Fluocortolone

Product Name: Fluocortolone
CAS No.: 152-97-6
Chemical Name: Fluocortolone
Synonyms: flucortolone;FLUORCORTOLONE;SH-742;SH 742;Fluocortolon;FLUOCORTOLONE;Fluorocortolone;Fluocortolone USP/EP/BP;Fluocortolone Impurity 13;methylfluorodehydrocorticosterone
CBNumber: CB3378252
Molecular Formula: C22H29FO4
Formula Weight: 376.46
MOL File: 152-97-6.mol

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Fluocortolone Property

Melting point:: 113-116°C
alpha: D20 +100° (dioxane)
Boiling point:: 537.4±50.0 °C(Predicted)
Density: 1.1001 (estimate)
vapor pressure: 0.001Pa at 25℃
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Dioxane (Slightly), Methanol (Slightly)
form: Solid
pka: 12.98±0.10(Predicted)
color: Pale Yellow to Yellow
Water Solubility: 204mg/L at 20℃
LogP: 2.3 at 25℃

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H360May damage fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: F500500
Product name: Fluocortolone
Packaging: 1mg
Price: $205
Updated: 2021/12/16

TRC

Product number: F500500
Product name: Fluocortolone
Packaging: 5mg
Price: $925
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: SHG0007194
Product name: FLUOCORTOLONE
Purity: 95.00%
Packaging: 10MG
Price: $2887.5
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 70263
Product name: Fluocortolone
Packaging: 1mg
Price: $675
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: SHG0007194
Product name: FLUOCORTOLONE
Purity: 95.00%
Packaging: 1MG
Price: $866.25
Updated: 2021/12/16

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Fluocortolone Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Originator

Ultralan,Schering,W. Germany,1965

Uses

Fluocortolone is a glucocorticoid used in the treatment of several conditions, including hemorrhoids. Fluocortolone is similar to Fluocortin, but with one less keto group.

Definition

ChEBI: Fluocortolone is a 21-hydroxy steroid.

Manufacturing Process

(a) 16α-Methyl-6α-Fluoro-δ4-11β,21-Diol-3,20-Dione:16α-methyl-6α-fluoro-δ4- pregnene-21-ol-3,20-dione-21-acetate (MP 132°/134° to 138°C, UVε238= 15,000) is hydroxylated with Curvularia lunata in 11β-position using the fermentation method whereby the 21-acetate group is simultaneously saponified. The hitherto unknown starting material 16α-methyl-6α-fluoro-δ4- pregnene-21-ol-3,20-dione-21-acetate is obtained from 16α-methyl-δ5- pregnene-3β,21-diol-20-one-21-acetate, MP 152° to 154°C, by the addition of bromofluorine (from N-bromoacetamide and hydrogen fluoride) onto the 5-6 double bond, oxidation of the 3β-hydroxyl group with chromic acid, introduction of the δ4-double bond by splitting of the hydrogen bromide and acid isomerization of the 6β-fluoro substituent to the 16α-methyl-6α-fluoro-δ4- pregnene-21-ol-3,20-dione-21-acetate. By chromatographic purification on silica gel the 16α-methyl-6α-fluoro-δ4-pregnene-11β,21-diol-3,20-dione is: MP 166°/167° to 171°C.
(b) 16α-Methyl-6α-Fluoro-δ4-Pregnene-11β,21-Diol-3,20-Dione-21-Acetate:By reaction of the compound of (a) with acetic anhydride in pyridine at room temperature, the acetate is obtained and recrystallized from ethyl acetate, MP 248°/249° to 251°C.
(c) 16α-Methyl-6α-Fluoro-δ1,4-Pregnadiene-11β,21-Diol-3,20-Dione:16α- methyl-6α-fluoro-δ4-pregnene-11β,21-diol-3,20-dione is dehydrogenated with Corynebacterium simplex. The extraction residue is subjected to chromatography on silica gel and after recrystallization there is obtained from methylene chloride-isopropyl ether 16α-methyl-6α-fluoro-δ1,4-pregnadiene- 11β,21-diol-3,20-dione, MP 180°/181° to 182°C.

Therapeutic Function

Glucocorticoid

Flammability and Explosibility

Not classified

Fluocortolone Preparation Products And Raw materials

Raw materials

Preparation Products

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Fluocortolone Suppliers

Canada 1 China 35 France 1 India 4 United Kingdom 2 United States 11 Global 54

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View Lastest Price from Fluocortolone manufacturers

Longyan Tianhua Biological Technology Co., Ltd

Product: Fluocortolone 152-97-6
Price: US $550.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 1000KG
Release date: 2020-11-12

Career Henan Chemical Co

Product: Fluocortolone 152-97-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%-99.9%
Supply Ability: 200kg
Release date: 2020-01-12

152-97-6, FluocortoloneRelated Search:

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6-fluoro-11-hydroxy-17-(2-hydroxy-1-oxoethyl)-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one

(6s,8s,9r,10s,11s,13s,14s,16r,17s)-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one

6-alpha-fluoro-11-beta,21-dihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione

methylfluorodehydrocorticosterone

FLUORCORTOLONE

flucortolone

Fluocortolon

Fluorocortolone

SH 742

SH-742

(6S,8S,9S,10R,11S,13S,14S,16R,17S)-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one

(6S,8S,9S,10R,11S,13S,14S,16R,17S)-6-fluoro-11-hydroxy-17-(2-hydroxyethanoyl)-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one

(6S,8S,9S,10R,11S,13S,14S,16R,17S)-6-fluoro-17-glycoloyl-11-hydroxy-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one

(6α,11β,16α)-6-Fluoro-11,21-dihydroxy-16-Methylpregna-1,4-diene-3,20-dione

16α-Methyl-6α-fluoro-1,4-pregnadien-11β,21-diol-3,20-dione

17alpha-propyl-5alpha-androstan-3-one

FLUOCORTOLONE

Fluocortolone (Fluocortolone Pivalate EPImpurity A)

Fluocortolone Pivalate EP Impurity A

Pregna-1,4-diene-3,20-dione, 6-fluoro-11,21-dihydroxy-16-methyl-, (6α,11β,16α)-

Fluocortolone USP/EP/BP

Fluocortolone Impurity 13

Fluocortolone Pivalate EP Impurity A (Fluocortolone)

Fluocortolone Pivalate Impurity 1 (Fluocortolone Pivalate EP Impurity A)(Fluocortolone)

152-97-6

C22H29FO4

Intermediates & Fine Chemicals

Pharmaceuticals

Steroids