ChemicalBook > CAS DataBase List > Formamidine acetate

Formamidine acetate

Product Name
Formamidine acetate
CAS No.
3473-63-0
Chemical Name
Formamidine acetate
Synonyms
FAA;forMiMidaMide acetate;Formamidinium acetate;FORMAMIDINE ACETATE SALT;IMINOFORMAMIDE ACETATE;Methanimidamide(9CI);Methanimidamide monoacetate;FORMAMIDINE ACETIC ACID SALT;CB3408896;ormamidine acetate
CBNumber
CB3408896
Molecular Formula
C3H8N2O2
Formula Weight
104.11
MOL File
3473-63-0.mol
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Formamidine acetate Property

Melting point:
158-161 °C (dec.)(lit.)
Density 
1.124
storage temp. 
Store below +30°C.
solubility 
832g/l
form 
Liquid
color 
Clear colorless to light yellow
PH
8 (400g/l, H2O, 20℃)
Water Solubility 
832 g/L (21 ºC)
Sensitive 
Hygroscopic
BRN 
3563488
InChI
InChI=1S/C2H4O2.CH4N2/c1-2(3)4;2-1-3/h1H3,(H,3,4);1H,(H3,2,3)
InChIKey
XPOLVIIHTDKJRY-UHFFFAOYSA-N
SMILES
C(C)(=O)O.C(=N)N
CAS DataBase Reference
3473-63-0(CAS DataBase Reference)
EPA Substance Registry System
Methanimidamide, monoacetate (3473-63-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
43-36/37/38
Safety Statements 
36/37-37/39-26-36/37/39-27
WGK Germany 
2
F 
3-9-21
Autoignition Temperature
565 °C
TSCA 
Yes
HS Code 
29252000
Toxicity
LD50 orally in Rabbit: 2510 mg/kg LD50 dermal Rat > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F15803
Product name
Formamidine acetate salt
Purity
99%
Packaging
100g
Price
$61.7
Updated
2024/03/01
Sigma-Aldrich
Product number
F15803
Product name
Formamidine acetate salt
Purity
99%
Packaging
500g
Price
$229
Updated
2024/03/01
Sigma-Aldrich
Product number
8.14653
Product name
Formamidine acetate
Purity
for synthesis
Packaging
100g
Price
$123
Updated
2024/03/01
Sigma-Aldrich
Product number
8.14653
Product name
Formamidine acetate
Purity
for synthesis
Packaging
500g
Price
$333
Updated
2024/03/01
TCI Chemical
Product number
F0154
Product name
Formamidine Acetate
Purity
>98.0%(T)
Packaging
25g
Price
$22
Updated
2024/03/01
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Formamidine acetate Chemical Properties,Usage,Production

Description

Formamidine acetate is an anti-tuberculosis drug that belongs to the class of aminoglycosides. It has been shown to have a potent cytotoxic effect on malignant brain cells in vitro. It inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. It also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.

Chemical Properties

white to light yellow crystalline powder

Uses

Formamidine acetate is used as an intermediate in the synthesis of active pharmaceutical ingredients. It is also used as a condensing agent for the preparation of pyrimidine and imidazole heterocycles.

Uses

Formamidine acetate salt is widely used in the preparation of formamidinium lead triiodide (FAPbI3) perovskites for perovskite solar cells. It is also used in the synthesis of formamidinium lead bromide nanocrystals for use as emitters in display applications.

Purification Methods

Unlike the hydrochloride, the acetate salt is not hygroscopic. It is recrystallised from a small volume of acetic acid, by addition of EtOH and the crystals are washed with EtOH then Et2O and dried in a vacuum. [Taylor et al. Org Synth 46 39 1966, Beilstein 2 IV 82.]

Formamidine acetate Preparation Products And Raw materials

Raw materials

Preparation Products

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine 5-METHOXY-QUINAZOLIN-4-YLAMINE 4-HYDROXY-5-NITROPYRIMIDINE 4,6-DIHYDROXY-5-METHYLPYRIMIDINE 4-Hydroxy-6-(trifluoromethyl)pyrimidine 4-chloro-5-fluoropyrimidine 4-Hydroxy-5-fluorpyrimidine 4-AMINOPYRIMIDINE-5-CARBONITRILE 6-CHLOROQUINAZOLIN-4-AMINE 4,6-Dimethylpyrimidine-5-carboxylic acid 4-Amino-6-methylpyrimidine-5-carbonitrile ,97% 4-Imidazolemethanol hydrochloride 4-AMINOPYRIMIDINE-5-CARBOXAMIDE
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View Lastest Price from Formamidine acetate manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
Formamidine acetate 3473-63-0
Price
US $100.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
1000
Release date
2024-05-17
Shanghai UCHEM Inc.
Product
Formamidine acetate 3473-63-0
Price
US $45.00-230.00/g
Min. Order
25g
Purity
0.98
Supply Ability
100kg
Release date
2023-10-25
Hebei Weibang Biotechnology Co., Ltd
Product
Formamidine acetate 3473-63-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-31

3473-63-0, Formamidine acetateRelated Search:

Vinyl acetate FORMAMIDINE HYDROCHLORIDE Amitraz Methyl acetate Ethyl acetate N-2,4-DIMETHYLPHENYL-N'-METHYLFORMAMIDINE Medroxyprogesterone Acetate Butyl acetate Sodium acetate Tocopheryl acetate Glatiramer acetate BENZAMIDINE Methoxyacetic acid POLY(VINYL ACETATE) Linalyl acetate Cinnamyl acetate N-DECYL ACETATE N-ALPHA-BENZOYL-L-ARGININE

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  • HNCHNH2CH3COOH
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