ChemicalBook > CAS DataBase List > ML 18

ML 18

Product Name
ML 18
CAS No.
1422269-30-4
Chemical Name
ML 18
Synonyms
ML 18;ML18, >98%;BRS-3 antagonist;ML-18, 10 mM in DMSO;ML18;ML-18;ML 18;BRS-3 ANTAGONIST;1422269-30-4;Bombesin Receptor,ML-18,ML 18,inhibit,Inhibitor,ML18;(S)-3-(1H-Indol-3-yl)-N-((1-(4-methoxyphenyl)cyclohexyl)methyl)-2-(3-(4-nitrophenyl)ureido)propanamide;(2S)-3-(1H-INDOL-3-YL)-N-{[1-(4-METHOXYPHENYL)CYCLOHEXYL]METHYL}-2-{[(4-NITROPHENYL)CARBAMOYL]AMINO}PROPANAMIDE
CBNumber
CB33170389
Molecular Formula
C32H35N5O5
Formula Weight
569.66
MOL File
1422269-30-4.mol
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ML 18 Property

Boiling point:
821.8±65.0 °C(Predicted)
Density 
1.291±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble
form 
A solid
pka
11.99±0.46(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27319
Product name
ML-18
Packaging
500μg
Price
$35
Updated
2024/03/01
Cayman Chemical
Product number
27319
Product name
ML-18
Packaging
1mg
Price
$67
Updated
2024/03/01
Cayman Chemical
Product number
27319
Product name
ML-18
Packaging
5mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
27319
Product name
ML-18
Packaging
10mg
Price
$315
Updated
2024/03/01
TRC
Product number
M425185
Product name
ML18
Packaging
1mg
Price
$90
Updated
2021/12/16
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ML 18 Chemical Properties,Usage,Production

Description

ML-18 is a non-peptide bombesin receptor subtype 3 (BB3) antagonist that inhibits [125I]BA1 binding to NCI-H1299 lung cancer cells transfected with human BB3 receptors (IC50 = 4.8 μM). It is selective for BB3 over the gastrin releasing peptide receptor (GRPR) and the neuromedin B receptor (NMBR) with IC50 values of 16 and >100 μM, respectively, in a radioligand binding assay. ML-18 (16 μM) reversibly inhibits BA1-induced increases in cytosolic calcium in NCI-H1299 cells. It also inhibits BA1-induced phosphorylation of ERK and EGFR and reduces proliferation of NCI-H1299 cells.

Uses

ML-18 is a non-peptide bombesin receptor subtype-3 antagonist. It also inhibits lung cancer growth.

References

[1] TERRY W. MOODY . ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth[J]. Peptides, 2015, 64: Pages 55-61. DOI: 10.1016/j.peptides.2014.12.005

ML 18 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML 18 Suppliers

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1422269-30-4, ML 18Related Search:

ML346 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one ML-228 ML188 (Racemate) ML-098 ML277 ML 204 ML329 ML364 VU0456810 ML188 ML418 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML213 N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine ML-327 PTP1B-IN-2 ML264

  • BRS-3 antagonist
  • ML18;ML-18;ML 18;BRS-3 ANTAGONIST;1422269-30-4
  • ML18, >98%
  • ML 18
  • (2S)-3-(1H-INDOL-3-YL)-N-{[1-(4-METHOXYPHENYL)CYCLOHEXYL]METHYL}-2-{[(4-NITROPHENYL)CARBAMOYL]AMINO}PROPANAMIDE
  • (S)-3-(1H-Indol-3-yl)-N-((1-(4-methoxyphenyl)cyclohexyl)methyl)-2-(3-(4-nitrophenyl)ureido)propanamide
  • Bombesin Receptor,ML-18,ML 18,inhibit,Inhibitor,ML18
  • ML-18, 10 mM in DMSO
  • 1422269-30-4