Methoxyamine hydrochloride Application
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Methoxyamine Hydrochloride

Methoxyamine hydrochloride Application
Product Name
Methoxyamine Hydrochloride
CAS No.
593-56-6
Chemical Name
Methoxyamine Hydrochloride
Synonyms
METHOXYAMINE HYDROCHLORIDE;O-METHYLHYDROXYLAMINE HYDROCHLORIDE;MAH;METHOXYLAMINE HYDROCHLORIDE;METHYLHYDROXYLAMINE HYDROCHLORIDE;O-METHOXYAMINE HCL;O-METHYLHYDROXYLAMINE HCL;METHOXYAMINE HCL;O-METHYLHYDROXYLAMMONIUM CHLORIDE;O-METHYLHYDROXYAMINE HYDROCHLORIDE
CBNumber
CB3439014
Molecular Formula
CH5NO.ClH
Formula Weight
83.52
MOL File
593-56-6.mol
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Methoxyamine Hydrochloride Property

Melting point:
151-154 °C(lit.)
Boiling point:
105-110°C
Density 
1.1 g/mL at 25 °C
refractive index 
n20/D 1.4021
storage temp. 
Sealed in dry,Room Temperature
solubility 
alcohol: soluble(lit.)
form 
Crystalline Powder
color 
White to very faint yellow
Water Solubility 
SOLUBLE
Sensitive 
Hygroscopic
Merck 
14,5989
BRN 
3589723
InChIKey
XNXVOSBNFZWHBV-UHFFFAOYSA-N
CAS DataBase Reference
593-56-6(CAS DataBase Reference)
EPA Substance Registry System
O-Methylhydroxylamine hydrochloride (593-56-6)
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Safety

Hazard Codes 
C,Xi,N
Risk Statements 
34-36/37/38-50-43-20/21/22-37-35
Safety Statements 
3-24-26-36/37/39-45-61-24/25-27
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
RTECS 
NC3980000
F 
3-10
Hazard Note 
Corrosive/Hygroscopic
TSCA 
Yes
HS Code 
2928 00 90
HazardClass 
8
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
89803
Product name
Methoxyamine hydrochloride
Purity
for GC derivatization, LiChropur?, 97.5-102.5% (AT)
Packaging
1G
Price
$50.2
Updated
2025/07/31
Sigma-Aldrich
Product number
89803
Product name
Methoxyamine hydrochloride
Purity
for GC derivatization, LiChropur?, 97.5-102.5% (AT)
Packaging
5G
Price
$169
Updated
2025/07/31
Sigma-Aldrich
Product number
225517
Product name
Methoxylamine hydrochloride solution
Purity
25-30 wt. % in H2O
Packaging
25g
Price
$71.4
Updated
2023/06/20
Sigma-Aldrich
Product number
225517
Product name
Methoxylamine hydrochloride solution
Purity
25-30 wt. % in H2O
Packaging
100g
Price
$150
Updated
2023/06/20
TCI Chemical
Product number
M0343
Product name
O-Methylhydroxylamine Hydrochloride
Purity
>97.0%(N)(T)
Packaging
25g
Price
$48
Updated
2025/07/31
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Methoxyamine Hydrochloride Chemical Properties,Usage,Production

Methoxyamine hydrochloride

Methoxyamine hydrochloride (also known as O-methylhydroxylamine hydrochloride; Methoxyamine; Methoxyamine hydrochloride (OMHA), is an important medicine, pesticide intermediates. Its major applications are as follows:

  • it can be used for color photography and film printing.
  • it is used as a reducing agent in organic synthesis industry for preparation of oximes.
  • the field of medicine: it can be used for the synthesis of second-generation cephalosporins antibiotics cefuroxime (ester), neopropene, norethindine and hydroxyurea.
  • the field of pesticides: the synthesis of new efficient, low-toxicity bactericidal metominostrobin.
  • It is mainly produced by sodium nitrite method in our country.
The similar compound of methoxyamine hydrochloride, the ethoxylamine hydrochloride is mainly used for the production of herbicides, oxycarbazone, diltiazem and other herbicides.

Application

  • Used as a methoxyamine reagent, also used in the production of the side chain of Cefuroxime and other new drugs
  • Used for pesticide synthesis.
  • Use for pharmaceuticals production
  • Used for the preparation of O-methyloxime together with aldehydes or ketones.

Description

Methoxamine hydrochloride, also known as methoxamine hydrochloride, O-methyl hydroxylamine hydrochloride. It is a white crystalline powder, and its fusing point is 149 ~ 152°C, soluble in water, dissolved in alcohol, insoluble in ether and toluene, etc., and the solution is in acid. Methoxamine hydrochloride is an important chemical and medicine intermediate, can be used for the development and printing of color photography and film, and is widely used in the synthesis of medicine, functional dye, low-toxin farm chemicals, and new herbicides. Methoxamine hydrochloride is mainly used in the synthesis of s-generation cephalosporin product cephalofruxin in medical, and sulfamethoxazole; alkynes promise are bright, the synthesis of hydroxyurea, etc.; Agricultural chemicals aspect is then mainly used in the kresoxim-methyl of synthesizing efficient low toxicity.

Chemical Properties

White to very faintly yellow crystalline powder

Uses

antineoplastic, hydroxymethyltransferase inhibitor

Uses

Methoxylamine is a methoxime derivative used as internal standard for Prostaglandin assays by gas chromatography-mass spectrometry

Uses

Methoxylamine hydrochloride is used as a reagent in the preparation of O-methyl oximes from aldehydes. It is orally bioavailable small molecule inhibitor with potential adjuvant activity. It is also used as internal standard for prostaglandin assays by gas chromatography-mass spectrometry.

General Description

Off-white crystals.

Air & Water Reactions

Water soluble.

Reactivity Profile

In aqueous solution, Methoxyammonium chloride behaves as an acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.

Fire Hazard

Flash point data for Methoxyammonium chloride are not available. Methoxyammonium chloride is probably combustible.

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

Synthesis

1914-20-1

593-56-6

General procedure: 500 mg of hydroxyphthalimide (Aldrich) was dissolved in 5 mL of dimethylformamide (DMF) under argon protection, followed by the addition of 0.2 mL of methylene iodide (Aldrich) and 0.5 mL of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU, Aldrich) sequentially, slowly dropwise. The reaction mixture was stirred at 60 °C for 2 h and then cooled to room temperature and the reaction was quenched by addition of 2 N hydrochloric acid solution. The reaction solution was diluted with 20 mL of ethyl acetate, dried over magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography using ethyl acetate/hexane (1:5, v/v) as eluent and dried to give 407 mg of the target compound (yield: 75%). The compound was dissolved in 5 mL of dichloromethane and 0.11 mL of methylhydrazine (TCI) was slowly added at 0 °C. The reaction solution was stirred at room temperature for 2 hours and then cooled to 0°C again. The resulting solid was collected by filtration and 1 mL of 4 M dioxane hydrochloride solution (Aldrich) was added to the filtrate, filtered and dried to give 173 mg of solid product (yield: 90%). Under argon protection, 10 mg of the above solid was dissolved with 54 mg of SAC-0906 in 1 mL of pyridine (Aldrich) and stirred at 80 °C for 4 hours. After the reaction solution was cooled to room temperature, it was acidified by adding 2 N hydrochloric acid solution, extracted with 20 mL of ether, dried over magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography using ethyl acetate/hexane (1:5, v/v) as eluent to give the final methoxyamine hydrochloride SAC-1012 (48 mg, yield: 85%).1H-NMR (300 MHz, CDCl3) δ 5.91-5.76 (m, 2H), 5.34-5.32 (m, 1H) , 5.28-5.24 (m, 1H), 5.15 (m, 1H), 4.24-4.07 (m, 3H), 3.80 (s, 3H), 3.58-3.48 (m, 1H), 2.42-0.60 (m, 35H).

Purification Methods

Crystallise the hydrochloride from absolute EtOH or EtOH by addition of diethyl ether. [Kovach et al. J Am Chem Soc 107 7360 1985, Beilstein 1 IV 1252.]

References

[1] Patent: US2014/378399, 2014, A1. Location in patent: Paragraph 0096
[2] Journal of the Chemical Society. Perkin Transactions 2, 2000, # 7, p. 1435 - 1446
[3] European Journal of Medicinal Chemistry, 2014, vol. 75, p. 184 - 194

Methoxyamine Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

4-NITRO-PYRIDIN-3-YLAMINE PYRIDINE-2,3,6-TRIAMINE
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View Lastest Price from Methoxyamine Hydrochloride manufacturers

Xi’an Goldenfeather & One Technology Co., Ltd.
Product
O-Methylhydroxylamine hydrochloride 593-56-6
Price
US $0.00-0.00/ton
Min. Order
1ton
Purity
98%
Supply Ability
100
Release date
2025-06-10
Hebei Chuanghai Biotechnology Co., Ltd
Product
Methoxyammonium chloride 593-56-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-28
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Methoxyammonium chloride 593-56-6
Price
US $35.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-05-29

593-56-6, Methoxyamine HydrochlorideRelated Search:

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