METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE

Product Name: METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE
CAS No.: 78471-43-9
Chemical Name: METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE
Synonyms: 4-BroMo-2-broMoMethyl-benzoic acid Methyl ester;Methyl 2-bromomethyl-4-bromobenzoate;METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE;Methyl4-bromo-2-(bromomethyl)benzoate,96%;1-(4-BROMO-2-(BROMOMETHYL)PHENYL)ETHANONE;Benzoic acid, 4-broMo-2-(broMoMethyl)-, Methyl ester
CBNumber: CB3276633
Molecular Formula: C9H8Br2O2
Formula Weight: 307.97
MOL File: 78471-43-9.mol

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METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE Property

Melting point:: 76-78℃
Boiling point:: 364.3±32.0 °C(Predicted)
Density: 1.780±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to crystal
color: White to Light yellow to Light orange
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C9H8Br2O2/c1-13-9(12)8-3-2-7(11)4-6(8)5-10/h2-4H,5H2,1H3
InChIKey: SGFACFBLUAWICV-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=C(Br)C=C1CBr

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Safety

RIDADR: UN 3261 8/PG III
HazardClass: 8
PackingGroup: III
HS Code: 2916310090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2941
Product name: Methyl 4-Bromo-2-(bromomethyl)benzoate
Purity: >97.0%(GC)
Packaging: 200mg
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: M2941
Product name: Methyl 4-Bromo-2-(bromomethyl)benzoate
Purity: >97.0%(GC)
Packaging: 1g
Price: $155
Updated: 2025/07/31

TRC

Product number: M295948
Product name: Methyl 4-Bromo-2-(bromomethyl)benzoate
Packaging: 500mg
Price: $70
Updated: 2021/12/16

TRC

Product number: M295948
Product name: Methyl 4-Bromo-2-(bromomethyl)benzoate
Packaging: 250mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR400314
Product name: Methyl 4-Bromo-2-(bromomethyl)benzoate
Packaging: 1g
Price: $53
Updated: 2021/12/16

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METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE Chemical Properties,Usage,Production

Uses

Methyl 4-bromo-2-(bromomethyl)benzoate is used as pharmaceutical intermediate.

Synthesis

99548-55-7

78471-43-9

General procedure for the synthesis of methyl 4-bromo-2-bromomethylbenzoate from methyl 4-bromo-2-methylbenzoate: a mixture of methyl 4-bromo-2-methylbenzoate (1 g, 4.4 mmol), N-bromosuccinimide (NBS, 0.80 g, 4.4 mmol), benzoyl peroxide (BPO, 56 mg, 0.23 mmol) and carbon tetrachloride (CCl4 , 20 mL) mixture was stirred and reacted at 85°C for 2 hours. Upon completion of the reaction, the mixture was filtered through a silica gel pad and the filtrate was subsequently concentrated to afford the target product methyl 4-bromo-2-bromomethylbenzoate (1.3 g, 97% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 6, p. 1324 - 1328
[2] Patent: WO2018/68017, 2018, A1. Location in patent: Page/Page column 126
[3] Patent: WO2007/339, 2007, A1. Location in patent: Page/Page column 35-36
[4] Patent: US2010/222363, 2010, A1. Location in patent: Page/Page column 13
[5] Patent: WO2007/337, 2007, A1. Location in patent: Page/Page column 30

METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE Suppliers

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View Lastest Price from METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE manufacturers

Shanghai Rlavie Technology Co ltd

Product: Methyl 2-bromomethyl-4-bromobenzoate 78471-43-9
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: 500kgs/month
Release date: 2021-11-20

Career Henan Chemical Co

Product: METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE 78471-43-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KGS
Release date: 2020-01-08

78471-43-9, METHYL 4-BROMO-2-BROMOMETHYL-BENZOATERelated Search:

METHYL 4-CHLORO-3-METHYLBENZOATE METHYL 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZOATE METHYL 4-(TRIFLUOROMETHYL)NICOTINATE METHYL 4-AMINO-6-INDOLECARBOXYLATE 2-(BROMOMETHYL)BENZYL ALCOHOL, 95% BENZOIC ACID,4-BROMO-2-METHYL-,METHYL ESTER 2-(Bromomethyl)benzoic acid METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE Methyl 2-bromomethylbenzoate

METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE

Benzoic acid, 4-broMo-2-(broMoMethyl)-, Methyl ester

Methyl 2-bromomethyl-4-bromobenzoate

1-(4-BROMO-2-(BROMOMETHYL)PHENYL)ETHANONE

4-BroMo-2-broMoMethyl-benzoic acid Methyl ester

Methyl4-bromo-2-(bromomethyl)benzoate,96%

78471-43-9