4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE

Product Name: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE
CAS No.: 33097-13-1
Chemical Name: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE
Synonyms: 2-(Methylthio)-4,6-dichloro-5-cyanopyrimidine;5-Cyano-4,6-dichloro-2-(methylthio)pyrimidine;,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE;4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE;4,6-Dichloro-2-(methylthio)-5-pyrimidinecarbonitrile;5-PyriMidinecarbonitrile, 4,6-dichloro-2-(Methylthio)-;4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBONITRILE;4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE ISO 9001：2015 REACH
CBNumber: CB3467978
Molecular Formula: C6H3Cl2N3S
Formula Weight: 220.08
MOL File: 33097-13-1.mol

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4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE Property

Melting point:: 103-105°C
Boiling point:: 367.3±37.0 °C(Predicted)
Density: 1.58±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform, Ethyl Acetate
form: Solid
pka: -7.56±0.39(Predicted)
color: Light Yellow
InChI: InChI=1S/C6H3Cl2N3S/c1-12-6-10-4(7)3(2-9)5(8)11-6/h1H3
InChIKey: GLOOTGZVAHKTJS-UHFFFAOYSA-N
SMILES: C1(SC)=NC(Cl)=C(C#N)C(Cl)=N1

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Safety

Hazard Codes: T,C
Risk Statements: 25-34
Safety Statements: 26-36/37/39-45
RIDADR: 2923
WGK Germany: 3
PackingGroup: Ⅲ
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 756091
Product name: 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile
Purity: 97%
Packaging: 500mg
Price: $60.4
Updated: 2022/05/15

TRC

Product number: D435590
Product name: 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile
Packaging: 1g
Price: $135
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD21613
Product name: 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile
Packaging: 1g
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD21613
Product name: 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile
Packaging: 2g
Price: $112
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H66-5-X3
Product name: 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile
Packaging: 1g
Price: $128
Updated: 2021/12/16

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4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Solid

Uses

4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile (cas# 33097-13-1) is a compound useful in organic synthesis.

Synthesis

33097-12-0

33097-13-1

General procedure for the synthesis of 2-methylthio-4,6-dichloropyrimidine-5-oxime from 2-methylthio-4,6-dichloro-5-cyanopyrimidine: To 4,6-dichloro-2-(methylthio)-5-pyrimidine carboxaldehyde oxime (2.38 g, 10 mmol) was slowly added dichlorosulfoxide (SOCl2, 21.8 mL, 0.30 mol) at room temperature. Subsequently, the reaction mixture was heated to 75 °C with continuous stirring for about 3 hours. After completion of the reaction, the reaction solution was concentrated under vacuum. The residual dichlorosulfoxide was removed by addition of toluene (5 mL) and evaporated under vacuum. The resulting solid was washed with ethanol/water (10 mL, 1:1 v/v) to afford 4,6-dichloro-2-(methylthio)-5-pyrimidinecarbonitrile (2.04 g, 93% yield). The product was analyzed by LC-MS showing m/z 220 ([M+H]+) with a retention time of 1.99 min; 1H-NMR (CDCl3) δ 2.64 (3H, s).

References

[1] Patent: WO2006/104917, 2006, A2. Location in patent: Page/Page column 81-82
[2] Tetrahedron Letters, 2009, vol. 50, # 3, p. 370 - 372
[3] Patent: WO2006/104889, 2006, A2. Location in patent: Page/Page column 114
[4] Patent: WO2007/147109, 2007, A2. Location in patent: Page/Page column 101-102
[5] Patent: WO2007/84560, 2007, A2. Location in patent: Page/Page column 111

4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE Suppliers

Canada 1 China 137 India 3 United Kingdom 2 United States 15 Global 158

A.J Chemicals

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Email: sales@ajchem.in
Country: India
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SobhaBio

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View Lastest Price from 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE manufacturers

Dideu Industries Group Limited

Product: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE 33097-13-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-14

Career Henan Chemical Co

Product: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE 33097-13-1
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g； 1kg; 25kg
Release date: 2020-01-10

Career Henan Chemical Co

Product: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE 33097-13-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: KG/T
Release date: 2019-12-17

33097-13-1, 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILERelated Search:

4,6-Dichloro-5-iodopyrimidine 4,6-DIBROMOPYRIMIDINE 4,6-DIBROMOQUINOLINE 4,6-Dichloroquinazoline 4,6-DICHLORO-2-METHYLQUINAZOLINE 4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4,6-DICHLOROQUINOLINE 4,6-DICHLOROPYRIDO[3,4-D]PYRIMIDINE ETHYL 4,6-DICHLORO-3-QUINOLINECARBOXYLATE 4,6-Dichloro-2-(methylthio)pyrimidine 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE 2-METHYLSULFANYL-PYRIMIDINE-5-CARBONITRILE 4,6-Dichloro-5-methylpyrimidine 4-Chloro-2-(methylthio)pyrimidine-5-carbonitrile ,97% 4-Chloro-6-methyl-2-(methylthio)pyrimidine 4-CHLORO-5-METHYL-2-METHYLSULFANYL-PYRIMIDINE 5-Pyrimidinecarbonitrile, 4-chloro- (8CI,9CI) 4,6-dichloropyrimidine-5-carbonitrile

4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE

4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBONITRILE

5-Cyano-4,6-dichloro-2-(methylthio)pyrimidine

,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE

5-PyriMidinecarbonitrile, 4,6-dichloro-2-(Methylthio)-

4,6-Dichloro-2-(methylthio)-5-pyrimidinecarbonitrile

4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE ISO 9001：2015 REACH

2-(Methylthio)-4,6-dichloro-5-cyanopyrimidine

33097-13-1

C6H3Cl2N3S

Heterocycle-Pyrimidine series

Heterocyclic Compounds

Bases & Related Reagents

Heterocycles

Nucleotides

Sulfur & Selenium Compounds