ChemicalBook > CAS DataBase List > 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE

4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE

Product Name
4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE
CAS No.
33097-13-1
Chemical Name
4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE
Synonyms
2-(Methylthio)-4,6-dichloro-5-cyanopyrimidine;5-Cyano-4,6-dichloro-2-(methylthio)pyrimidine;,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE;4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE;4,6-Dichloro-2-(methylthio)-5-pyrimidinecarbonitrile;5-PyriMidinecarbonitrile, 4,6-dichloro-2-(Methylthio)-;4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBONITRILE;4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE ISO 9001：2015 REACH
CBNumber
CB3467978
Molecular Formula
C6H3Cl2N3S
Formula Weight
220.08
MOL File
33097-13-1.mol
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4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE Property

Melting point:
103-105°C
Boiling point:
367.3±37.0 °C(Predicted)
Density 
1.58±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform, Ethyl Acetate
form 
Solid
pka
-7.56±0.39(Predicted)
color 
Light Yellow
InChI
InChI=1S/C6H3Cl2N3S/c1-12-6-10-4(7)3(2-9)5(8)11-6/h1H3
InChIKey
GLOOTGZVAHKTJS-UHFFFAOYSA-N
SMILES
C1(SC)=NC(Cl)=C(C#N)C(Cl)=N1
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Safety

Hazard Codes 
T,C
Risk Statements 
25-34
Safety Statements 
26-36/37/39-45
RIDADR 
2923
WGK Germany 
3
PackingGroup 
Ⅲ
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
756091
Product name
4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile
Purity
97%
Packaging
500mg
Price
$60.4
Updated
2022/05/15
TRC
Product number
D435590
Product name
4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile
Packaging
1g
Price
$135
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD21613
Product name
4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile
Packaging
10g
Price
$400
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD21613
Product name
4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile
Packaging
5G
Price
$230
Updated
2021/12/16
Matrix Scientific
Product number
073836
Product name
4,6-Dichloro-2-(methylthio)-pyrimidine-5-carbonitrile
Purity
95+%
Packaging
5g
Price
$235
Updated
2021/12/16
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4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Solid

Uses

4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile (cas# 33097-13-1) is a compound useful in organic synthesis.

Synthesis

33097-12-0

33097-13-1

General procedure for the synthesis of 2-methylthio-4,6-dichloropyrimidine-5-oxime from 2-methylthio-4,6-dichloro-5-cyanopyrimidine: To 4,6-dichloro-2-(methylthio)-5-pyrimidine carboxaldehyde oxime (2.38 g, 10 mmol) was slowly added dichlorosulfoxide (SOCl2, 21.8 mL, 0.30 mol) at room temperature. Subsequently, the reaction mixture was heated to 75 °C with continuous stirring for about 3 hours. After completion of the reaction, the reaction solution was concentrated under vacuum. The residual dichlorosulfoxide was removed by addition of toluene (5 mL) and evaporated under vacuum. The resulting solid was washed with ethanol/water (10 mL, 1:1 v/v) to afford 4,6-dichloro-2-(methylthio)-5-pyrimidinecarbonitrile (2.04 g, 93% yield). The product was analyzed by LC-MS showing m/z 220 ([M+H]+) with a retention time of 1.99 min; 1H-NMR (CDCl3) δ 2.64 (3H, s).

References

[1] Patent: WO2006/104917, 2006, A2. Location in patent: Page/Page column 81-82
[2] Tetrahedron Letters, 2009, vol. 50, # 3, p. 370 - 372
[3] Patent: WO2006/104889, 2006, A2. Location in patent: Page/Page column 114
[4] Patent: WO2007/147109, 2007, A2. Location in patent: Page/Page column 101-102
[5] Patent: WO2007/84560, 2007, A2. Location in patent: Page/Page column 111

4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE Suppliers

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View Lastest Price from 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE manufacturers

Dideu Industries Group Limited
Product
4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE 33097-13-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-14
Career Henan Chemical Co
Product
4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE 33097-13-1
Price
US $0.01/KG
Min. Order
1KG
Purity
98%; 99%
Supply Ability
500g； 1kg; 25kg
Release date
2020-01-10
Career Henan Chemical Co
Product
4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE 33097-13-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
KG/T
Release date
2019-12-17

33097-13-1, 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILERelated Search:

4,6-Dichloro-5-iodopyrimidine 4,6-DIBROMOPYRIMIDINE 4,6-DIBROMOQUINOLINE 4,6-Dichloroquinazoline 4,6-DICHLORO-2-METHYLQUINAZOLINE 4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4,6-DICHLOROQUINOLINE 4,6-DICHLOROPYRIDO[3,4-D]PYRIMIDINE ETHYL 4,6-DICHLORO-3-QUINOLINECARBOXYLATE 4,6-Dichloro-2-(methylthio)pyrimidine 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE 2-METHYLSULFANYL-PYRIMIDINE-5-CARBONITRILE 4,6-Dichloro-5-methylpyrimidine 4-Chloro-2-(methylthio)pyrimidine-5-carbonitrile ,97% 4-Chloro-6-methyl-2-(methylthio)pyrimidine 4-CHLORO-5-METHYL-2-METHYLSULFANYL-PYRIMIDINE 5-Pyrimidinecarbonitrile, 4-chloro- (8CI,9CI) 4,6-dichloropyrimidine-5-carbonitrile

  • 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE
  • 4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBONITRILE
  • 5-Cyano-4,6-dichloro-2-(methylthio)pyrimidine
  • ,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE
  • 5-PyriMidinecarbonitrile, 4,6-dichloro-2-(Methylthio)-
  • 4,6-Dichloro-2-(methylthio)-5-pyrimidinecarbonitrile
  • 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE ISO 9001：2015 REACH
  • 2-(Methylthio)-4,6-dichloro-5-cyanopyrimidine
  • 33097-13-1
  • C6H3Cl2N3S
  • Heterocycle-Pyrimidine series
  • Heterocyclic Compounds
  • Bases & Related Reagents
  • Heterocycles
  • Nucleotides
  • Sulfur & Selenium Compounds