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BOC-L-Proline

Product Name
BOC-L-Proline
CAS No.
15761-39-4
Chemical Name
BOC-L-Proline
Synonyms
BOC-PRO-OH;BOC-PRO;N-BOC-L-PROLINE;BOC-L-PRO;BOC-L-PRO-OH;N-(TERT-BUTOXYCARBONYL)-L-PROLINE;N-BOC-PROLINE;BOC-PROLINE;(S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid;(2S)-1-tert-butoxycarbonylpyrrolidine-2-carboxylic acid
CBNumber
CB3274189
Molecular Formula
C10H17NO4
Formula Weight
215.25
MOL File
15761-39-4.mol
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BOC-L-Proline Property

Melting point:
133-135 °C(lit.)
alpha 
-60.5 º (c=1, HAc)
Boiling point:
355.52°C (rough estimate)
Density 
1.1835 (rough estimate)
refractive index 
-60 ° (C=2, AcOH)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in acetic acid.
pka
4.01±0.20(Predicted)
form 
Crystals or Crystalline Powder
color 
White
optical activity
[α]20/D 61±2°, c = 2% in acetic acid
BRN 
15828
InChIKey
ZQEBQGAAWMOMAI-ZETCQYMHSA-N
CAS DataBase Reference
15761-39-4(CAS DataBase Reference)
EPA Substance Registry System
1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- (15761-39-4)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
3
TSCA 
Yes
HS Code 
2933 99 80
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.53003
Product name
Boc-Pro-OH
Purity
Novabiochem?
Packaging
25g
Price
$56.1
Updated
2024/03/01
Sigma-Aldrich
Product number
15490
Product name
Boc-Pro-OH
Purity
≥99.0% (T)
Packaging
5g
Price
$36.4
Updated
2024/03/01
Sigma-Aldrich
Product number
8.53003
Product name
Boc-Pro-OH
Purity
Novabiochem?
Packaging
100g
Price
$129
Updated
2024/03/01
TCI Chemical
Product number
B1188
Product name
N-(tert-Butoxycarbonyl)-L-proline
Purity
>99.0%(T)
Packaging
5g
Price
$20
Updated
2024/03/01
TCI Chemical
Product number
B1188
Product name
N-(tert-Butoxycarbonyl)-L-proline
Purity
>99.0%(T)
Packaging
25g
Price
$58
Updated
2024/03/01
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BOC-L-Proline Chemical Properties,Usage,Production

Description

N-Boc-L-proline is a synthetic intermediate. It has been used in the synthesis of enantioselective catalysts for aldol reactions and hepatitis C virus (HCV) NS5A inhibitors.

Chemical Properties

White to off-white microcrystalline powder

Uses

N-Boc-L-proline is used as an intermediate in organic synthesis. It is also used to prepare daclatasvir, which inhibits the hepatitis C virus (HCV) non-structural 5A (NS5A) protein. Further, it is used as a drug in the treatment of hepatitis C virus (HCV).

Preparation

Triethylamine (16.5 mL, 0.12 mmol) was added dropwise over a period of 10 min to a stirred, ice-cold suspension of l-proline (10.0 g, 8.7 mmol) in dichloromethane (200 mL) in a 500-mL three-necked, round-bottomed flask. A solution of Boc2O (28.3 g, 0.13 mmol) in dichloromethane (100 mL) was then added over a period of 10 min and the mixture was stirred for 2.5 h. Thereafter, 10% aqueous citric acid (50 mL) was added, and the dichloromethane layer was washed with saturated brine (2×50 mL) and with water (50 mL). After drying the organic phase over magnesium sulfate, the solvent was evaporated and the residue was taken up in hot ethyl acetate. Dilution of this solution with hexane gave the product, N-tertbutoxycarbonyl- L-proline (17.8 g, 95%); mp 138–140℃; TLC (silica gel): Rf=0:36 (EtOAc/MeOH, 1:1).

BOC-L-Proline Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-L-Proline Suppliers

Americas 1 Belgium 1 Canada 2 China 481 Europe 3 France 4 Germany 9 Hungary 1 India 73 Japan 9 Russia 1 South Korea 1 Switzerland 6 United Kingdom 16 United States 86 USA 1 Global 695
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3576
Advantage
66
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View Lastest Price from BOC-L-Proline manufacturers

Henan Fengda Chemical Co., Ltd
Product
Boc-L-Proline 15761-39-4
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-13
WUHAN FORTUNA CHEMICAL CO., LTD
Product
BOC-L-Proline 15761-39-4
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
500kgs
Release date
2021-08-27
Henan Bao Enluo International TradeCo.，LTD
Product
BOC-L-Proline 15761-39-4
Price
US $100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000tons
Release date
2023-08-04

15761-39-4, BOC-L-ProlineRelated Search:

tert-Butyl peroxyacetate Fmoc-Lys(Boc)-OH Boc-Aib-OH Methyl acrylate Dimethyl succinate Diethylstilbestrol tert-Butanol N-Boc-L-valine L-Proline BUTYL OLEATE L-PROLINE-(4-3H(N)) cis-4-Hydroxy-L-proline Olibanum oil D-Proline Tris(trimethylsilyl)phosphate BOC-L-PROLINE AMIDE RAC 1-METHYL-PYRROLIDINE-2-CARBONITRILE CHLOROAC-PRO-OH

  • BOC-L-PROLINE-OH
  • BOC-L-PRO
  • L-Proline, N-BOC protected, (2S)-1-(tert-Butoxycarbonyl)pyrrolidine-2-carboxylic acid
  • L-PROLINE-N-T-BOC
  • BOC-L-Proline, 99+% 25GR
  • (S)-1-(tert-buto×ycarbonyl)pyrrolidine-2-carbo×ylic acid N-Boc-L-Proline
  • N-Boc-L-proline Boc-Pro-OH
  • <i>N</i>-(<i>tert</i>-Butoxycarbonyl)-L-proline
  • N-(<i>tert</i>-Butoxycarbonyl)-L-proline
  • (S)-Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester
  • The BOC-L- pro
  • N-(tert-Butoxycarbonyl)-L-proline, 99.0%(T)
  • Boc-L-Proline SynonyMs N-(tert-Butoxycarbonyl)-L-proline
  • Boc-Pro-OH >=99.0% (T)
  • Daclatasvir Intermediates 3
  • Vildagliptin Impurity 15
  • 1-tert-Butyloxycarbonyl-L-proline
  • (S)-Boc-pyrrolidine-2-carboxylic acid
  • Boc-L-proline≥ 98% (HPLC)
  • TBOC-L-PROLINE
  • T-BUTYLOXYCARBONYL-L-PROLINE
  • RARECHEM AL BO 1463
  • 1,2-PYRROLIDINEDICARBOXYLIC ACID, 1-(1,1-DIMETHYLETHYL) ESTER, (2S)-
  • 1-(tert-butyl) hydrogen (S)-pyrrolidine-1,2-dicarboxylate
  • BOC-L-Proline, 99+%
  • Boc-DL-Proline-OH
  • TERT-BUTYLOXYCARBONYLPROLINE
  • N-ALPHA-T-BUTYLOXYCARBONYL-L-PROLINE
  • N-BOC-PROLINE
  • (2S)-1-tert-butoxycarbonylpyrrolidine-2-carboxylic acid
  • Boc-Pro-OH (Boc-L-Proline
  • N-(tert-Butoxycarbonyl)-L-proline, Boc-L-proline
  • (2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
  • Butoxycarbonylproilne
  • N-(tert-Butoxycarbonyl)-L-proline ,98.5%
  • (2S)-1-(tert-Butyloxycarbonyl)pyrrolidine-2α-carboxylic acid
  • (2S)-1,2-Pyrrolidinedicarbonic acid 1-tert-butyl ester
  • (S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid
  • Boc-Pro-OH (Boc-L-Proline: N-(tert-Butoxycarbonyl)-L-proline)
  • (2S)-Pyrrolidine-2-carboxylic acid, N-BOC protected
  • (S)-1,2-Pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) ester
  • N-(TERT-BUTOXYCARBONYL)-L-PROLINE
  • N-(TERT-BUTOXYCARBONYL)-L-PROILNE
  • N-(TERT-BUTYLOXYCARBONYL)-L-PROLINE
  • N-T-BUTOXYCARBONYL-L-PROLINE
  • N-T-BOC-L-PROLINE
  • N-BOC-L-PROLINE
  • n-alpha-tert-boc-l-proline
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-L-PROLINE
  • N-ALPHA-T-BUTOXYCARBONYL-L-PYRROLIDINE-2-CARBOXYLIC ACID
  • N-ALPHA-T-BUTOXYCARBONYL-L-PROLINE
  • N-ALPHA-T-BOC-L-PROLINE
  • BOC-L-PROLINE extrapure
  • 1-Tert-Butoxycarbonyl-L-proline
  • Boc-L-proline ,98.5%
  • BOC-PYRD(2)-OH
  • BOC-PRO-OH
  • BOC-PRO