Fluocortolone
- Product Name
- Fluocortolone
- CAS No.
- 152-97-6
- Chemical Name
- Fluocortolone
- Synonyms
- flucortolone;FLUORCORTOLONE;SH-742;SH 742;Fluocortolon;FLUOCORTOLONE;Fluorocortolone;Fluocortolone USP/EP/BP;Fluocortolone Impurity 13;methylfluorodehydrocorticosterone
- CBNumber
- CB3378252
- Molecular Formula
- C22H29FO4
- Formula Weight
- 376.46
- MOL File
- 152-97-6.mol
Fluocortolone Property
- Melting point:
- 113-116°C
- alpha
- D20 +100° (dioxane)
- Boiling point:
- 537.4±50.0 °C(Predicted)
- Density
- 1.1001 (estimate)
- vapor pressure
- 0.001Pa at 25℃
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Dioxane (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 12.98±0.10(Predicted)
- color
- Pale Yellow to Yellow
- Water Solubility
- 204mg/L at 20℃
- LogP
- 2.3 at 25℃
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H360May damage fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P314Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F500500
- Product name
- Fluocortolone
- Packaging
- 1mg
- Price
- $205
- Updated
- 2021/12/16
- Product number
- F500500
- Product name
- Fluocortolone
- Packaging
- 5mg
- Price
- $925
- Updated
- 2021/12/16
- Product number
- SHG0007194
- Product name
- FLUOCORTOLONE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $2887.5
- Updated
- 2021/12/16
- Product number
- 70263
- Product name
- Fluocortolone
- Packaging
- 1mg
- Price
- $675
- Updated
- 2021/12/16
- Product number
- SHG0007194
- Product name
- FLUOCORTOLONE
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $866.25
- Updated
- 2021/12/16
Fluocortolone Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Solid
Originator
Ultralan,Schering,W. Germany,1965
Uses
Fluocortolone is a glucocorticoid used in the treatment of several conditions, including hemorrhoids. Fluocortolone is similar to Fluocortin, but with one less keto group.
Definition
ChEBI: Fluocortolone is a 21-hydroxy steroid.
Manufacturing Process
(a) 16α-Methyl-6α-Fluoro-δ4-11β,21-Diol-3,20-Dione:16α-methyl-6α-fluoro-δ4-
pregnene-21-ol-3,20-dione-21-acetate (MP 132°/134° to 138°C, UVε238=
15,000) is hydroxylated with Curvularia lunata in 11β-position using the
fermentation method whereby the 21-acetate group is simultaneously
saponified. The hitherto unknown starting material 16α-methyl-6α-fluoro-δ4-
pregnene-21-ol-3,20-dione-21-acetate is obtained from 16α-methyl-δ5-
pregnene-3β,21-diol-20-one-21-acetate, MP 152° to 154°C, by the addition of
bromofluorine (from N-bromoacetamide and hydrogen fluoride) onto the 5-6
double bond, oxidation of the 3β-hydroxyl group with chromic acid,
introduction of the δ4-double bond by splitting of the hydrogen bromide and
acid isomerization of the 6β-fluoro substituent to the 16α-methyl-6α-fluoro-δ4-
pregnene-21-ol-3,20-dione-21-acetate. By chromatographic purification on
silica gel the 16α-methyl-6α-fluoro-δ4-pregnene-11β,21-diol-3,20-dione is: MP
166°/167° to 171°C.
(b) 16α-Methyl-6α-Fluoro-δ4-Pregnene-11β,21-Diol-3,20-Dione-21-Acetate:By
reaction of the compound of (a) with acetic anhydride in pyridine at room
temperature, the acetate is obtained and recrystallized from ethyl acetate, MP
248°/249° to 251°C.
(c) 16α-Methyl-6α-Fluoro-δ1,4-Pregnadiene-11β,21-Diol-3,20-Dione:16α-
methyl-6α-fluoro-δ4-pregnene-11β,21-diol-3,20-dione is dehydrogenated with
Corynebacterium simplex. The extraction residue is subjected to
chromatography on silica gel and after recrystallization there is obtained from
methylene chloride-isopropyl ether 16α-methyl-6α-fluoro-δ1,4-pregnadiene-
11β,21-diol-3,20-dione, MP 180°/181° to 182°C.
Therapeutic Function
Glucocorticoid
Flammability and Explosibility
Not classified
Fluocortolone Preparation Products And Raw materials
Raw materials
Preparation Products
Fluocortolone Suppliers
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View Lastest Price from Fluocortolone manufacturers
- Product
- Fluocortolone 152-97-6
- Price
- US $550.00/KG
- Min. Order
- 1KG
- Purity
- 99
- Supply Ability
- 1000KG
- Release date
- 2020-11-12
- Product
- Fluocortolone 152-97-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%-99.9%
- Supply Ability
- 200kg
- Release date
- 2020-01-12