ChemicalBook > CAS DataBase List > 4,4'-Dimethoxytrityl chloride

4,4'-Dimethoxytrityl chloride

Product Name: 4,4'-Dimethoxytrityl chloride
CAS No.: 40615-36-9
Chemical Name: 4,4'-Dimethoxytrityl chloride
Synonyms: DMT;DMT-CL;4,4'-(Chloro(phenyl)Methylene)bis(Methoxybenzene);4,4-DIMETHOXYTRITYL CHLORIDE;Dimethoxy Trityl Chloride;EPB49;DMTrCl;DMT-Cl)D;DMTRT-CL;NSC 89782
CBNumber: CB3442487
Molecular Formula: C21H19ClO2
Formula Weight: 338.83
MOL File: 40615-36-9.mol

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4,4'-Dimethoxytrityl chloride Property

Melting point:: 123-125 °C
Boiling point:: 455.07°C (rough estimate)
Density: 1.0887 (rough estimate)
vapor pressure: 0Pa at 20℃
refractive index: 1.5330 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Powder
color: Pink
Water Solubility: Soluble in chloroform and methanol. Partially soluble in water
Sensitive: Moisture Sensitive
BRN: 2471942
Stability:: Hygroscopic, Moisture Sensitive
InChIKey: JBWYRBLDOOOJEU-UHFFFAOYSA-N
LogP: 5.74 at 20℃
CAS DataBase Reference: 40615-36-9(CAS DataBase Reference)
NIST Chemistry Reference: Methane, chlorobis(p-methoxyphenyl)phenyl-(40615-36-9)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-34
Safety Statements: 22-24/25-37/39-26-36-45-36/37/39
RIDADR: 3261
WGK Germany: 3
F: 10-21
HS Code: 29093090
Toxicity: A hallucinogenic (psychedelic) agent that may catalyze the onset of emotional problems or psychosis in predisposed individuals. DMT is perhaps one of the least studied of the hallucinogens. It causes perceptual alterations and illusions, including changes in touch, taste, and odor. The thinking process is substantially altered; there are hallucinations and loss of contact with reality. There have been no overdose deaths attributed to the direct effects of DMT. The drug is very short-acting, with a duration of effect of about half an hour or less.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H335May cause respiratory irritation

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 100013
Product name: 4,4′-Dimethoxytrityl chloride
Purity: 95%
Packaging: 5g
Price: $63.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 100013
Product name: 4,4′-Dimethoxytrityl chloride
Purity: 95%
Packaging: 25g
Price: $178
Updated: 2025/07/31

TCI Chemical

Product number: D1612
Product name: 4,4'-Dimethoxytrityl Chloride [Hydroxyl Protecting Agent]
Purity: >97.0%(HPLC)(T)
Packaging: 5g
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: D1612
Product name: 4,4'-Dimethoxytrityl Chloride [Hydroxyl Protecting Agent]
Purity: >97.0%(HPLC)(T)
Packaging: 25g
Price: $122
Updated: 2025/07/31

Sigma-Aldrich

Product number: 38827
Product name: 4,4′-Dimethoxytriphenylmethyl chloride
Purity: ≥97.0% (HPLC)
Packaging: 10g
Price: $118
Updated: 2025/07/31

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4,4'-Dimethoxytrityl chloride Chemical Properties,Usage,Production

Chemical Properties

4,4'-Dimethoxytrityl chloride is pink powder

Uses

4,4'-Dimethoxytrityl chloride is a versatile protecting group for primary alcohols, specially useful in oligonucleotide synthesis

Uses

4,4'-Dimethoxytrityl chloride is used as a protective reagent for oligonucleotide synthesis. It is used for selective protection and deprotection procedures for thiol and hydroxy groups in nucleoside derivatives.

Uses

Hydroxyl protecting group for nucleosides and nucleotides.

Flammability and Explosibility

Not classified

Synthesis

100-66-3

98-07-7

40615-36-9

a. In a 500 L reactor, 75 kg of trichloromethylbenzene (M = 195.48, n = 383.67 mol) and 103.72 kg of anisole (M = 108.14, n = 959.17 mol) were added, followed by the addition of 53.35 kg of the catalyst aluminum chloride (M = 133.34, n = 400.1 mol). The reaction temperature was controlled to be 30 °C and the reaction was continuously stirred for 10 h to obtain the mixed reaction solution I. b. Add 475 kg of 5% dilute hydrochloric acid to the mixed reaction solution I at 30°C and transfer to a 1000 L reactor for hydrolysis reaction for 3 hours. Subsequently, 200 kg of dichloromethane was added, stirred well and stratified. After separating the organic phase, the aqueous phase was extracted twice with 200kg of dichloromethane. All organic phases were combined and dried with anhydrous sodium sulfate for 2 hours. c. Concentrate the dichloromethane to recover the solvent. 70.74 kg of epichlorohydrin (M = 126.93, n = 557.32 mol) was added and the reaction was carried out under reflux for 6 hours. After completion of the reaction, 130 kg of petroleum ether was added dropwise and cooled to 30°C for crystallization. Crude 4,4'-dimethoxytrityl chloride (DMT-Cl) was obtained by solid-liquid separation, and the HPLC purity of the crude product was 98.91%. d. The crude DMT-Cl was recrystallized with 4.5 times mass of dichloromethane and 20 times mass of petroleum ether, and the wet product was obtained by solid-liquid separation. The wet product was dried to give a final product DMT-Cl 110.66 kg with a purity of 99.95% and a yield of 85.13%. The recovered mixed solvent was quantitatively analyzed by gas chromatography (GC) and recycled.

Purification Methods

DMT crystallises from cyclohexane/acetyl chloride as the hydrochloride. Dry it over KOH pellets in a desiccator. When dissolved in *C6H6 and air is blown through, HCl is removed. It crystallises from Et2O. [Baeyer & Villiger Chem Ber 36 2788 1903, Smith et al. J Am Chem Soc 84 430 1962, Smith et al. J Am Chem Soc 85 3821 1963.] Ifit has hydrolysed considerably (see OH in IR), then repeat the crystallisation from cyclohexane/acetyl chloride — excess of AcCl is removed in a vacuum over KOH, then recrystallise it from Et2O. [Beilstein 6 IV 1042.]

References

[1] Patent: CN107056590, 2017, A. Location in patent: Paragraph 0022; 0023; 0024; 0025; 0026; 0027; 0028-0045

4,4'-Dimethoxytrityl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4,4'-Dimethoxytrityl chloride manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 4,4'-Dimethoxytrityl chloride 40615-36-9
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-27

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4,4'-Dimethoxytrityl chloride 40615-36-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-01

Henan Aochuang Chemical Co.,Ltd.

Product: 4,4'-Dimethoxytrityl chloride 40615-36-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-22

40615-36-9, 4,4'-Dimethoxytrityl chlorideRelated Search:

Calcium chloride Diphenyldiethoxysilane Zinc chloride Triphenylmethyl Chloride (Trifluoromethoxy)benzene Ammonium chloride p-Anisaldehyde Triphenylphosphine Oxalyl chloride Thionyl chloride Benzyltriphenylphosphonium chloride 4-Methoxyphenylacetone m-Anisyl alcohol 4-(Chloromethyl)benzoic acid Chloromethane Anisole Triphenylmethanethiol 4-Methoxytriphenylmethyl chloride

1,1'-(chlorophenylmethylene)bis[4-methoxybenzene]

4,4'-DIMETHOXY-TRIPHENYLCHLOROMETHANE

4,4-DIMETHOXYTRITYL CHLORIDE

DMT-Cl (4,4-Dimethoxytrityl Chloride)

4,4-Dimethoxytritylchloride98+%

Dimethoxy Trityl Chloride

Bis(4-methoxyphenyl)phenylmethyl chloride

Chlorobis(4-methoxyphenyl)phenylmethane

4,4'-Dimethoxytrityl

4,4'-Dimethoxytrityl Chloride [Hydroxyl Protecting Agent]

P, P'-DIMETHOXYTRIPHENYLMETHYLHLORIDE

TIMTEC-BB SBB006479

DMT-CL 4,4''-DIMETHOXYTRIPHENYLMETHYL CHLORIDE

4,4''-DIMOTHOXYTRITYLCHLORIDE

4,4'-Dimethoxytrityl chloride (DMT-Cl)

4,4''-DIMETHOXY-TRIPHENYLCHLORMETHANE

44’Dimethoxytriphenylmethyl chlide

(DMT-C1) 4,4'-DiMethoxytrityl chloride

4,4'-(Chloro(phenyl)Methylene)bis(Methoxybenzene)

DMT-Cl)D

4,4- twoMethoxy threephenylMethyl chloride

DMT-Cl, 98%, pink color

4,4'-DiMethoxytrityl chloride SynonyMs 1,1'-(ChlorophenylMethylene)bis[4-Methoxybenzene]

Anti-Dematin, C-Terminal antibody produced in rabbit

EPB49

Erythrocyte membrane protein band 4.9

4,4'-Dimethoxytriphenylmethyl chloride >=97.0% (HPLC)

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DI-P-ANISYLPHENYLMETHYL CHLORIDE

DMTRT-CL

DMT CHLORIDE

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CHLORO-4,4'-DIMETHOXYTRIPHENYLMETHANE

BENZENE, 1,1'-(CHLOROPHENYLMETHYLENE)BIS[4-METHOXY-]

1-[Chloro-(4-methoxyphenyl)-phenylmethyl]-4-methoxybenzene

4,4'-Dimethoxytrityl chloride 98%

Bis(4-methoxyphenyl)phenylchloromethane

α-Chloro-α-phenyl-α-(4-methoxyphenyl)-4-methoxytoluene

4,4’-dimethoxytritrylchloride

TRT(MEO)2-CL

4,4'-Dimethoxytrityl chloride ,99%

4,4'-Dimethoxytriphe

4'-DiMethoxytrityl chloride

4,4zzhlxy-Dimethoxytritylchloride (DMT-Cl)

1-[chloro(4-Methoxyphenyl)benzyl]-4-Methoxybenzene

4,4'-Dimethoxytriphenylmethyl chloride(DMT-CL)

4,4'-Dimethoxytrityl Chloride [Hydroxyl Protecting Agent]&gt

DMT-CL 4,4'-Dimethoxytriphenylmethyl chloride ,98%

4,4'-DimethoxytriphenyL

4,4'-Dimethoxytrityl chloride USP/EP/BP

4,4'-Dimethoxytrityl chlorider

-Dimethoxytrityl chloride

99% 44’Dimethoxytriphenylmethyl chlide 40615-36-9 CAS NO.40615-36-9

4,4'-Dimethoxytrityl chloride

4,4'-Dimethoxytrityl Chloride [Hydroxyl Protecting Agent

NSC 89782