ChemicalBook > CAS DataBase List > 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole

5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole

Product Name
5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole
CAS No.
124750-53-4
Chemical Name
5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole
Synonyms
TTMB;5-(4;ENTERPRISESTANDARD;Losartan Impurity 9;Olmesartan TTMB impurity;5-[2-(4-methylphenyl)phenyl]-1-trityltetrazole;5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole;5-(4'-Methyl-2-biphenylyl)-1-trityl-1H-tetrazole;Olmesartan Medoxomil Impurity 24（Losartan Impurity 9）;N-(TRIPHENYLMETHYL)-5-(4'-METHYLBIPHENYL-2-YL)TETRAZOLE
CBNumber
CB3438158
Molecular Formula
C33H26N4
Formula Weight
478.59
MOL File
124750-53-4.mol
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5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole Property

Melting point:
166-169 °C(Solv: ethyl acetate (141-78-6); dichloromethane (75-09-2))
Boiling point:
681.6±65.0 °C(Predicted)
Density 
1.13±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Slightly)
form 
Solid
pka
0.30±0.10(Predicted)
color 
Off-White
InChI
InChI=1S/C33H26N4/c1-25-21-23-26(24-22-25)30-19-11-12-20-31(30)32-34-35-36-37(32)33(27-13-5-2-6-14-27,28-15-7-3-8-16-28)29-17-9-4-10-18-29/h2-24H,1H3
InChIKey
ZSBYTGRKIKIRRJ-UHFFFAOYSA-N
SMILES
N1(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C(C2=CC=CC=C2C2=CC=C(C)C=C2)=NN=N1
CAS DataBase Reference
124750-53-4(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

TRC
Product number
T889172
Product name
N-Triphenylmethyl-5-[4''-methylbiphenyl-2-yl]tetrazole-d4
Packaging
10mg
Price
$165
Updated
2021/12/16
Matrix Scientific
Product number
093682
Product name
5-(4'-Methyl-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole
Purity
95+%
Packaging
250mg
Price
$341
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
D62492
Product name
N-Triphenylmethyl-5-[4??-methylbiphenyl-2-yl]tetrazole-d4
Packaging
10mg
Price
$650
Updated
2021/12/16
Matrix Scientific
Product number
093682
Product name
5-(4'-Methyl-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole
Purity
95+%
Packaging
1g
Price
$756
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
APN0000403
Product name
5-(4'-METHYLBIPHENYL-2-YL)-1-TRITYL-1H-TETRAZOLE
Purity
95.00%
Packaging
1G
Price
$780.15
Updated
2021/12/16
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5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole Chemical Properties,Usage,Production

Chemical Properties

Off-white Solid

Uses

An intermediate in the preparation of labelled Candesartan.

Uses

5-?(4''-?Methyl-?[1,?1''-?biphenyl]?-?2-?yl)?-?1-?trityl-?1H-?tetrazole is a reactant in the synthesis of anti-microbial agents.

Synthesis

5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole is prepared by the reaction of trityl chloride and 2-(tetrazol-5-yl)-4'-methyl-1,1'-biphenyl. The specific synthesis steps are as follows:
Dissolve compound 2 (200 g) with stirring at 40°C 700mL of acetone, Aqueous sodium hydroxide solution (40.67 g sodium hydroxide dissolved in 160 mL water) is added, Continue stirring for 1h, A solution of triphenylchloromethane in acetone (270.8 g of triphenylmethyl chloride dissolved in 800 mL of acetone) was initially added dropwise. The solid was added dropwise and gradually evolved into a white turbid liquid. The reaction was monitored by TLC until it was completely filtered off and washed with water to give a solid as intermediate 3. The solid was blow dried at 50°C to give white intermediate 3 (385 g), yield: 95.2%, HPLC: 99.44%.

References

[1] Patent: WO2013/78237, 2013, A1. Location in patent: Page/Page column 111; 112
[2] Patent: CN107935957, 2018, A. Location in patent: Paragraph 0020; 0040-0042
[3] Synthetic Communications, 2008, vol. 38, # 20, p. 3577 - 3581
[4] Journal of Chemical Sciences, 2011, vol. 123, # 4, p. 393 - 401
[5] Archiv der Pharmazie, 2016, vol. 349, # 12, p. 934 - 943

5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole Suppliers

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View Lastest Price from 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole 124750-53-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-20
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Olmesartan Medoxomil Impurity 19 124750-53-4
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-06-14
Shaanxi Dideu Medichem Co. Ltd
Product
5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole 124750-53-4
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-09

124750-53-4, 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazoleRelated Search:

Triphenylmethyl Chloride Trityl candesartan Trityl Irbesartan Trityl candesartan cilexetil 4,4'-Dimethylbiphenyl 2,3,5-Triphenyltetrazolium chloride Silicone oil (high temperature) Chlorodimethylphenylsilane Trityl olmesartan 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole 2-Butyl-4-chloro-5-hydroxymethyl-1-[[2'-(1H-2-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole 4-Phenyltoluene methylphenyl silicone resin Benzyl N-[(2(Trityltetrazol-5-yl-1,1biphenyl-4-yl]-methyl-2-amino-3-methylbutanoate 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole AKOS 91708 AKOS 91707

  • 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole
  • 5-[4'-METHYL (1,1'-BIPHENYL)-2-YL]-1-TRIPHENYLMETHYL-TETRAZOLE
  • 5-[2-(4-methylphenyl)phenyl]-1-trityltetrazole
  • N-(Triphenylmethyl)-5-(4'-Methylbiphenyl-2-Yl-)Tetrazole (Ttmb)
  • Olmesartan TTMB impurity
  • 1-[2-(diphenylmethyl)phenyl]-5-[2-(4-methylphenyl)phenyl]tetrazole
  • Losartan Impurity 9
  • n-(triphenylmethyl)-5-(4'-methylbiphenyl-2-yl-)terazole
  • N-(TRIPHENYLMETHYL)-5-(4'-METHYLBIPHENYL-2-YL)TETRAZOLE
  • 5-(4'-Methyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole
  • 5-[4''-METHYL (1,1''-BIPHENYL)-2-YL]-1-TRIPHENYLMETHYL-TETRAZOLE 98.5+%
  • N-TriphenylMethyl-5-[4'-Methylbiphenyl-2-yl]tetrazole-d4
  • 5-(4'-Methyl-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole
  • ENTERPRISESTANDARD
  • 5-(5-Methyl-2-phenylphenyl)-1-(triphenylMethyl)-1H-1,2,3,4-tetrazole
  • Losartan IMpurity (5-(4'-Methylbiphenyl-2-yl)-1-Trityl-1H-Tetrazole)
  • TTMB
  • Olmesartan Medoxomil impurity 8/Olmesartan TTMB Impurity/5-(4'-Methyl-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole
  • 1H-Tetrazole, 5-(4'-methyl[1,1'-biphenyl]-2-yl)-1-(triphenylmethyl)-
  • Losartan Impurity （5-?(4’-?Methyl-?[1,?1’-?biphenyl]?-?2-?yl)?-?1-?trityl-?1H-?tetrazole）
  • 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole USP/EP/BP
  • 5-?(4'-?Methyl-?[1,?1'-?biphenyl]?-?2-?yl)?-?1-?trityl-?1H-?tetrazole DISCONTINUED. Please see T889170
  • Olmesartan Medoxomil Impurity 24（Losartan Impurity 9）
  • 5-(4'-Methyl[1,1'-biphenyl]-2-yl)-1-(triphenylmethyl)-1H-tetrazole
  • 5-(4
  • 5-(4'-Methyl-2-biphenylyl)-1-trityl-1H-tetrazole
  • N-(Triphenylmethyl)-5-(4'-Methylbiphenyl-2-yl) Tetrazole
  • 5-(4'-METHYL-[1,1'-BIPHENYL]-2-YL)-1-TRITYL-1H- TETRAZOLE / PENULTIMATE IMPURITY
  • 5-(4'-Methyl-biphenyl-2-yl)-1-(triphenylmethyl)-1H-tetrazole
  • 124750-53-4
  • C33H22D4N4
  • C34H29N4
  • C33H26N4
  • Biphenyl & Diphenyl ether
  • API intermediates
  • Hypertension