ChemicalBook > CAS DataBase List > 5-Chloro-2-methoxyphenylboronic acid

5-Chloro-2-methoxyphenylboronic acid

Product Name
5-Chloro-2-methoxyphenylboronic acid
CAS No.
89694-48-4
Chemical Name
5-Chloro-2-methoxyphenylboronic acid
Synonyms
AKOS BRN-0073;CHEMBRDG-BB 3200964;RARECHEM AH PB 0263;oro-2-methoxyphenyL;5-Chloro-2-methoxyph;5-Chloro-2-Methoxyphenylboroni;4-Chloroanisole-2-boronic acid;5-Chloro-2-methoxyphenylboronic;5-chloro-2-methoxyphenylboric acid;5-Chloro-2-methoxyphenyboronic acid
CBNumber
CB3344109
Molecular Formula
C7H8BClO3
Formula Weight
186.4
MOL File
89694-48-4.mol
More
Less

5-Chloro-2-methoxyphenylboronic acid Property

Melting point:
134-141 °C(lit.)
Boiling point:
360.2±52.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
7.58±0.58(Predicted)
form 
Crystalline Powder
color 
White
InChI
InChI=1S/C7H8BClO3/c1-12-7-3-2-5(9)4-6(7)8(10)11/h2-4,10-11H,1H3
InChIKey
FMBVAOHFMSQDGT-UHFFFAOYSA-N
SMILES
B(C1=CC(Cl)=CC=C1OC)(O)O
CAS DataBase Reference
89694-48-4(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29163990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
512249
Product name
5-Chloro-2-methoxyphenylboronic acid
Packaging
5g
Price
$50.9
Updated
2023/06/20
TCI Chemical
Product number
C2292
Product name
5-Chloro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging
5g
Price
$77
Updated
2025/07/31
TCI Chemical
Product number
C2292
Product name
5-Chloro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging
25g
Price
$229
Updated
2025/07/31
Matrix Scientific
Product number
002150
Product name
5-Chloro-2-methoxyphenylboronic acid
Purity
97%
Packaging
1g
Price
$10
Updated
2021/12/16
Synthonix
Product number
C2220
Product name
5-Chloro-2-methoxyphenylboronic acid
Purity
97%
Packaging
1g
Price
$15
Updated
2021/12/16
More
Less

5-Chloro-2-methoxyphenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

Reactant for:• ;Boron-Heck arylation1• ;Suzuki-Miyaura reaction2

Uses

suzuki reaction

Synthesis

121-43-7

60633-25-2

89694-48-4

The general procedure for the synthesis of 5-chloro-2-methoxyphenylboronic acid from trimethyl borate and 2-bromo-4-chloroanisole is as follows: 5-chloro-2-methoxyphenylboronic acid (Structure 37 of Scheme XI, wherein R1 = H, R2 = Cl) was prepared in a similar manner to 5-fluoro-2-methoxyphenylboronic acid (Example 107). This was done as follows: in a dry reaction flask, 2-bromo-4-chloroanisole (2.00 g, 9.0 mmol, 1.0 eq.) was added, cooled to -78°C under anhydrous and oxygen-free conditions, n-butyllithium (2.5 M hexane solution, 3.62 mL, 9.0 mmol, 1.0 eq.) was slowly added and the reaction was stirred for 30 minutes. Subsequently, trimethyl borate (3.0 mL, 26 mmol, 2.9 eq.) was added dropwise and the reaction was continued at -78°C for 2 hours. After completion of the reaction, it was slowly warmed to room temperature, the reaction was quenched with water, extracted with ethyl acetate, the organic phase was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to afford 1.30 g (77% yield) of crude 5-chloro-2-methoxyphenylboronic acid as a white semi-solid. The compound did not require further purification and could be used directly in the next step of the reaction. Next, the crude 5-chloro-2-methoxyphenylboronic acid was used for the synthesis of methyl (5'-chloro-2'-methoxy-4-nitro-2-biphenylyl) carboxylate (Structure 39 of Scheme XI, where R1 = H, R2 = Cl).

References

[1] Patent: US5688808, 1997, A
[2] Patent: US5688810, 1997, A
[3] Patent: US5693646, 1997, A
[4] Patent: US5693647, 1997, A
[5] Patent: US5696127, 1997, A

5-Chloro-2-methoxyphenylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5-Chloro-2-methoxyphenylboronic acid Suppliers

Americas 1 China 212 Europe 1 France 6 Germany 12 India 11 Italy 1 Japan 3 Russia 1 Switzerland 1 United Kingdom 13 United States 42 Global 304
Boron Technology (Beijing) Co., Ltd.
Tel
010-010-15313962280 15313962280
Fax
010-51669040
Email
3004509780@qq.com
Country
China
ProdList
824
Advantage
55
Hebei Maison Chemical Co.,Ltd.
Tel
155-11852758 15511852758
Fax
0311-83832777
Email
ruby@maisonchem.com.cn
Country
China
ProdList
550
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
2805
Advantage
65
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Puyang Huicheng Electronic Material Co. Ltd.
Tel
0393-0393-0393-8910800 15039333257
Fax
0393-8912775
Email
info@huichengchem.com
Country
China
ProdList
569
Advantage
64
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16077
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527621225
Email
1791901229@qq.com
Country
China
ProdList
6945
Advantage
52
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3295
Advantage
57
ChangZhou SIDU chemical Co., Ltd.
Tel
0519-81291281 18015082300
Fax
0519-81291281
Email
siduchem@hotmail.com
Country
China
ProdList
274
Advantage
62
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
7247
Advantage
62
Springchem New Material Technology Co.,Limited
Tel
+86-021-62885108 +8613917661608
Email
info@spring-chem.com
Country
China
ProdList
2068
Advantage
57
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9546
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Hebei Summedchem Co.,Ltd
Tel
0319-5801333-8008 15630992918
Email
sales@summedchem.com
Country
China
ProdList
965
Advantage
58
AllyChem Co., Ltd.
Tel
0411-62313318 13942603642
Fax
0411-87549748
Email
info@allychem.com
Country
China
ProdList
1028
Advantage
65
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9476
Advantage
58
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
NINGBO INNO PHARMCHEM CO.,LTD.
Tel
86-574-27787657
Fax
86-574-27912196
Email
info@dearchem.com
Country
China
ProdList
4613
Advantage
58
Credit-Chem Co., Ltd.
Tel
400-821-5857 021-64326257
Fax
021-64393586 QQ;2798200800
Email
credit-chem@foxmail.com
Country
China
ProdList
5219
Advantage
58
Shanghai Xingui Biotechnology Co., Ltd.
Tel
15121041756
Email
xingui2022@126.com
Country
China
ProdList
9986
Advantage
58
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14912
Advantage
59
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567 18521000990
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6479
Advantage
50
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66028182 18626450290
Email
yftan@aikonchem.com
Country
China
ProdList
16679
Advantage
50
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Giant chemicals
Tel
028-85434334 18108076537
Fax
QQ：245797092
Email
market@gianthx.com
Country
China
ProdList
4505
Advantage
56
Shanghai Uchem Inc.
Tel
15618758386; 15618758386
Fax
QQ:3004479444
Email
sales3@myuchem.com
Country
China
ProdList
1999
Advantage
55
CHMA Chemical Technology (Shanghai) Co., Ltd
Tel
021-61556450 15800904410
Fax
021-61556450
Country
China
ProdList
2832
Advantage
58
More
Less

View Lastest Price from 5-Chloro-2-methoxyphenylboronic acid manufacturers

Henan Fengda Chemical Co., Ltd
Product
5-Chloro-2-methoxyphenylboronic acid 89694-48-4
Price
US $34.00-1.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08
Guangzhou Sunton Biotechnology Co., Ltd.
Product
5-Chloro-2-methoxyphenylboronic acid 89694-48-4
Price
US $48.00-40.00/Kg
Min. Order
1KG
Purity
99%
Supply Ability
200tons
Release date
2021-04-18
LY Global chemicals co.,ltd .
Product
5-Chloro-2-methoxyphenylboronic acid 89694-48-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%Min
Supply Ability
1000kg
Release date
2023-03-12

89694-48-4, 5-Chloro-2-methoxyphenylboronic acidRelated Search:

(Trifluoromethoxy)benzene Phenylboronic acid 4-Methoxybenzoic acid Epichlorohydrin 4-Methoxyphenylboronic acid p-Anisaldehyde Anisole 3-(METHOXYMETHOXY)BENZALDEHYDE 3-Methoxyacetophenone 4'-Methoxyacetophenone (4-METHOXYPHENYL)-BORANE 4-Methoxybenzylchloride Ethyl 2-(Chlorosulfonyl)acetate 5-CHLORO-2-ETHOXYPHENYLBORONIC ACID 2-BENZYLOXY-5-CHLOROPHENYLBORONIC ACID Chloroacetic acid Difluorochloromethane 4-CHLORO-2-METHOXYPHENYLBORONIC ACID

  • RARECHEM AH PB 0263
  • CHEMBRDG-BB 3200964
  • AKOS BRN-0073
  • 5-CHLORO-2-METHOXY-BENZENEBORONIC ACID
  • 5-CHLORO-2-METHOXYPHENYLBORONIC ACID
  • 5-Chloro-2-Methoxyphenylboroni
  • 5-CHLORO-2-METHOXPHENYL BORONIC ACID
  • 4-Chloroanisole-2-boronic acid
  • 5-Chloro-2-methoxyphenylboronic acid 89694-48-4
  • 89694-48-4 5-Chloro-2-methoxyphenylboronic acid
  • 5-Chloro-2-methoxyphenylboronic
  • 5-Chloro-2-methoxyphenylboronic acid ,98%
  • 5-Chloro-2-methoxyph
  • (5-chloro-2-methoxyphenyl)boronic acid(SALTDATA: FREE)
  • 2-Borono-4-chloroanisole, 2-Borono-4-chlorophenyl methyl ether
  • 5-Chloro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
  • 2-Methoxy-5-chlorophenylboronic acid
  • 3-Chloro-6-methoxyphenylboronic acid
  • 5-Chloro-2-methoxyphenyboronic acid
  • oro-2-methoxyphenyL
  • Boronic acid, B-(5-chloro-2-methoxyphenyl)-
  • 5-chloro-2-methoxyphenylboric acid
  • (5-Chloro-2-methoxyphenyl)boronic acid - [C2220]
  • 89694-48-4
  • C7H8BCIO3
  • ClC6H3OCH3BOH2
  • BORONIC ACID
  • Aryl
  • Boronic Acids
  • Boronic Acids and Derivatives
  • Organometallic Reagents
  • Boronate Ester
  • Potassium Trifluoroborate
  • Aryl Boronic Acids
  • Boronic Acids and Derivatives
  • Chemical Synthesis
  • Disubstituted Aryl Boronic Acids
  • Organometallic Reagents
  • Boronic Acids & Esters
  • Phenyls & Phenyl-Het
  • Benzene derivatives
  • Boronic Acids
  • Boronic Acids and Derivatives
  • B (Classes of Boron Compounds)
  • Boronic Acids
  • Alkoxy
  • Aryl
  • Organoborons
  • Boronic Acids & Esters
  • Phenyls & Phenyl-Het
  • Boronic Acid
  • blocks
  • BoronicAcids