5-Chloro-2-methoxyphenylboronic acid
- Product Name
- 5-Chloro-2-methoxyphenylboronic acid
- CAS No.
- 89694-48-4
- Chemical Name
- 5-Chloro-2-methoxyphenylboronic acid
- Synonyms
- AKOS BRN-0073;CHEMBRDG-BB 3200964;RARECHEM AH PB 0263;oro-2-methoxyphenyL;5-Chloro-2-methoxyph;5-Chloro-2-Methoxyphenylboroni;4-Chloroanisole-2-boronic acid;5-Chloro-2-methoxyphenylboronic;5-chloro-2-methoxyphenylboric acid;5-Chloro-2-methoxyphenyboronic acid
- CBNumber
- CB3344109
- Molecular Formula
- C7H8BClO3
- Formula Weight
- 186.4
- MOL File
- 89694-48-4.mol
5-Chloro-2-methoxyphenylboronic acid Property
- Melting point:
- 134-141 °C(lit.)
- Boiling point:
- 360.2±52.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 7.58±0.58(Predicted)
- form
- Crystalline Powder
- color
- White
- InChI
- InChI=1S/C7H8BClO3/c1-12-7-3-2-5(9)4-6(7)8(10)11/h2-4,10-11H,1H3
- InChIKey
- FMBVAOHFMSQDGT-UHFFFAOYSA-N
- SMILES
- B(C1=CC(Cl)=CC=C1OC)(O)O
- CAS DataBase Reference
- 89694-48-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 512249
- Product name
- 5-Chloro-2-methoxyphenylboronic acid
- Packaging
- 5g
- Price
- $50.9
- Updated
- 2023/06/20
- Product number
- C2292
- Product name
- 5-Chloro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $77
- Updated
- 2025/07/31
- Product number
- C2292
- Product name
- 5-Chloro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 25g
- Price
- $229
- Updated
- 2025/07/31
- Product number
- 002150
- Product name
- 5-Chloro-2-methoxyphenylboronic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- C2220
- Product name
- 5-Chloro-2-methoxyphenylboronic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
5-Chloro-2-methoxyphenylboronic acid Chemical Properties,Usage,Production
Chemical Properties
White to off-white powder
Uses
Reactant for:• ;Boron-Heck arylation1• ;Suzuki-Miyaura reaction2
Uses
suzuki reaction
Synthesis
121-43-7
60633-25-2
89694-48-4
The general procedure for the synthesis of 5-chloro-2-methoxyphenylboronic acid from trimethyl borate and 2-bromo-4-chloroanisole is as follows: 5-chloro-2-methoxyphenylboronic acid (Structure 37 of Scheme XI, wherein R1 = H, R2 = Cl) was prepared in a similar manner to 5-fluoro-2-methoxyphenylboronic acid (Example 107). This was done as follows: in a dry reaction flask, 2-bromo-4-chloroanisole (2.00 g, 9.0 mmol, 1.0 eq.) was added, cooled to -78°C under anhydrous and oxygen-free conditions, n-butyllithium (2.5 M hexane solution, 3.62 mL, 9.0 mmol, 1.0 eq.) was slowly added and the reaction was stirred for 30 minutes. Subsequently, trimethyl borate (3.0 mL, 26 mmol, 2.9 eq.) was added dropwise and the reaction was continued at -78°C for 2 hours. After completion of the reaction, it was slowly warmed to room temperature, the reaction was quenched with water, extracted with ethyl acetate, the organic phase was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to afford 1.30 g (77% yield) of crude 5-chloro-2-methoxyphenylboronic acid as a white semi-solid. The compound did not require further purification and could be used directly in the next step of the reaction. Next, the crude 5-chloro-2-methoxyphenylboronic acid was used for the synthesis of methyl (5'-chloro-2'-methoxy-4-nitro-2-biphenylyl) carboxylate (Structure 39 of Scheme XI, where R1 = H, R2 = Cl).
References
[1] Patent: US5688808, 1997, A
[2] Patent: US5688810, 1997, A
[3] Patent: US5693646, 1997, A
[4] Patent: US5693647, 1997, A
[5] Patent: US5696127, 1997, A
5-Chloro-2-methoxyphenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Chloro-2-methoxyphenylboronic acid manufacturers
- Product
- 5-Chloro-2-methoxyphenylboronic acid 89694-48-4
- Price
- US $34.00-1.20/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 5-Chloro-2-methoxyphenylboronic acid 89694-48-4
- Price
- US $48.00-40.00/Kg
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200tons
- Release date
- 2021-04-18
- Product
- 5-Chloro-2-methoxyphenylboronic acid 89694-48-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%Min
- Supply Ability
- 1000kg
- Release date
- 2023-03-12