Boc-D-Asparagine

Product Name: Boc-D-Asparagine
CAS No.: 75647-01-7
Chemical Name: Boc-D-Asparagine
Synonyms: Nalpha D;BOC-D-ASN;BOC-D-ASN-OH;Z-D-Leu.DCHA;N-BOC-D-Asn-OH;BOC-D-ASPARAGINE;Nα-Boc-D-asparag;N-BOC-D-ASPARAGINE;Nalpha-BOC-D-Asn-OH;Nα-Boc-D-asparagine
CBNumber: CB3408755
Molecular Formula: C9H16N2O5
Formula Weight: 232.23
MOL File: 75647-01-7.mol

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Boc-D-Asparagine Property

Melting point:: 165-169 °C
alpha: 9 º (c=1, DMF)
Boiling point:: 374.39°C (rough estimate)
Density: 1.2896 (rough estimate)
refractive index: 7.7 ° (C=1, DMF)
storage temp.: Sealed in dry,2-8°C
solubility: soluble in Dimethylformamide
pka: 3.79±0.10(Predicted)
form: Powder
color: White
BRN: 4843040
CAS DataBase Reference: 75647-01-7(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 24/25-45
WGK Germany: 3
HS Code: 29241990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53088
Product name: Boc-D-Asn-OH
Purity: Novabiochem?
Packaging: 25g
Price: $1420
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15064
Product name: Boc-D-Asn-OH
Purity: ≥98.0% (TLC)
Packaging: 5g
Price: $210
Updated: 2025/07/31

TCI Chemical

Product number: B2964
Product name: Nalpha-(tert-Butoxycarbonyl)-D-asparagine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $26
Updated: 2025/07/31

TCI Chemical

Product number: B2964
Product name: Nalpha-(tert-Butoxycarbonyl)-D-asparagine
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $65
Updated: 2025/07/31

TRC

Product number: B622000
Product name: Nα-Boc-D-asparagine
Packaging: 5g
Price: $120
Updated: 2021/12/16

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Boc-D-Asparagine Chemical Properties,Usage,Production

Chemical Properties

white fine crystalline powder

Uses

Nα-Boc-D-asparagine is an N-Boc-protected form of D-Asparagine (A788990). D-Asparagine is an isomer of L-Asparagine (A790005) and is used by bacteria (such as Saccharomyces cerevisiae) as a sole nitrogen source for replication. L-Asparagine is also a competitive inhibitor of staphylococcal L-asparaginase and is used as a reagent to synthesize peptide antibiotics.

Definition

ChEBI: Boc-D-asparagine is an asparagine derivative.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

2058-58-4

24424-99-5

7536-55-2

General procedure for the synthesis of BOC-L-asparagine from D-asparagine monohydrate and di-tert-butyl dicarbonate: in Example 75, 5-[5-fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidene-methylene]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid [(S)-1-(2-methoxy-ethyl)-2,5-dioxo-pyrrolidin- 3-yl]-amide ester (75a, 2.0 g, 15 mmol) and Na2CO3 (1.6 g, 15 mmol) were dissolved in a solvent mixture of H2O/1,4-dioxane (30 mL/30 mL). To this solution, di-tert-butyl dicarbonate (Boc)2O (3.96 g, 18.2 mmol) was added dropwise at room temperature. The reaction mixture was stirred overnight and subsequently 1,4-dioxane was removed by evaporation. The remaining aqueous solution was adjusted to pH=2 with 37% HCl. The precipitate precipitated was filtered, washed with water and dried to afford the target product 75b (2.97 g, 84% yield) as a white solid.

References

[1] Patent: WO2008/33562, 2008, A2. Location in patent: Page/Page column 86
[2] Patent: US2009/76005, 2009, A1. Location in patent: Page/Page column 44
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 7, p. 2936 - 2947
[4] Journal of the American Chemical Society, 2014, vol. 136, # 26, p. 9244 - 9247

Boc-D-Asparagine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Boc-D-Asparagine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Boc-D-Asparagine 75647-01-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-12

Career Henan Chemical Co

Product: Boc-D-Asparagine 75647-01-7
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-07-31

75647-01-7, Boc-D-AsparagineRelated Search:

Di-tert-butyl dicarbonate 1,1'-Carbonyldiimidazole 2-Chloro-2-methylpropane L-Asparagine ASPARAGINASE D-(-)-Asparagine monohydrate FMOC-ASN(TRT)-OPFP DI-TERT-BUTYL ETHER NICKEL CARBONYL BOC-L-Asparagine Carbonyl iron powder Boc-D-2,4-diaminobutyric acid D-2,4-Diaminobutyric acid N-Boc-1,3-propanediamine BOC-L-ASPARAGINE(TRITYL) BOC-ASP-OH N-BOC-L-ASPARAGINE(XANTHYL) BOC-D-ASN(TRT)-OH

NALPHA-BOC-D-ASPARAGINE

N-BOC-D-ASPARAGINE

NALPHA-(TERT-BUTOXYCARBONYL)-D-ASPARAGIN

NALPHA-(TERT-BUTOXYCARBONYL)-D-ASPARAGINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-D-ASPARAGINE

N-ALPHA-T-BUTYLOXYCARBONYL-D-ASPARAGINE

N-ALPHA-T-BUTOXYCARBONYL-D-ASPARAGINE

N-ALPHA-T-BOC-D-ASPARAGINE

T-BUTYLOXYCARBONYL-D-ASPARAGINE

BOC-D-ASPARAGINE

BOC-D-ASN-OH

BOC-D-ASN

N-BOC-D-Asn-OH

NA-T-BOC-D-ASPARAGINE

N-(tert-Butoxycarbonyl)-D-asparagine

N2-[(1,1-DIMETHYLETHOXY)CARBONYL]-D-ASPARAGINE

BOC-D-ASPARGINE extrapure

Nalpha-BOC-D-Asparagine,98%

Nalpha-Boc-D-asparagine Boc-D-Asn-OH

Nalpha-BOC-D-Asn-OH

Nα-tert-Butyloxycarbonyl-D-asparagine ,98%

Nalpha-BOC-D-Asparag

(R)-4-aMino-2-((tert-butoxycarbonyl)aMino)-4-oxobutanoic acid

N^a-Boc-D-asparagine, 95%

Z-D-Leu.DCHA

Boc-D-aspaD23-Ragine

Boc-(R)-2-aminosuccinic acid 4-amide monohydrate

Nα-Boc-D-asparagine≥ 99% (HPLC)

(Tert-Butoxy)Carbonyl D-Asn-OH

(2R)-2-{[(tert-butoxy)carbonyl]amino}-3-carbamoylpropanoic acid

Nα-(tert-Butoxycarbonyl)-D-asparagine &gt

Nalpha D

Nα-Boc-D-asparag

D-Asparagine, N2-[(1,1-dimethylethoxy)carbonyl]-

Nα-Boc-D-asparagine

(2R)-4-amino-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxobutanoicaci

Boc-D-Asparagine USP/EP/BP

Nα-(tert-Butoxycarbonyl)-D-asparagine

(R)-4-Amino-2-((tert-butoxycarbonyl)amino)-4-oxobutanoic acid - [A91136]

75647-01-7

C9H15N2O5

Amino Acid Derivatives

Asparagine

Peptide Synthesis

Specialty Synthesis

Asparagine [Asn, N]

Amino Acids (N-Protected)

Biochemistry

Boc-Amino Acids

Amino Acids

Amino Acid Derivatives