ChemicalBook > CAS DataBase List > 2,4-Dichloro-5-thiazolecarboxaldehyde
2,4-Dichloro-5-thiazolecarboxaldehyde
- Product Name
- 2,4-Dichloro-5-thiazolecarboxaldehyde
- CAS No.
- 92972-48-0
- Chemical Name
- 2,4-Dichloro-5-thiazolecarboxaldehyde
- Synonyms
- e-5-carbaL;oro-1,3-thiazoL;BUTTPARK 121\04-87;IFLAB-BB F2124-0686;2,4-DICHLORO-5-FORMYLTHIAZOLE;2,4-Dichloro-5-formyl-1,3-thiazole;2,4-DICHLOROTHIAZOLE-5-CARBALDEHYDE;2,4-Dichloro-thiazol-5-carbaldehyde;2,4-DICHLOROTHIAZOL-5-CARBOXALDEHYDE;2,4-DICHLORO-5-THIAZOLECARBOXALDEHYDE
- CBNumber
- CB3328000
- Molecular Formula
- C4HCl2NOS
- Formula Weight
- 182.03
- MOL File
- 92972-48-0.mol
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2,4-Dichloro-5-thiazolecarboxaldehyde Property
- Melting point:
- 47-53℃
- Boiling point:
- 307.1±45.0 °C(Predicted)
- Density
- 1.690±0.06 g/cm3(Predicted)
- Flash point:
- >110°C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- -3.71±0.10(Predicted)
- color
- Pale Beige
- CAS DataBase Reference
- 92972-48-0(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-36-22
- Safety Statements
- 26-36/37/39
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 6.1
- HS Code
- 29341000
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 724300
- Product name
- 2,4-Dichlorothiazole-5-carboxaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $75.7
- Updated
- 2023/06/20
TRC
- Product number
- D435925
- Product name
- 2,4-Dichloro-5-thiazolecarboxaldehyde
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
TRC
- Product number
- D435925
- Product name
- 2,4-Dichloro-5-thiazolecarboxaldehyde
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
TRC
- Product number
- D435925
- Product name
- 2,4-Dichloro-5-thiazolecarboxaldehyde
- Packaging
- 5g
- Price
- $150
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 069588
- Product name
- 2,4-Dichloro-5-formylthiazole
- Purity
- 97%
- Packaging
- 5g
- Price
- $163
- Updated
- 2021/12/16
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2,4-Dichloro-5-thiazolecarboxaldehyde Chemical Properties,Usage,Production
Uses
2,4-Dichloro-5-thiazolecarboxaldehyde is used in the synthesis of some novel thiazolidine-2,4-dione derivatives having antimicrobial activity.
Synthesis
2295-31-0
68-12-2
92972-48-0
General procedure for the synthesis of 2,4-dichlorothiazole-5-carboxaldehyde (330): 2,4-thiazolidinedione (329, 2.7 g, 23.07 mmol) was dissolved in N,N-dimethylformamide (DMF, 1.23 mL, 15.98 mmol) at 0 °C and protected by argon and slowly added dropwise to phosphorus trichloride (8.15 mL, 87.17 mmol) (8.15 mL, 87.17 mmol), and the dropwise addition time was controlled at 15 min. Subsequently, the reaction mixture was gradually warmed to room temperature and stirred continuously for 1 hour. Next, the reaction system was heated to 120 °C and stirring was continued for 4 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was carefully poured into pre-cooled ice water and extracted with dichloromethane (CH2Cl2, 3 x 100 mL). The organic phases were combined, washed sequentially with saturated sodium bicarbonate solution (100 mL) and water (100 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with 5% ethyl acetate/hexane as eluent, and the target compound 330 (1.4 g, 33% yield) was finally obtained as a brown oil.TLC conditions: 30% ethyl acetate/hexane (Rf=0.8).1H NMR (500 MHz, DMSO-d6): δ9.87 (s, 1H).
References
[1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992, # 8, p. 973 - 978
[2] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 1, p. 235 - 238
[3] Phosphorus, Sulfur and Silicon and the Related Elements, 2006, vol. 181, # 10, p. 2435 - 2444
[4] Patent: US2010/298334, 2010, A1. Location in patent: Page/Page column 78
[5] Chemistry of Heterocyclic Compounds, 2010, vol. 46, # 3, p. 334 - 341
2,4-Dichloro-5-thiazolecarboxaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Dichloro-5-thiazolecarboxaldehyde manufacturers
Career Henan Chemical Co
- Product
- 2,4-Dichloro-5-thiazolecarboxaldehyde 92972-48-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500KG
- Release date
- 2018-08-19
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