BOC-L-Proline

ChemicalBook > CAS DataBase List > BOC-L-Proline

Product Name: BOC-L-Proline
CAS No.: 15761-39-4
Chemical Name: BOC-L-Proline
Synonyms: BOC-PRO-OH;BOC-PRO;N-BOC-L-PROLINE;BOC-L-PRO;BOC-L-PRO-OH;N-(TERT-BUTOXYCARBONYL)-L-PROLINE;N-BOC-PROLINE;BOC-PROLINE;(S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid;(2S)-1-tert-butoxycarbonylpyrrolidine-2-carboxylic acid
CBNumber: CB3274189
Molecular Formula: C10H17NO4
Formula Weight: 215.25
MOL File: 15761-39-4.mol

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BOC-L-Proline Property

Melting point:: 133-135 °C(lit.)
alpha: -60.5 º (c=1, HAc)
Boiling point:: 355.52°C (rough estimate)
Density: 1.1835 (rough estimate)
refractive index: -60 ° (C=2, AcOH)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in acetic acid.
pka: 4.01±0.20(Predicted)
form: Crystals or Crystalline Powder
color: White
optical activity: [α]20/D 61±2°, c = 2% in acetic acid
BRN: 15828
InChIKey: ZQEBQGAAWMOMAI-ZETCQYMHSA-N
CAS DataBase Reference: 15761-39-4(CAS DataBase Reference)
EPA Substance Registry System: 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- (15761-39-4)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 24/25-36-26
WGK Germany: 3
TSCA: Yes
HS Code: 2933 99 80
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53003
Product name: Boc-Pro-OH
Purity: Novabiochem?
Packaging: 25g
Price: $56.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 15490
Product name: Boc-Pro-OH
Purity: ≥99.0% (T)
Packaging: 5g
Price: $36.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.53003
Product name: Boc-Pro-OH
Purity: Novabiochem?
Packaging: 100g
Price: $129
Updated: 2024/03/01

TCI Chemical

Product number: B1188
Product name: N-(tert-Butoxycarbonyl)-L-proline
Purity: >99.0%(T)
Packaging: 5g
Price: $20
Updated: 2024/03/01

TCI Chemical

Product number: B1188
Product name: N-(tert-Butoxycarbonyl)-L-proline
Purity: >99.0%(T)
Packaging: 25g
Price: $58
Updated: 2024/03/01

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BOC-L-Proline Chemical Properties,Usage,Production

Description

N-Boc-L-proline is a synthetic intermediate. It has been used in the synthesis of enantioselective catalysts for aldol reactions and hepatitis C virus (HCV) NS5A inhibitors.

Chemical Properties

White to off-white microcrystalline powder

Uses

N-Boc-L-proline is used as an intermediate in organic synthesis. It is also used to prepare daclatasvir, which inhibits the hepatitis C virus (HCV) non-structural 5A (NS5A) protein. Further, it is used as a drug in the treatment of hepatitis C virus (HCV).

Preparation

Triethylamine (16.5 mL, 0.12 mmol) was added dropwise over a period of 10 min to a stirred, ice-cold suspension of l-proline (10.0 g, 8.7 mmol) in dichloromethane (200 mL) in a 500-mL three-necked, round-bottomed flask. A solution of Boc2O (28.3 g, 0.13 mmol) in dichloromethane (100 mL) was then added over a period of 10 min and the mixture was stirred for 2.5 h. Thereafter, 10% aqueous citric acid (50 mL) was added, and the dichloromethane layer was washed with saturated brine (2×50 mL) and with water (50 mL). After drying the organic phase over magnesium sulfate, the solvent was evaporated and the residue was taken up in hot ethyl acetate. Dilution of this solution with hexane gave the product, N-tertbutoxycarbonyl- L-proline (17.8 g, 95%); mp 138–140℃; TLC (silica gel): Rf=0:36 (EtOAc/MeOH, 1:1).

BOC-L-Proline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BOC-L-Proline manufacturers

Henan Fengda Chemical Co., Ltd

Product: Boc-L-Proline 15761-39-4
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-13

WUHAN FORTUNA CHEMICAL CO., LTD

Product: BOC-L-Proline 15761-39-4
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kgs
Release date: 2021-08-27

Henan Bao Enluo International TradeCo.，LTD

Product: BOC-L-Proline 15761-39-4
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000tons
Release date: 2023-08-04

15761-39-4, BOC-L-ProlineRelated Search:

tert-Butyl peroxyacetate Fmoc-Lys(Boc)-OH Boc-Aib-OH Methyl acrylate Dimethyl succinate Diethylstilbestrol tert-Butanol N-Boc-L-valine L-Proline BUTYL OLEATE L-PROLINE-(4-3H(N)) cis-4-Hydroxy-L-proline Olibanum oil D-Proline Tris(trimethylsilyl)phosphate BOC-L-PROLINE AMIDE RAC 1-METHYL-PYRROLIDINE-2-CARBONITRILE CHLOROAC-PRO-OH

BOC-L-PROLINE-OH

BOC-L-PRO

L-Proline, N-BOC protected, (2S)-1-(tert-Butoxycarbonyl)pyrrolidine-2-carboxylic acid

L-PROLINE-N-T-BOC

BOC-L-Proline, 99+% 25GR

(S)-1-(tert-buto×ycarbonyl)pyrrolidine-2-carbo×ylic acid N-Boc-L-Proline

N-Boc-L-proline Boc-Pro-OH

N-(tert-Butoxycarbonyl)-L-proline

N-(tert-Butoxycarbonyl)-L-proline

(S)-Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

The BOC-L- pro

N-(tert-Butoxycarbonyl)-L-proline, 99.0%(T)

Boc-L-Proline SynonyMs N-(tert-Butoxycarbonyl)-L-proline

Boc-Pro-OH >=99.0% (T)

Daclatasvir Intermediates 3

Vildagliptin Impurity 15

1-tert-Butyloxycarbonyl-L-proline

(S)-Boc-pyrrolidine-2-carboxylic acid

Boc-L-proline≥ 98% (HPLC)

TBOC-L-PROLINE

T-BUTYLOXYCARBONYL-L-PROLINE

RARECHEM AL BO 1463

1,2-PYRROLIDINEDICARBOXYLIC ACID, 1-(1,1-DIMETHYLETHYL) ESTER, (2S)-

1-(tert-butyl) hydrogen (S)-pyrrolidine-1,2-dicarboxylate

BOC-L-Proline, 99+%

Boc-DL-Proline-OH

TERT-BUTYLOXYCARBONYLPROLINE

N-ALPHA-T-BUTYLOXYCARBONYL-L-PROLINE

N-BOC-PROLINE

(2S)-1-tert-butoxycarbonylpyrrolidine-2-carboxylic acid

Boc-Pro-OH (Boc-L-Proline

N-(tert-Butoxycarbonyl)-L-proline, Boc-L-proline

(2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

Butoxycarbonylproilne

N-(tert-Butoxycarbonyl)-L-proline ,98.5%

(2S)-1-(tert-Butyloxycarbonyl)pyrrolidine-2α-carboxylic acid

(2S)-1,2-Pyrrolidinedicarbonic acid 1-tert-butyl ester

(S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

Boc-Pro-OH (Boc-L-Proline: N-(tert-Butoxycarbonyl)-L-proline)

(2S)-Pyrrolidine-2-carboxylic acid, N-BOC protected

(S)-1,2-Pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) ester

N-(TERT-BUTOXYCARBONYL)-L-PROLINE

N-(TERT-BUTOXYCARBONYL)-L-PROILNE

N-(TERT-BUTYLOXYCARBONYL)-L-PROLINE

N-T-BUTOXYCARBONYL-L-PROLINE

N-T-BOC-L-PROLINE

N-BOC-L-PROLINE

n-alpha-tert-boc-l-proline

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-PROLINE

N-ALPHA-T-BUTOXYCARBONYL-L-PYRROLIDINE-2-CARBOXYLIC ACID

N-ALPHA-T-BUTOXYCARBONYL-L-PROLINE

N-ALPHA-T-BOC-L-PROLINE

BOC-L-PROLINE extrapure

1-Tert-Butoxycarbonyl-L-proline

Boc-L-proline ,98.5%

BOC-PYRD(2)-OH

BOC-PRO-OH

BOC-PRO