ChemicalBook > CAS DataBase List > Hydroxy-PEG3-t-butylester

Hydroxy-PEG3-t-butylester

Product Name: Hydroxy-PEG3-t-butylester
CAS No.: 133803-81-3
Chemical Name: Hydroxy-PEG3-t-butylester
Synonyms: TERT-BUTYL 3-(2-(2-HYDROXYETHOXY)ETHOXY)PROPANOATE;HO-PEG2-CH2CH2COOtBu;OH-PEG2-TBA;HO-PEG2-COOtBu;OH-PEG2-CH2CH2COOtBu;HO-PEG2-t-Butyl ester;Hydroxy-PEG2-(CH2)2-Boc;Hydroxy-PEG3-t-butylester;Hydroxy-PEG2-t-butyl ester;tert-Butyl PEG2 propanoate
CBNumber: CB33048721
Molecular Formula: C11H22O5
Formula Weight: 234.29
MOL File: 133803-81-3.mol

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Hydroxy-PEG3-t-butylester Property

Boiling point:: 321.8±22.0 °C(Predicted)
Density: 1.046±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in DMSO
form: clear liquid
pka: 14.36±0.10(Predicted)
color: Colorless to Almost colorless
InChI: InChI=1S/C11H22O5/c1-11(2,3)16-10(13)4-6-14-8-9-15-7-5-12/h12H,4-9H2,1-3H3
InChIKey: OKOWESVURLUVMD-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)CCOCCOCCO

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Safety

HS Code: 2918999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: P2719
Product name: PEG3-carboxylic Acid tert-Butyl Ester
Packaging: 1G
Price: $50
Updated: 2025/07/31

TCI Chemical

Product number: P2719
Product name: PEG3-carboxylic Acid tert-Butyl Ester
Packaging: 5G
Price: $245
Updated: 2025/07/31

TRC

Product number: H953233
Product name: Hydroxy-PEG2-t-butylEster
Packaging: 500mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-0058621
Product name: Hydroxy-PEG2-(CH2)2-Boc
Purity: ≥97.0%
Packaging: 1g
Price: $63
Updated: 2021/12/16

AK Scientific

Product number: J93586
Product name: Hydroxy-PEG2-t-butylester
Packaging: 1g
Price: $65
Updated: 2021/12/16

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Hydroxy-PEG3-t-butylester Chemical Properties,Usage,Production

Description

Hydroxy-PEG2-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Hydroxy-PEG2-(CH2)2-Boc is an ADC linker for the synthesis of antibody drug conjugates (ADC), Hydroxy-PEG2-(CH2)2-Boc is derived from patent WO2004008101A2 (compound 196). Hydroxy-PEG2-(CH2)2-Boc can also be used as a PROTAC linker for PROTAC synthesis.

Synthesis

1663-39-4

111-46-6

133803-81-3

Example 1: Synthesis of tert-butyl 3-(2-(2-hydroxyethoxy)ethoxy)propionate (84) In 350 mL of anhydrous tetrahydrofuran (THF), 80 mg (0.0025 mol) of sodium metal and diethylene glycol (150.1 g, 1.41 mol) were added and stirred until the sodium metal was completely dissolved. Subsequently, tert-butyl acrylate (24 mL, 0.33 mol) was added. The reaction mixture was stirred at room temperature for 20 h. After completion of the reaction, it was neutralized with 8 mL of 1.0 M hydrochloric acid (HCl). The solvent was removed by distillation under reduced pressure and the residue was suspended in 250 mL of brine and extracted with ethyl acetate (3 x 125 mL). The organic layers were combined, washed sequentially with 100 mL of brine and 100 mL of water, dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure. The resulting colorless oil was dried under vacuum to give 60.27 g (78% yield) of the target product 84. Product Characterization: 1H NMR (CDCl3): δ 1.41 (s, 9H), 2.49 (t, 2H, J = 6.4 Hz), 3.59-3.72 (m, 10H). ESI MS m/z: [M-H]- calcd for C11H21O5, 233.15; found, 233.40.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

IC 50

Non-cleavable Linker; PEGs; Alkyl/ether

References

[1] Synthesis (Germany), 2014, vol. 46, # 10, p. 1399 - 1406
[2] Patent: WO2015/155753, 2015, A2. Location in patent: Page/Page column 84
[3] Journal of the American Chemical Society, 2011, vol. 133, # 10, p. 3230 - 3233
[4] Synthetic Communications, 2004, vol. 34, # 13, p. 2425 - 2432
[5] Patent: WO2018/2902, 2018, A1. Location in patent: Page/Page column 46

Hydroxy-PEG3-t-butylester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Hydroxy-PEG3-t-butylester manufacturers

LAURENT

Product: HO-PEG2-CH2CH2COOtBu 133803-81-3
Price: US $11.97/g
Min. Order: 10g
Purity: 98%
Supply Ability: 200kg
Release date: 2025-11-17

Xian confluore Biological Technology Co., Ltd.

Product: Hydroxy-PEG2-t-butyl ester 133803-81-3
Price: US $0.00/g
Min. Order: 25g
Purity: >98.00%
Supply Ability: 25g
Release date: 2024-03-25

Career Henan Chemical Co

Product: tert-butyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate 133803-81-3
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-09

133803-81-3, Hydroxy-PEG3-t-butylesterRelated Search:

Hydroxy-PEG8-ethyl ester OH-PEG9-CH2-COOMe 3-[2-(2-Hydroxyethoxy)ethoxy]propanoic acid PEG4-acid HO-PEG6-CH2CH2COOH α,ω-dipropionic acid tetraethylene glycol Bis-PEG6-acid alpha-[3-(1,1-Dimethylethoxy)-3-oxopropyl]-omega-hydroxypoly(oxy-1,2-ethanediyl) HO-PEG8-CH2CH2COOH Hydroxy-PEG5-acid PEG5-acid PEG7-t-butly ester PEG9-t-butly ester HO-PEG10-tBu Hydroxy-PEG4-t-butyl ester Hydroxy-PEG9-t-butyl ester TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- HO-PEG5-tBu

Hydroxy-PEG3-t-butylester

HO-PEG2-CH2CH2COOtBu

OH-PEG2-CH2CH2COOtBu

OH-PEG2-TBA

HO-PEG2-t-Butyl ester

Hydroxy-PEG2-t-butyl ester

TERT-BUTYL 3-(2-(2-HYDROXYETHOXY)ETHOXY)PROPANOATE

Propanoic acid, 3-[2-(2-hydroxyethoxy)ethoxy]-, 1,1-dimethylethyl ester

tert-Butyl 9-Hydroxy-4,7-dioxanonanoate

HO-PEG2-COOtBu

Hydroxy-PEG2-(CH2)2-Boc

PEG3-carboxylic Acid tert-Butyl Ester

tert-Butyl PEG2 propanoate

3-[2-(2-Hydroxyethoxy)ethoxy]propanoic Acid tert-Butyl Ester

9-Hydroxy-4,7-dioxanonanoic Acid tert-Butyl Ester

HO-(CH2CH2O)2-CH2CH2COOt-Bu

HO-PEG2-CH2CH2COOtBu/Propanoic acid, 3-[2-(2-hydroxyethoxy)ethoxy]-, 1,1-dimethylethyl ester

<i>tert</i>-Butyl 3-(2-(2-hydroxyethoxy)ethoxy)propanoate

133803-81-3

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