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DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID

Product Name
DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID
CAS No.
76326-31-3
Chemical Name
DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID
Synonyms
APV;AP-5;DL-AP5;DL-APV;C13734;(±)-2-AP5;5-phosphono-L-norvaline;Norvaline, 5-phosphono-;5-PHOSPHONO-DL-NORVALINE;2-amino-5-phosphopentanoicacid
CBNumber
CB3448803
Molecular Formula
C5H12NO5P
Formula Weight
197.13
MOL File
76326-31-3.mol
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DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID Property

Melting point:
238-245oC
Boiling point:
482.1±55.0 °C(Predicted)
Density 
1.529±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
NH4OH 1 M: 50 mg/mL, clear, colorless
form 
solid
pka
2.46±0.10(Predicted)
color 
white
Water Solubility 
Soluble to 10 mM in water and to 100 mM in 1eq. NaOH
BRN 
2446389
CAS DataBase Reference
76326-31-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
10
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A5282
Product name
DL-2-Amino-5-phosphonopentanoic acid
Purity
solid
Packaging
10mg
Price
$110
Updated
2024/03/01
Sigma-Aldrich
Product number
A5282
Product name
DL-2-Amino-5-phosphonopentanoic acid
Purity
solid
Packaging
25mg
Price
$298
Updated
2024/03/01
Cayman Chemical
Product number
14540
Product name
DL-AP5
Purity
≥95%
Packaging
5mg
Price
$47
Updated
2024/03/01
Cayman Chemical
Product number
14540
Product name
DL-AP5
Purity
≥95%
Packaging
10mg
Price
$73
Updated
2024/03/01
Sigma-Aldrich
Product number
A5282
Product name
DL-2-Amino-5-phosphonopentanoic acid
Purity
solid
Packaging
50mg
Price
$477
Updated
2024/03/01
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DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID Chemical Properties,Usage,Production

Uses

DL-2-Amino-5-phosphonopentanoic acid has been used:

  • in the inactivation of N-methyl-D-aspartate (NMDA)-mediated synapses
  • used in growth medium for inhibition of electrical activity in the neuronal network
  • used to isolate N-methyl-D-aspartate receptors (NMDAR) or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated currents were isolated using this product
  • used in double distilled water to compare its NMDA antagonistic action with that of prion protein (PrPC)

Definition

ChEBI: The 5-phosphono derivative of 2-aminopentanoic acid; acts as an N-methyl-D-aspartate receptor antagonist.

Biological Activity

Potent NMDA antagonist. See separate isomers (D-(-)-2-Amino-5-phosphonopentanoic acid and L-(+)-2-Amino-5-phosphonopentanoic acid ).

Biochem/physiol Actions

Anticonvulsant; potent and selective NMDA receptor antagonist.

storage

Room temperature

DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID Suppliers

China 42 Germany 2 Japan 2 Switzerland 2 United Kingdom 8 United States 11 USA 1 Global 68
SIGMA-RBI
Tel
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Fax
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Country
Switzerland
ProdList
6896
Advantage
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Alexis Corporation
Tel
--
Fax
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Email
alexis-ch@alexis-corp.ch
Country
Switzerland
ProdList
3599
Advantage
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76326-31-3, DL-2-AMINO-5-PHOSPHONOPENTANOIC ACIDRelated Search:

2-amino-4-phosphonobutyric acid 5,7-DICHLOROKYNURENIC ACID SODIUM SALT O-Phospho-L-serine Cycloleucine Quinolinic acid Spermidine trihydrochloride (R)-CPP Synthalin sulfate L-701,252 D-AP5 L-AP5 CIS-4-[PHOSPHONOMETHYL]-PIPERIDINE-2-CARBOXYLIC ACID DL-Norvaline DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID LITHIUM SALT,DL-2-Amino-5-phosphonopentanoic acid, AP-5 5-PHOSPHONOPENTANOIC ACID DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID D(-)-2-AMINO-5-PHOSPHONO-PENTANOIC ACID, [4,5-3H]

  • APV
  • AP-5
  • DL-2-AMINO-5-PHOSPHONOVALERIC ACID
  • DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID
  • DL-AP5
  • 5-PHOSPHONO-DL-NORVALINE
  • (+/-)-2-AMINO-5-PHOSPHONO-PENTANOIC ACID
  • DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID (DL-AP5)
  • (+/-)-Amino-5-phosphono-pentanoic acid
  • DL-2-AMINO-5-PHOSPHONOVALERIC ACID (DL-AP5)
  • 5-Phosphono-DL-norvaline, DL-2-Amino-5-phosphonovaleric acid, AP-5, APV
  • (±)-2-AP5
  • DL-APV
  • rac-(2R*)-2-Amino-5-phosphonopentanoic acid
  • DL-2-Amino-5-phosphonovaleric acid (AP5)
  • C13734
  • 5-phosphono-L-norvaline
  • 2-amino-5-phosphopentanoicacid
  • Norvaline, 5-phosphono-
  • 2-amino-5-phosphonopentanoicaci
  • (S)-2-Amino-5-phosphonopentanoic acid
  • DL-AP5,2-APV,Retina,Tonic pain,Ganglion cells,Ionotropic glutamate receptors,Inhibitor,inhibit,DL-AP-5,Inhibition,DL AP5,Antinociceptive activity,iGluR,DLAP5
  • 76326-31-3
  • Ionotropic Glutamate Receptor Modulators
  • Ion Channels
  • Ligand-Gated Ion Channels
  • Substrate Analogs
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Type
  • Enzymes, Inhibitors, and Substrates
  • Cell Signaling and Neuroscience
  • Biochemicals and Reagents
  • BioChemical
  • Cell Biology
  • Glutamate
  • Glutamate receptor