6-(Trifluoromethyl)nicotinic acid
- Product Name
- 6-(Trifluoromethyl)nicotinic acid
- CAS No.
- 231291-22-8
- Chemical Name
- 6-(Trifluoromethyl)nicotinic acid
- Synonyms
- 3,5-Dichloropyrazine-2-carboxylic acid;6-(Trifluoromethyl)-3-pyridinecarboxylic acid;6-(TrifL;6-Trifluoromethyl;RARECHEM AL BO 1001;6-(TRIFLUOROMETHYL)PYRIDI;6-Trifluoromethylnicotic acid;TRIFLUOROMETHYL NICOTINIC ACID;6-(TRIFLUROMETHYL)NICOTINICACID;6- threefluorine Methylnicotinate
- CBNumber
- CB3440751
- Molecular Formula
- C7H4F3NO2
- Formula Weight
- 191.11
- MOL File
- 231291-22-8.mol
6-(Trifluoromethyl)nicotinic acid Property
- Melting point:
- 193-197 °C(lit.)
- Boiling point:
- 259.3±40.0 °C(Predicted)
- Density
- 1.484±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Acetonitrile (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 2.96±0.10(Predicted)
- color
- Pale Beige to Light Brown
- InChI
- InChI=1S/C7H4F3NO2/c8-7(9,10)5-2-1-4(3-11-5)6(12)13/h1-3H,(H,12,13)
- InChIKey
- JNYLMODTPLSLIF-UHFFFAOYSA-N
- SMILES
- C1=NC(C(F)(F)F)=CC=C1C(O)=O
- CAS DataBase Reference
- 231291-22-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- T2203
- Product name
- 6-(Trifluoromethyl)nicotinic Acid
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $34
- Updated
- 2025/07/31
- Product number
- T2203
- Product name
- 6-(Trifluoromethyl)nicotinic Acid
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $135
- Updated
- 2025/07/31
- Product number
- T790650
- Product name
- 6-(Trifluoromethyl)nicotinic Acid
- Packaging
- 25g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- T790650
- Product name
- 6-(Trifluoromethyl)nicotinic Acid
- Packaging
- 10g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 005417
- Product name
- 6-(Trifluoromethyl)nicotinic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $34
- Updated
- 2021/12/16
6-(Trifluoromethyl)nicotinic acid Chemical Properties,Usage,Production
Physical properties
6-Trifluoromethylnicotinic acid is a white powder with a melting point of 193-197 °C. It has a boiling point of 259.3℃ at 760 mmHg. Its density is 1.484 g/cm3. Its flash point, refractive index and vapor pressure are 110.6℃, 1.475 and 0.007mmHg at 25°C, respectively.
Uses
6-Trifluoromethyl Nicotinic Acid can be prepared to use Raf inhibitors to treat cancer.
Synthesis
216431-85-5
231291-22-8
To a 10L three-necked flask were added 1420 g of water, 2440 g of sulfuric acid, and 150 mL of glacial acetic acid, and 870 g (5 mol) of 6-(trifluoromethyl)nicotinonitrile was added slowly. The mixture was heated to reflux and kept overnight. Upon completion of the reaction, the reaction mixture was cooled, ice was added and the mixture was cooled using ice brine to precipitate a white solid. After filtration, the filtrate was extracted with ethyl acetate. The organic phases were combined and washed twice with water, followed by drying the organic phase to acidity. After washing, 930 g of 6-(trifluoromethyl)-3-pyridinecarboxylic acid was obtained as a beige solid in 97.3% yield.
References
[1] Patent: CN107298677, 2017, A. Location in patent: Paragraph 0036-0038
[2] Patent: CN107337638, 2017, A. Location in patent: Paragraph 0031; 0032; 0033
[3] Patent: EP1122242, 2001, A1
[4] Patent: US6673799, 2004, B1. Location in patent: Page column 16
6-(Trifluoromethyl)nicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
6-(Trifluoromethyl)nicotinic acid Suppliers
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- Europe
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View Lastest Price from 6-(Trifluoromethyl)nicotinic acid manufacturers
- Product
- 6-(Trifluoromethyl)nicotinic acid 231291-22-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-10-24
- Product
- 6-(Trifluoromethyl)nicotinic acid 231291-22-8
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-18
- Product
- 6-(Trifluoromethyl)nicotinic acid 231291-22-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-12