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Fmoc-Trp(Boc)-OH

Product Name
Fmoc-Trp(Boc)-OH
CAS No.
143824-78-6
Chemical Name
Fmoc-Trp(Boc)-OH
Synonyms
FMOC-L-TRP(BOC)-OH;FMOC-TRP(BOC);FMOC-L-TRP(BOC);N1-Boc-NaL;pha-Fmoc-L;FMOC-TRP(BOC)-OH;Fomc-Trp(Boc)-OH;Fmoc-Trp(Boc)-0H;FMOC-L-TRYPTOPHANE;FMOC-L-TRP(TBOC)-OH
CBNumber
CB3360314
Molecular Formula
C31H30N2O6
Formula Weight
526.58
MOL File
143824-78-6.mol
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Fmoc-Trp(Boc)-OH Property

Melting point:
ca 97℃
alpha 
-21 º (c=1%, DMF)
Density 
1.28±0.1 g/cm3(Predicted)
refractive index 
-20 ° (C=1, DMF)
storage temp. 
2-8°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka
3.71±0.10(Predicted)
form 
Solid
color 
White to Orange to Green
optical activity
[α]20/D 21±2°, c = 1% in DMF
Sensitive 
Moisture Sensitive
BRN 
7698009
InChIKey
ADOHASQZJSJZBT-SANMLTNESA-N
SMILES
C(O)(=O)[C@H](CC1C2=C(C=CC=C2)N(C(OC(C)(C)C)=O)C=1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference
143824-78-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,N
Risk Statements 
36/37/38-51/53-43
Safety Statements 
22-24/25-36/37/39-27-26-61-37-24
RIDADR 
3077
WGK Germany 
3
F 
10-21
HazardClass 
9
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H401Toxic to aquatic life

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.52050
Product name
Fmoc-Trp(Boc)-OH
Purity
Novabiochem?
Packaging
25g
Price
$201
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52050
Product name
Fmoc-Trp(Boc)-OH
Purity
Novabiochem?
Packaging
100g
Price
$525
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52050
Product name
Fmoc-Trp(Boc)-OH
Purity
Novabiochem?
Packaging
250g
Price
$1120
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52050
Product name
Fmoc-Trp(Boc)-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
500 g
Price
$2220
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52050
Product name
Fmoc-Trp(Boc)-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
500 g
Price
$2220
Updated
2025/07/31
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Fmoc-Trp(Boc)-OH Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Fmoc-Trp(Boc)-OH is a very useful synthetic intermediate. It is used to prepare Trp containing-peptides.

Uses

Fmoc-Trp(Boc)-OH can be used for the synthesis of analogs of glucagon-like peptide-1 (GLP-1) for the treatment of type 2 diabetes and various peptides by Fmoc solid phase peptide synthesis (SPPS).

General Description

The use of Fmoc-Trp(Boc)-OH overcomes most of the problems associated with the preparation of Trp containing-peptides by Fmoc SPPS [1]. Cleavage with TFA generates an N-in-carboxy indole which protects the Trp from alkylation [1, 2, 3] and sulfonation [1, 4, 5, 6, 7]. The N-in-carboxy group is removed under aqueous conditions during normal work-up of the peptide.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

The synthesis of Fmoc-Trp(Boc)-OH typically begins with tryptophan, which is then selectively protected using the Boc group. The Fmoc group is introduced through a reaction with 9-fluorenylmethoxycarbonyl chloride.

Fmoc-Trp(Boc)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-Trp(Boc)-OH Suppliers

Americas 1 Canada 2 China 399 Europe 5 France 2 Germany 7 India 12 Japan 4 Poland 1 South Korea 1 Switzerland 7 United Kingdom 15 United States 52 Global 508
Christof Senn Laboratories AG
Tel
--
Fax
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Email
christof.senn@cslabs.ch
Country
Switzerland
ProdList
502
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58
Bachem AG
Tel
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Fax
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Email
sales.ch@bachem.com
Country
Switzerland
ProdList
438
Advantage
58
Bachem AG
Tel
--
Fax
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Email
bachem.sale@yahoo.com
Country
Switzerland
ProdList
291
Advantage
81
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
AXXORA, LLC
Tel
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Fax
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Email
alexis-ch@alexis-corp.com
Country
Switzerland
ProdList
1104
Advantage
80
Alexis Corporation
Tel
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Fax
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Email
alexis-ch@alexis-corp.ch
Country
Switzerland
ProdList
3599
Advantage
74
Senn Chemicals AG
Tel
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Fax
--
Email
swiss@sennchem.com
Country
Switzerland
ProdList
3143
Advantage
71
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View Lastest Price from Fmoc-Trp(Boc)-OH manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
Product
Fmoc-Trp(Boc)-OH 143824-78-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2025-09-22
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Fmoc-Trp(Boc)-OH 143824-78-6
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kg
Release date
2021-08-28
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Fmoc-Trp(Boc)-OH 143824-78-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T
Release date
2023-12-06

143824-78-6, Fmoc-Trp(Boc)-OHRelated Search:

Fmoc-Lys(Boc)-OH L-Tryptophan BUTYL OLEATE 9-Fluorenylmethyl chloroformate tert-Butyl acetate N-(tert-Butoxycarbonyl)-L-alanine L-5-Hydroxytryptophan Fmoc-Phe-OH Nalpha-Fmoc-Ndelta-trityl-L-glutamine L-Fmoc-Aspartic acid alpha-tert-butyl ester METHOXYCARBONYLSULFENYL CHLORIDE Cyhalofop-butyl Butyl acetate Boc-Aib-OH 2-Butoxyethanol Buprofezin Fmoc-OSu tert-Butanol

  • FMOC-TRP(BOC)-OH
  • FMOC-TRP(BOC)
  • FMOC-TRYPTOPHAN(BOC)-OH
  • FMOC-NIN-T-BUTYLOXYCARBONYL-L-TRYPTOPHAN
  • FMOC-N-IN-BOC-L-TRYPTOPHAN
  • FMOC-N-BOC-L-TRYPTOPHAN
  • FMOC-L-TRP(BOC)
  • FMOC-L-TRP(BOC)-OH
  • FMOC-L-TRYPTOPHAN(BOC)
  • FMOC-L-TRYPTOPHAN (TBOC)
  • FMOC-L-TRP(TBOC)-OH
  • N-ALPHA-FMOC-N-IN-T-BOC-L-TRYPTOPHAN
  • N-ALPHA-FMOC-N(IN)-BOC-L-TRYPTOPHAN
  • N-ALPHA-FMOC-N-IN-TERT-BOC-L-TRYPTOPHAN
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-IN-T-BUTOXYCARBONYL-L-TRYPTOPHAN
  • N-ALPHA-9-FLUORENYLMETHOXYCARBONYL-NIN-T-BUTYLOXYCARBONYL-L-TRYPTOPHAN
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-IN-T-BUTYL-OXYCARBONYL-L-TRYPTOPHAN
  • NALPHA-9-FLUORENYLMETHYLOXYCARBONYL-N(IN)-TERT-BUTOXYCARBONYL-L-TRYPTOPHAN
  • N ALPHA-9-FLUORENYLMETHYLOXYCARBONYL-N(IN)-T-BUTOXYCARBONYL-L-TRYPTOPHAN
  • Fmoc-Trp(Boc)-OH ,98%
  • FMoc-Trp(Boc)-OH N-α-FMoc-N-in-Boc-L-tryptophan
  • 1-Boc-N^a-FMoc-L-tryptophan, 97%
  • 1-Boc-N-FMoc-L-tryptophan, 97%
  • N1-Boc-Nalpha-Fmoc-L-tryptophan Fmoc-Trp(Boc)-OH
  • Fmoc-Trp(Boc)-OH >=97.0% (HPLC)
  • (2S)-3-{1-[(tert-Butoxy)carbonyl]-1H-indol-3-yl}-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
  • Nα-Fmoc-Nin-Boc-L-tryptophan≥ 98% (HPLC)
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl Trp(Boc)-OH
  • N-Fmoc-NIn-Boc-L-trp
  • Fmoc-Trp(Boc)-OH (contains 8% solvents)
  • (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[1-[(2-methylpropan-2-yl)oxycarbonyl]indol-3-yl]propanoic acid
  • (2R)-3-{1-[(tert-butoxy)carbonyl]-1H-indol-3-yl}-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
  • Fmoc-Trp(Boc)-OH, 97.0%
  • (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)propanoicacid
  • N<SUB>(in)</SUB>-Boc-N<SUB>α</SUB>-Fmoc-L-tryptophan
  • N<SUB>α</SUB>-Fmoc-N<SUB>(in)</SUB>-Boc-L-tryptophan
  • N-tert-Butoxycarbonyl-N-9-fluorenylmethoxycarbonyl-L-tryptophan
  • N-α-Fmoc-N-in-Boc-L-tryptophan
  • FMOC-TRP(BOC)-OH 99+%
  • N-ALPHA-(9-FLUOROENYLMETHYLOXYCARBONYL)-N-IN-T-BUTYLOXYCARBONYL-L-TRYPTOPHAN
  • FMOC-L-TRYPTOPHANE
  • N (in) -Boc- N α -Fmoc- L -tryptophan
  • Nin-tert-Butoxycarbonyl-NALPHA-9-fluorenylmethoxycarbonyl-L-tryptophan
  • FMOC-N-BOC-L-TRYPTOPHAN (FMOC-L-TRP(BOC)-OH)
  • 1-[(TERT-BUTYL)CARBONYL]-N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-TRYPTOPHAN
  • Nα-Fmoc-N(in)-Boc-L-tryptophan, N(in)-Boc-Nα-Fmoc-L-tryptophan
  • N1-Boc-Nalpha-Fmoc-L-tryptophan
  • Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N1-tert-butoxycarbonyl-L-tryptophan
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-IN-TERT-BUTYLOXYCARBONYL-L-TRYPTOPHAN
  • N(IN)-BOC-N-ALPHA-FMOC-L-TRYPTOPHAN
  • Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N1-tert-butoxycarbonyl-L-tryptophan&gt
  • FMOC-TRP(BOC)-OH 25 G
  • FMOC-TRP(BOC)-OH 100 G
  • N1-Boc-NaL
  • pha-Fmoc-L
  • L-Tryptophan, 1-[(1,1-dimethylethoxy)carbonyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
  • N(α)-fmoc-N(in)-boc-L-tryptophan
  • (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[1-[(2-methylpropan-2-yl)oxycarbonyl]indol-3-yl]propanoicaci