Methoxyamine Hydrochloride Property

Melting point:

151-154 °C(lit.)

Boiling point:

105-110°C

Density 

1.1 g/mL at 25 °C

refractive index 

n20/D 1.4021

storage temp. 

Sealed in dry,Room Temperature

solubility 

alcohol: soluble(lit.)

form 

Crystalline Powder

color 

White to very faint yellow

Water Solubility 

SOLUBLE

Sensitive 

Hygroscopic

Merck 

14,5989

BRN 

3589723

InChIKey

XNXVOSBNFZWHBV-UHFFFAOYSA-N

CAS DataBase Reference

593-56-6(CAS DataBase Reference)

EPA Substance Registry System

O-Methylhydroxylamine hydrochloride (593-56-6)

Safety

Hazard Codes 

C,Xi,N

Risk Statements 

34-36/37/38-50-43-20/21/22-37-35

Safety Statements 

3-24-26-36/37/39-45-61-24/25-27

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

RTECS 

NC3980000

F 

3-10

Hazard Note 

Corrosive/Hygroscopic

TSCA 

Yes

HS Code 

2928 00 90

HazardClass 

8

PackingGroup 

III

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Methoxyamine Hydrochloride Chemical Properties,Usage,Production

Methoxyamine hydrochloride

Methoxyamine hydrochloride (also known as O-methylhydroxylamine hydrochloride; Methoxyamine; Methoxyamine hydrochloride (OMHA), is an important medicine, pesticide intermediates. Its major applications are as follows:

• it can be used for color photography and film printing.
• it is used as a reducing agent in organic synthesis industry for preparation of oximes.
• the field of medicine: it can be used for the synthesis of second-generation cephalosporins antibiotics cefuroxime (ester), neopropene, norethindine and hydroxyurea.
• the field of pesticides: the synthesis of new efficient, low-toxicity bactericidal metominostrobin.
• It is mainly produced by sodium nitrite method in our country.

Application

• Used as a methoxyamine reagent, also used in the production of the side chain of Cefuroxime and other new drugs
• Used for pesticide synthesis.
• Use for pharmaceuticals production
• Used for the preparation of O-methyloxime together with aldehydes or ketones.

Description

Methoxamine hydrochloride, also known as methoxamine hydrochloride, O-methyl hydroxylamine hydrochloride. It is a white crystalline powder, and its fusing point is 149 ~ 152 DEG C, soluble in water, dissolved in alcohol, insoluble in ether and toluene, etc., and the solution is in acid. Methoxamine hydrochloride is an important chemical and medicine intermediate, can be used for the development and printing of color photography and film, and is widely used in the synthesis of medicine, functional dye, low-toxin farm chemicals, and new herbicides. Methoxamine hydrochloride is mainly used in the synthesis of s-generation cephalosporin product cephalofruxin in medical, and sulfamethoxazole; alkynes promise are bright, the synthesis of hydroxyurea, etc.; Agricultural chemicals aspect is then mainly used in the kresoxim-methyl of synthesizing efficient low toxicity.

Chemical Properties

White to very faintly yellow crystalline powder

Uses

antineoplastic, hydroxymethyltransferase inhibitor

Uses

Methoxylamine is a methoxime derivative used as internal standard for Prostaglandin assays by gas chromatography-mass spectrometry

Uses

Methoxylamine hydrochloride is used as a reagent in the preparation of O-methyl oximes from aldehydes. It is orally bioavailable small molecule inhibitor with potential adjuvant activity. It is also used as internal standard for prostaglandin assays by gas chromatography-mass spectrometry.

General Description

Off-white crystals.

Air & Water Reactions

Water soluble.

Reactivity Profile

In aqueous solution, Methoxyammonium chloride behaves as an acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.

Fire Hazard

Flash point data for Methoxyammonium chloride are not available. Methoxyammonium chloride is probably combustible.

Purification Methods

Crystallise the hydrochloride from absolute EtOH or EtOH by addition of diethyl ether. [Kovach et al. J Am Chem Soc 107 7360 1985, Beilstein 1 IV 1252.]