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BAY-1895344

Product Name
BAY-1895344
CAS No.
1876467-74-1
Chemical Name
BAY-1895344
Synonyms
Elimusertib;CPD1213;BAY-1895344;BAY-1895344 diHCl;Elimusertib free base;Elimusertib (BAY1895344);BAY 1895344 (BAY-1895344);Elimusertib, 10 mM in DMSO;BAY-1895344 HCl(Elimusertib);BAY1895344;BAY 1895344;CPD1213
CBNumber
CB33175465
Molecular Formula
C20H21N7O
Formula Weight
375.43
MOL File
1876467-74-1.mol
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BAY-1895344 Property

Melting point:
>200°C (dec.)
Boiling point:
661.1±55.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
11.09±0.10(Predicted)
form 
Solid
color 
Orange
InChI
InChI=1S/C20H21N7O/c1-13-12-28-10-9-27(13)18-11-15(17-5-8-23-26(17)2)14-3-6-21-20(19(14)24-18)16-4-7-22-25-16/h3-8,11,13H,9-10,12H2,1-2H3,(H,22,25)/t13-/m1/s1
InChIKey
YBXRSCXGRPSTMW-CYBMUJFWSA-N
SMILES
N1C2C(=CC=NC=2C2C=CNN=2)C(C2N(C)N=CC=2)=CC=1N1CCOC[C@H]1C
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B118925
Product name
BAY-1895344
Packaging
5mg
Price
$165
Updated
2021/12/16
Axon Medchem
Product number
Axon2918
Product name
BAY1895344
Purity
99%
Packaging
2x5mg
Price
$176
Updated
2021/12/16
ChemScene
Product number
CS-0021722
Product name
Elimusertib
Purity
99.91%
Packaging
5mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-0021722
Product name
Elimusertib
Purity
99.91%
Packaging
25mg
Price
$390
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0005697
Product name
BAY-1895344
Purity
95.00%
Packaging
5MG
Price
$450.43
Updated
2021/12/16
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BAY-1895344 Chemical Properties,Usage,Production

Uses

BAY-1895344 is a selective ATR (ataxia-telangiectasia and Rad3 related protein) inhibitor used in the treatment of advanced hyperproliferative disease, prophylaxis, solid tumors and lymphomas.

in vivo

Elimusertib shows potent anti-tumor efficacy in monotherapy in a variety of xenograft models of ovarian and colorectal cancer, and causes complete tumor remission in mantle cell lymphoma models[2].
Elimusertib (50 mg/kg; p.o.; b.i.d.; 3 days on/4 days off; for 11 days) exhibits strong antitumor efficacy in the ATM-mutated SU-DHL-8 (ATM K1964E) human GCB-DLBCL cell line derived xenograft model in mice[3].
Elimusertib (20 mg/kg, and 10 mg/kg from day 14; p.o.; daily; 2 days on/5 days off; for 42 days) in combination with Carboplatin (40 mg/kg; i.p.; daily; 1 day on/6 days off) results in synergistic antitumor activity in the platinum-resistant ATM protein low expressing CR5038 human CRC PDX model in NOD/SCID mice[3].
Elimusertib exhibits moderate oral bioavailability (rat 87%, dog 51%) following oral administration (rat and dog 0.6-1 mg/kg)[3].
Elimusertib exhibits terminal elimination half-lives (mouse 0.17 h, rat 1.3 and, dog 1.0 h) due to plasma clearance (3.5, 1.2, and 0.79 L/h/kg respectively) following intravenous administration (mouse, rat and dog 0.3-0.5 mg/kg)[3].

Animal Model:Female C.B-17 SCID mice, SU-DHL-8 GCB-DLBCL xenograft model[3]
Dosage:50 mg/kg
Administration:Oral administration, b.i.d., 3 days on/4 days off, for 11 days
Result:Inhibited tumor area.
Animal Model:Male Wistar rats[3]
Dosage:0.3-0.5 mg/kg for i.v.; 0.6-1 mg/kg for oral (Pharmacokinetic Analysis)
Administration:Intravenous injection and oral administration
Result:Oral bioavailability (87%), T1/2 (1.3 h).
Animal Model:Female beagle dogs[3]
Dosage:0.3-0.5 mg/kg for i.v.; 0.6-1 mg/kg for oral (Pharmacokinetic Analysis)
Administration:Intravenous injection and oral administration
Result:Oral bioavailability (51%), T1/2 (1.0 h).

IC 50

ATR: 7 nM (IC50)

BAY-1895344 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY-1895344 Suppliers

China 103 India 1 United States 8 Global 112
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58

1876467-74-1, BAY-1895344Related Search:

BAY1895344 2HCl BAY-2402234 BAY-1125976. BAY-885 BAY-985 BAY 1316957) BAY-1163877 BAY1895344 HCl Benzamide, N-[5-(3,5-dicyano-1,4-dihydro-1,2,6-trimethyl-4-pyridinyl)-6-fluoro-7-methyl-1H-indazol-3-yl]-2-ethyl- BAY 2666605 BAY 2416964

  • BAY-1895344
  • CPD1213
  • (R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-1,7-naphthyridin-2-yl)morpholine
  • BAY1895344;BAY 1895344;CPD1213
  • BAY1895344;BAY 1895344;BAY-1895344
  • 1,7-Naphthyridine, 2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-
  • Elimusertib
  • BAY-1895344 HCl(Elimusertib)
  • Elimusertib free base
  • (R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine
  • Elimusertib (BAY1895344)
  • BAY-1895344 diHCl
  • BAY 1895344 (BAY-1895344)
  • (R)-3-Methyl-4-[4-(1-methyl-5-pyrazolyl)-8-(5-pyrazolyl)-1,7-naphthyridin-2-yl]morpholine
  • (R)-3-Methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-1,7-naphthyridin-2-yl)morpholine , Elimusertib
  • Elimusertib, 10 mM in DMSO
  • 3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-1,7-naphthyridin-2-yl)morpholine
  • 1876467-74-1
  • API