-ras(g12c) inhibitor 9 belongs to a series of small molecules, which irreversibly compete with gtp and gdp for binding to a common oncogenic k-ras(g12c) mutant and blocked the association of b-raf and c-raf with k-ras(g12c). k-ras(g12c) inhibitor 9 (10 μm) decreased viability and increased apoptosis of g12c mutations-containing lung cancer cell lines (h1792, calu-1, h358, and h23) [1].

target

k-ras(g12c)

References

1. ostrem jm, peters u, sos ml, wells ja, shokat km. k-ras(g12c) inhibitors allosterically control gtp affinity and effector interactions. nature. 2013;503(7477):548-51. 2. hunter jc, gurbani d, ficarro sb, carrasco ma, lim sm, choi hg, et al. in situ selectivity profiling and crystal structure of sml-8-73-1, an active site inhibitor of oncogenic k-ras g12c. proc natl acad sci u s a. 2014;111(24):8895-900. 3. lim sm, westover kd, ficarro sb, harrison ra, choi hg, pacold me, et al. therapeutic targeting of oncogenic k-ras by a covalent catalytic site inhibitor. angew chem int ed engl. 2014;53(1):199-204.

K-Ras(G12C) inhibitor 9 Preparation Products And Raw materials

Raw materials

Preparation Products

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K-Ras(G12C) inhibitor 9 Suppliers

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K-Ras(G12C) inhibitor 9

N-[1-[2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]-ethenesulfonamide

K RAS INHIBITOR-9; KRAS INHIBITOR 9

K-RAS inhibitor 9

Ethenesulfonamide, N-[1-[2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]-

K-Ras(G12C) inhibitor 9 USP/EP/BP

K-Ras(G-12C) inhibitor 9,KRas(G12C) inhibitor 9,Ras,Inhibitor,K-Ras(G12C) inhibitor 9,inhibit,K Ras(G12C) inhibitor 9

K-Ras(GI2C) Inhibitor 9

1469337-91-4

C16H21ClIN3O4S

Inhibitors