ChemicalBook > CAS DataBase List > Fmoc-Trp(Boc)-OH

Fmoc-Trp(Boc)-OH

Product Name: Fmoc-Trp(Boc)-OH
CAS No.: 143824-78-6
Chemical Name: Fmoc-Trp(Boc)-OH
Synonyms: FMOC-L-TRP(BOC)-OH;FMOC-TRP(BOC);FMOC-L-TRP(BOC);N1-Boc-NaL;pha-Fmoc-L;FMOC-TRP(BOC)-OH;Fomc-Trp(Boc)-OH;Fmoc-Trp(Boc)-0H;FMOC-L-TRYPTOPHANE;FMOC-L-TRP(TBOC)-OH
CBNumber: CB3360314
Molecular Formula: C31H30N2O6
Formula Weight: 526.58
MOL File: 143824-78-6.mol

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Fmoc-Trp(Boc)-OH Property

Melting point:: ca 97℃
alpha: -21 º (c=1%, DMF)
Density: 1.28±0.1 g/cm3(Predicted)
refractive index: -20 ° (C=1, DMF)
storage temp.: 2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka: 3.71±0.10(Predicted)
form: Solid
color: White to Orange to Green
optical activity: [α]20/D 21±2°, c = 1% in DMF
Sensitive: Moisture Sensitive
BRN: 7698009
InChIKey: ADOHASQZJSJZBT-SANMLTNESA-N
SMILES: C(O)(=O)[C@H](CC1C2=C(C=CC=C2)N(C(OC(C)(C)C)=O)C=1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference: 143824-78-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,N
Risk Statements: 36/37/38-51/53-43
Safety Statements: 22-24/25-36/37/39-27-26-61-37-24
RIDADR: 3077
WGK Germany: 3
F: 10-21
HazardClass: 9
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H401Toxic to aquatic life

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52050
Product name: Fmoc-Trp(Boc)-OH
Purity: Novabiochem?
Packaging: 25g
Price: $201
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52050
Product name: Fmoc-Trp(Boc)-OH
Purity: Novabiochem?
Packaging: 100g
Price: $525
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52050
Product name: Fmoc-Trp(Boc)-OH
Purity: Novabiochem?
Packaging: 250g
Price: $1120
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52050
Product name: Fmoc-Trp(Boc)-OH
Purity: Novabiochem®
Packaging: 500 g
Price: $2220
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52050
Product name: Fmoc-Trp(Boc)-OH
Purity: Novabiochem®
Packaging: 500 g
Price: $2220
Updated: 2025/07/31

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Fmoc-Trp(Boc)-OH Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Fmoc-Trp(Boc)-OH is a very useful synthetic intermediate. It is used to prepare Trp containing-peptides.

Uses

Fmoc-Trp(Boc)-OH can be used for the synthesis of analogs of glucagon-like peptide-1 (GLP-1) for the treatment of type 2 diabetes and various peptides by Fmoc solid phase peptide synthesis (SPPS).

General Description

The use of Fmoc-Trp(Boc)-OH overcomes most of the problems associated with the preparation of Trp containing-peptides by Fmoc SPPS [1]. Cleavage with TFA generates an N-in-carboxy indole which protects the Trp from alkylation [1, 2, 3] and sulfonation [1, 4, 5, 6, 7]. The N-in-carboxy group is removed under aqueous conditions during normal work-up of the peptide.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

The synthesis of Fmoc-Trp(Boc)-OH typically begins with tryptophan, which is then selectively protected using the Boc group. The Fmoc group is introduced through a reaction with 9-fluorenylmethoxycarbonyl chloride.

Fmoc-Trp(Boc)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Fmoc-Trp(Boc)-OH manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: Fmoc-Trp(Boc)-OH 143824-78-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2025-09-22

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Fmoc-Trp(Boc)-OH 143824-78-6
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kg
Release date: 2021-08-28

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-Trp(Boc)-OH 143824-78-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-12-06

143824-78-6, Fmoc-Trp(Boc)-OHRelated Search:

Fmoc-Lys(Boc)-OH L-Tryptophan BUTYL OLEATE 9-Fluorenylmethyl chloroformate tert-Butyl acetate N-(tert-Butoxycarbonyl)-L-alanine L-5-Hydroxytryptophan Fmoc-Phe-OH Nalpha-Fmoc-Ndelta-trityl-L-glutamine L-Fmoc-Aspartic acid alpha-tert-butyl ester METHOXYCARBONYLSULFENYL CHLORIDE Cyhalofop-butyl Butyl acetate Boc-Aib-OH 2-Butoxyethanol Buprofezin Fmoc-OSu tert-Butanol

FMOC-TRP(BOC)-OH

FMOC-TRP(BOC)

FMOC-TRYPTOPHAN(BOC)-OH

FMOC-NIN-T-BUTYLOXYCARBONYL-L-TRYPTOPHAN

FMOC-N-IN-BOC-L-TRYPTOPHAN

FMOC-N-BOC-L-TRYPTOPHAN

FMOC-L-TRP(BOC)

FMOC-L-TRP(BOC)-OH

FMOC-L-TRYPTOPHAN(BOC)

FMOC-L-TRYPTOPHAN (TBOC)

FMOC-L-TRP(TBOC)-OH

N-ALPHA-FMOC-N-IN-T-BOC-L-TRYPTOPHAN

N-ALPHA-FMOC-N(IN)-BOC-L-TRYPTOPHAN

N-ALPHA-FMOC-N-IN-TERT-BOC-L-TRYPTOPHAN

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-IN-T-BUTOXYCARBONYL-L-TRYPTOPHAN

N-ALPHA-9-FLUORENYLMETHOXYCARBONYL-NIN-T-BUTYLOXYCARBONYL-L-TRYPTOPHAN

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-IN-T-BUTYL-OXYCARBONYL-L-TRYPTOPHAN

NALPHA-9-FLUORENYLMETHYLOXYCARBONYL-N(IN)-TERT-BUTOXYCARBONYL-L-TRYPTOPHAN

N ALPHA-9-FLUORENYLMETHYLOXYCARBONYL-N(IN)-T-BUTOXYCARBONYL-L-TRYPTOPHAN

Fmoc-Trp(Boc)-OH ,98%

FMoc-Trp(Boc)-OH N-α-FMoc-N-in-Boc-L-tryptophan

1-Boc-N^a-FMoc-L-tryptophan, 97%

1-Boc-N-FMoc-L-tryptophan, 97%

N1-Boc-Nalpha-Fmoc-L-tryptophan Fmoc-Trp(Boc)-OH

Fmoc-Trp(Boc)-OH >=97.0% (HPLC)

(2S)-3-{1-[(tert-Butoxy)carbonyl]-1H-indol-3-yl}-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid

Nα-Fmoc-Nin-Boc-L-tryptophan≥ 98% (HPLC)

(9H-Fluoren-9-yl)MethOxy]Carbonyl Trp(Boc)-OH

N-Fmoc-NIn-Boc-L-trp

Fmoc-Trp(Boc)-OH (contains 8% solvents)

(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[1-[(2-methylpropan-2-yl)oxycarbonyl]indol-3-yl]propanoic acid

(2R)-3-{1-[(tert-butoxy)carbonyl]-1H-indol-3-yl}-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid

Fmoc-Trp(Boc)-OH, 97.0%

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)propanoicacid

N(in)-Boc-Nα-Fmoc-L-tryptophan

Nα-Fmoc-N(in)-Boc-L-tryptophan

N-tert-Butoxycarbonyl-N-9-fluorenylmethoxycarbonyl-L-tryptophan

N-α-Fmoc-N-in-Boc-L-tryptophan

FMOC-TRP(BOC)-OH 99+%

N-ALPHA-(9-FLUOROENYLMETHYLOXYCARBONYL)-N-IN-T-BUTYLOXYCARBONYL-L-TRYPTOPHAN

FMOC-L-TRYPTOPHANE

N (in) -Boc- N α -Fmoc- L -tryptophan

Nin-tert-Butoxycarbonyl-NALPHA-9-fluorenylmethoxycarbonyl-L-tryptophan

FMOC-N-BOC-L-TRYPTOPHAN (FMOC-L-TRP(BOC)-OH)

1-[(TERT-BUTYL)CARBONYL]-N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-TRYPTOPHAN

Nα-Fmoc-N(in)-Boc-L-tryptophan, N(in)-Boc-Nα-Fmoc-L-tryptophan

N1-Boc-Nalpha-Fmoc-L-tryptophan

Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N1-tert-butoxycarbonyl-L-tryptophan

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-IN-TERT-BUTYLOXYCARBONYL-L-TRYPTOPHAN

N(IN)-BOC-N-ALPHA-FMOC-L-TRYPTOPHAN

Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N1-tert-butoxycarbonyl-L-tryptophan&gt

FMOC-TRP(BOC)-OH 25 G

FMOC-TRP(BOC)-OH 100 G

N1-Boc-NaL

pha-Fmoc-L

L-Tryptophan, 1-[(1,1-dimethylethoxy)carbonyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-

N(α)-fmoc-N(in)-boc-L-tryptophan

(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[1-[(2-methylpropan-2-yl)oxycarbonyl]indol-3-yl]propanoicaci