ChemicalBook > CAS DataBase List > 4-(Trifluoromethoxy)aniline

4-(Trifluoromethoxy)aniline

Product Name
4-(Trifluoromethoxy)aniline
CAS No.
461-82-5
Chemical Name
4-(Trifluoromethoxy)aniline
Synonyms
Riluzole Related CoMpound A;AKOS B016000;4-(TrifluoroMe;Riluzole USP RC A;TIMTEC-BB SBB001667;Riluzole Impurity 10;Trifluoromethoxyaniline;4-Trifluoroethoxyaniline;4-trifluoromethoxyaniune;4-(Trifluormethoxy)anilin
CBNumber
CB3322028
Molecular Formula
C7H6F3NO
Formula Weight
177.12
MOL File
461-82-5.mol
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4-(Trifluoromethoxy)aniline Property

Boiling point:
73-75 °C10 mm Hg(lit.)
Density 
1.32 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.463(lit.)
Flash point:
177 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka
3.75±0.10(Predicted)
form 
Liquid
color 
Clear colorless to yellow
Specific Gravity
1.310
BRN 
2090209
Stability:
Hygroscopic
InChI
InChI=1S/C7H6F3NO/c8-7(9,10)12-6-3-1-5(11)2-4-6/h1-4H,11H2
InChIKey
XUJFOSLZQITUOI-UHFFFAOYSA-N
SMILES
C1(N)=CC=C(OC(F)(F)F)C=C1
CAS DataBase Reference
461-82-5(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xi,Xn
Risk Statements 
24/25-33-38-41-36/37/38-20/21/22
Safety Statements 
26-36/37/39-45-36
RIDADR 
UN 2941 6.1/PG 3
WGK Germany 
2
Hazard Note 
Toxic
HazardClass 
IRRITANT, TOXIC
HazardClass 
6.1
PackingGroup 
III
HS Code 
29222900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H310Fatal in contact with skin

H315Causes skin irritation

H318Causes serious eye damage

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
337056
Product name
4-(Trifluoromethoxy)aniline
Purity
98%
Packaging
5g
Price
$46.8
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR3132
Product name
Riluzole Related Compound A
Purity
pharmaceutical secondary standard, certified reference material
Packaging
50MG
Price
$534
Updated
2024/03/01
Sigma-Aldrich
Product number
1604348
Product name
Riluzole Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1210
Updated
2024/03/01
TCI Chemical
Product number
T1345
Product name
4-(Trifluoromethoxy)aniline
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$20
Updated
2024/03/01
TCI Chemical
Product number
T1345
Product name
4-(Trifluoromethoxy)aniline
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$55
Updated
2024/03/01
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4-(Trifluoromethoxy)aniline Chemical Properties,Usage,Production

Chemical Properties

CLEAR YELLOW LIQUID

Uses

4-(Trifluoromethoxy)aniline was used in the synthesis of:

  • side-group liquid-crystalline polymethacrylates with fluorine-containing mesogens
  • derivatives of 3-(quinolin-3-yl)acrylates
  • series of novel Shiff bases, via condensation with pyridinecarboxaldehydes in the presence of molecular sieves

Uses

4-(Trifluoromethoxy)aniline is used in the synthesis of anticancer agents and antitumor medicaments. Also, its an intermediate in the production of labelled Riluzole, a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant.

4-(Trifluoromethoxy)aniline Preparation Products And Raw materials

Raw materials

4-(TRIFLUOROMETHOXY)BENZAMIDE 4-(Trifluoromethoxy)nitrobenzene Potassium hydroxide

Preparation Products

Triflumuron Riluzole 5-[4-(TRIFLUOROMETHOXY)PHENYL]-2-FURALDEHYDE
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View Lastest Price from 4-(Trifluoromethoxy)aniline manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
4-(Trifluoromethoxy)aniline 461-82-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-07-31
Hebei Mujin Biotechnology Co.,Ltd
Product
4-(Trifluoromethoxy)aniline 461-82-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-11-01
Hebei Weibang Biotechnology Co., Ltd
Product
4-(Trifluoromethoxy)aniline 461-82-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-08

461-82-5, 4-(Trifluoromethoxy)anilineRelated Search:

4-Methoxyphenylacetone 4'-(Trifluoromethoxy)acetophenone o-Anisaldehyde Anisole (Trifluoromethoxy)benzene 3-Methoxybenzaldehyde 4-(Trifluoromethoxy)chlorobenzene 2-(Trifluoromethoxy)aniline 4-Aminobenzotrifluoride (3-Methoxyphenyl)acetonitrile 4-Methoxyphenylacetic acid 4-Methoxybenzylchloride p-Trifluoromethoxy phenol 3-(Trifluoromethoxy)aniline Trimethyl phosphite 2-Fluoroaniline Aniline 4-Fluoroaniline

  • Riluzole Related Compound A (25 mg) (4-trifluoromethoxyaniline)
  • 4-(TrifluoroMethoxy)aniline, 99+% 2.5GR
  • Riluzole Related CoMpound A
  • For trifluoromethoxy aniline
  • 4- threedifluoro Methoxyaniline
  • 4-TrifluoroMethoxyaniline, 97+%
  • The trifluoro Methoxy aniline
  • 4-(TrifluoroMe
  • 4-(Trifluormethoxy)anilin
  • 4-(TRIFLUOROMETHOXY)ANILINE 99.5+%
  • 4-(trifluoromethoxy)aniline,2-(trifluoromethoxy)benzenamine
  • Benzenamine, 4-(trifluoromethoxy)-
  • 4-(Trifluoromethoxy)aniline,α,α,α-Trifluoro-p-anisidine
  • AMino TrifluoroMethoxybenzene
  • 4-Amino-alpha,alpha,alpha-trifluoroanisole
  • 4-Trifluoronethoxyaniline
  • Riluzole USP Related Compound A
  • Riluzole Impurity 10
  • ALPHA,ALPHA,ALPHA-TRIFLUORO-P-ANISIDINE
  • AKOS B016000
  • 4-(TRIFLUOROMETHOXY)ANILINE
  • 4-TRIFLUOROMETHOXY-PHENYLAMINE
  • TIMTEC-BB SBB001667
  • 4-Trifluoroethoxyaniline
  • 4-trifluoromethoxyaniune
  • p-Trifluoromethoxyaniline
  • p-Aminotrifluoromethoxybenzene
  • P-Aminotrifluoromethpxybenzene
  • 4-Aminotrifluoromethoxybenzene
  • 4-(Trifluoromethoxy)aniline, 99+%
  • 4-TRIFLUORO METHOXYLAMINE
  • α,α,α-trifluoro-p-anisidine
  • 4-(Trifluoromethoxy)aniline 98%
  • 4-(Trifluoromethoxy)aniline98%
  • 4-(Trifluoromethoxy)aminobenzene
  • 4-(trifluoromethoxy)benzenaime
  • Riluzole USP RC A
  • Trifluoromethoxyaniline
  • 4-(Trifluomethoxy) Aniline
  • Riluzole Related Compound A (4-trifluoromethoxyaniline) (1604348)
  • 461-82-5
  • 462-28-5
  • 117528-59-4
  • C7H5F3NO
  • CF3OC6H4NH2
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