Necitumumab
- Product Name
- Necitumumab
- CAS No.
- 906805-06-9
- Chemical Name
- Necitumumab
- Synonyms
- Necitumumab;IMC-11F8/LY301221;Necitumumab (anti-EGFR);Research Grade Necitumumab;Research Grade Necitumumab(DHB86901)
- CBNumber
- CB33044071
- Formula Weight
- 0
- MOL File
- Mol file
Necitumumab Property
- form
- Liquid
- color
- Colorless to light yellow
Necitumumab Chemical Properties,Usage,Production
Uses
Necitumumab is a human IgG monoclonal antibody directed against EGFR. Necitumumab can be used for research of NSCLC, colorectal cancer, etc[1].
Clinical Use
IgG1 monoclonal antibody:
Treatment of locally advanced or metastatic
epidermal growth factor receptor (EGFR) expressing
squamous non-small cell lung cancer
Drug interactions
Potentially hazardous interactions with other drugs
Live vaccines: avoid concomitant use.
Metabolism
The elimination routes of necitumumab are only partially documented, and involve degradation to peptides after being internalised into its target cells, proteolysis within the liver or the reticuloendothelial system, as well as nonspecific endocytosis.
References
[1] Garnock-Jones KP. Necitumumab: First Global Approval. Drugs. 2016 Feb;76(2):283-9. DOI:10.1007/s40265-015-0537-0
Necitumumab Preparation Products And Raw materials
Raw materials
Preparation Products
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